Search
Now showing items 171-180 of 500
Microglia: Development of a human in vitro model, analysis of motility and effects of phagocytosis in the hippocampal neurogenic niche
(2022-10-26)
This PhD Thesis discusses several topics related to microglia, the resident macrophages of the brain parenchyma. They are derived from yolk sack primitive macrophages that colonize the brain early during embryonic development. ...
Gut microbiome and serum metabolome analyses identify molecular biomarkers and altered glutamate metabolism in fibromyalgia
(Elsevier, 2019-08)
Background: Fibromyalgia is a complex, relatively unknown disease characterised by chronic, widespread musculoskeletal pain. The gut-brain axis connects the gut microbiome with the brain through the enteric nervous system ...
Risk factors associated with COVID-19 infection and mortality in nursing homes
(Elsevier, 2022-10)
Objective: The aim of this paper was to analyse the association of demographic, clinical and pharmacological risk factors with the presence of SARS-COV-2 virus infection, as well as to know the variables related to mortality ...
Impulse-control disorders in Parkinson's Disease: development of an animal model
(2020-11-12)
El objetivo de la presente tesis es el desarrollo de un modelo animal de parkinsonismo e impulsividad inducido por la administración del agonista dopaminérgico pramipexol (PPX).La enfermedad de Párkinson (EP) es una ...
Heart-brain synchronization breakdown in Parkinson's disease
(Nature, 2022-05)
Heart rate variability (HRV) abnormalities are potential early biomarkers in Parkinson's disease (PD) but their relationship with central autonomic network (CAN) activity is not fully understood. We analyzed the synchronization ...
Molecular Components and Functions of the Endocannabinoid System in Mouse Prefrontal Cortex
(Public Library of Science, 2007-08-08)
Background. Cannabinoids have deleterious effects on prefrontal cortex (PFC)-mediated functions and multiple evidences link the endogenous cannabinoid (endocannabinoid) system, cannabis use and schizophrenia, a disease in ...
Estudio clínico-epidemiológico y molecular del temblor familiar
(2017-05-25)
A pesar de la evidencia epidemiológica de la existencia de un gran porcentaje de casos familiares de TE que sugieren que la etiología del TE tiene una base genética, las variantes identificadas hasta la fecha han tenido ...
Cannabinoid CB1 receptor gene inactivation in oligodendrocyte precursors disrupts oligodendrogenesis and myelination in mice
(SpringerNature, 2022)
[EN] Cannabinoids are known to modulate oligodendrogenesis and developmental CNS myelination. However, the cell-autonomous action of these compounds on oligodendroglial cells in vivo, and the molecular mechanisms underlying ...
Demencia frontotemporal: genética, estudio evolutivo clínico, neuropsicológico y conductual
(2022-09-30)
La demencia frontotemporal (DFT) segunda forma de demencia de inicio temprano tras la enfermedad de Alzheimer (EA) representa un grupo heterogéneo de trastornos que en los últimos años está experimentando extraordinarios ...
Linking Plasma Amyloid Beta and Neurofilament Light Chain to Intracortical Myelin Content in Cognitively Normal Older Adults
(Frontiers Media, 2022-06)
Evidence suggests that lightly myelinated cortical regions are vulnerable to aging and Alzheimer's disease (AD). However, it remains unknown whether plasma markers of amyloid and neurodegeneration are related to deficits ...