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Therapeutic potencial of the endocannabinoid system in multiple sclerosis: novel clues from oligodendrocyte CB1 receptors and ABHD6
(2019-03-01)
La esclerosis múltiple es una enfermedad inflamatoria crónica que afecta al sistema nervioso central y se caracteriza por el daño a los oligodendrocitos y la mielina, la infiltración de células inmunes y la degeneración ...
Contribution of Neurons and Glial Cells to Complement-Mediated Synapse Removal during Development, Aging and in Alzheimer’s Disease
(Hindawi, 2018)
Synapse loss is an early manifestation of pathology in Alzheimer's disease (AD) and is currently the best correlate to cognitive decline. Microglial cells are involved in synapse pruning during development via the complement ...
Evaluación de la capacidad antioxidante tras el debut de un trastorno mental grave.
(2019-05-08)
Existe gran evidencia de que el estrés oxidativo juega un papel fundamental en el desarrollo del trastorno mental grave. El objetivo de esta tesis doctoral es estudiar los niveles de capacidad antioxidante tras el debut ...
The MAPT H1 Haplotype Is a Risk Factor for Alzheimer’s Disease in APOE ε4 Non-carriers
(Frontiers Media, 2019-12-04)
An ancestral inversion of 900 kb on chromosome 17q21, which includes the microtubule-associated protein tau (MAPT) gene, defines two haplotype clades in Caucasians (H1 and H2). The H1 haplotype has been linked inconsistently ...
Contribution of the GABAergic System to Non-Motor Manifestations in Premotor and Early Stages of Parkinson’s Disease
(Frontiers Media, 2019-10-30)
Non-motor symptoms are common in Parkinson's disease (PD) and they represent a major source of disease burden. Several non-motor manifestations, such as rapid eye movement sleep behavior disorder, olfactory loss, ...
Functional analysis of ankrd55, a multiple sclerosis risk gene with unknown function.
(2019-01-14)
El objetivo de este trabajo consiste en la caracterización de ANKRD55, un gen de función desconocida asociado a la esclerosis múltiple (EM). Para ello, por un lado, se realizó un análisis basado en DNA y expresión génica ...
Smooth muscle cell characterization and transcriptomic analysis in human carotid atherosclerotic plaques
(2018-10-19)
Las enfermedades cardiovasculares (CV) son una de las causas más importantes de discapacidad y muerte prematura en todo el mundo. Una de las causas subyacentes de las CV es la aterosclerosis. La aterosclerosis de carótida ...
Exome sequencing in multiple sclerosis families identifies 12 candidate genes and nominates biological pathways for the genesis of disease
(Public Library Science 15(6) : (2019) // Article ID e1008180, 2019-06-06)
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system characterized by myelin loss and neuronal dysfunction. Although the majority of patients do not present familial aggregation, Mendelian forms ...
Interactome of the Autoimmune Risk Protein ANKRD55
(Frontiers Media, 2019-09-18)
The ankyrin repeat domain-55 (ANKRD55) gene contains intronic single nucleotide polymorphisms (SNPs) associated with risk to contract multiple sclerosis, rheumatoid arthritis or other autoimmune disorders. Risk alleles of ...
A 4-Trifluoromethyl Analogue of Celecoxib Inhibits Arthritis by Suppressing Innate Immune Cell Activation
(Biomed Central, 2012-01-17)
Introduction: Celecoxib, a highly specific cyclooxygenase-2 (COX-2) inhibitor has been reported to have COX-2-independent immunomodulatory effects. However, celecoxib itself has only mild suppressive effects on arthritis. ...