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Neurocognitive, social cognitive, and clinical predictors of creativity in schizophrenia
(Pergamon-Elsevier, 2020-10)
Background: Creativity is considered an essential human accomplishment and a key component for daily life problem solving. It has been suggested that impairment in working memory, cognitive flexibility, and theory of mind ...
Mediating role of cognition and social cognition on creativity among patients with schizophrenia and healthy controls: Revisiting the Shared Vulnerability Model
(Wiley, 2019-12)
Aim As suggested by the Shared Vulnerability Model, impairment in executive functions could lead to worse creative performance among individuals with schizophrenia. Another impaired function in schizophrenia, previously ...
The impact of creativity on functional outcome in schizophrenia: a mediational model
(Springer, 2021-02-26)
Functional impairment remains one of the most challenging issues for treatment in schizophrenia. However, previous studies have mainly focused on the negative impact of symptoms excluding variables that could positively ...
Intracellular Ca2+ release through ryanodine receptors contributes to AMPA receptor-mediated mitochondrial dysfunction and ER stress in oligodendrocytes
(Nature Publishing Group, 2010-07)
Overactivation of ionotropic glutamate receptors in oligodendrocytes induces cytosolic Ca2+ overload and excitotoxic death, a process that contributes to demyelination and multiple sclerosis. Excitotoxic insults cause ...
1-42 beta-Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death
(Nature Publishing Group, 2013-01)
1-42 beta-Amyloid (A beta(1-42)) peptide is a key molecule involved in the development of Alzheimer's disease. Some of its effects are manifested at the neuronal morphological level. These morphological changes involve ...
Cannabinoid Control of Olfactory Processes: The Where Matters
(MDPI, 2020-04-16)
Olfaction has a direct influence on behavior and cognitive processes. There are different neuromodulatory systems in olfactory circuits that control the sensory information flowing through the rest of the brain. The presence ...
Histopatologian oinarritutako tratamendu kirurgikotik proteogenomikak gidatutako doitasunezko kirurgiara
(2021-06-29)
SARRERA: Urdaileko minbizia difusoaren (UMD) prebalentziak gora egin du pixkanaka, heste-motarekin berdindu arte. Arazo kliniko eta terapeutiko handiak sortzen ditu, orain arte erabilitako tratamenduei ez baitie ondo ...
Cannabinoid control of hippocampal functions: thewherematters
(Wiley, 2022-04)
In the brain, hippocampal circuits are crucial for cognitive performance (e.g., memory) and deeply affected in pathological conditions (e.g., epilepsy, Alzheimer). Specialized molecular mechanisms regulate different cell ...
Oligodendroglial Energy Metabolism and (re)Myelination
(MDPI, 2021-03-13)
Central nervous system (CNS) myelin has a crucial role in accelerating the propagation of action potentials and providing trophic support to the axons. Defective myelination and lack of myelin regeneration following ...
Specific Hippocampal Interneurons Shape Consolidation of Recognition Memory
(Cell Press, 2020-08-18)
A complex array of inhibitory interneurons tightly controls hippocampal activity, but how such diversity specifically affects memory processes is not well understood. We find that a small subclass of type 1 cannabinoid ...