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The 2018 biomembrane curvature and remodeling roadmap
(IOP Publishing, 2018-08-30)
The importance of curvature as a structural feature of biological membranes has been recognized for many years and has fascinated scientists from a wide range of different backgrounds. On the one hand, changes in membrane ...
In-Depth Proteomic Characterization of Classical and Non-Classical Monocyte Subsets
(MDPI, 2018-02-05)
Monocytes are bone marrow-derived leukocytes that are part of the innate immune system. Monocytes are divided into three subsets: classical, intermediate and non-classical, which can be differentiated by their expression ...
What to consider when pseudohypoparathyroidism is ruled out: iPPSD and differential diagnosis
(Biomed Central, 2018-03-02)
Background: Pseudohypoparathyroidism (PHP) is a rare disease whose phenotypic features are rather difficult to identify in some cases. Thus, although these patients may present with the Albright's hereditary osteodystrophy ...
Multiscale modelization in a small virus: Mechanism of proton channeling and its role in triggering capsid disassembly
(Public Library Science, 2018-04)
In this work, we assess a previously advanced hypothesis that predicts the existence of ion channels in the capsid of small and non-enveloped icosahedral viruses. With this purpose we examine Triatoma Virus (TrV) as a case ...
Repurposing ciclopirox as a pharmacological chaperone active against congenital erythropoietic porphyria.
(2018-10-19)
La porfiria eritropoyética congénita es una enfermedad rara autosómica recesiva producida por una actividad deficiente en la uroporfirinógeno III sintasa, la cuarta enzima de la ruta biosintética del grupo hemo. La enfermedad ...
Mecanismos de reconocimiento y control de tráfico endosomal por el complejo retrómero.
(2018-12-10)
El retrómero es un complejo multiproteíco que participa en múltiples etapas del tráfico vesicular, controlando el reciclaje de cargos presentes en los endosomas a la membrana plasmática, la red Trans-Golgi, así como a ...
Mechanical and structural studies of internal lipid-containing bacteriophage PRD1.
(2018-06-18)
La protección del genoma viral durante el viaje extracelular es un requisito absoluto para la supervivencia y replicación del virus. Una vez que la partícula viral se une a la célula huésped, puede comenzar la eyección del ...
Metabolic alterations in urine extracellular vesicles are associated to prostate cancer pathogenesis and progression
(Taylor & Francis, 2018-05-07)
Urine contains extracellular vesicles (EVs) that concentrate molecules and protect them from degradation. Thus, isolation and characterisation of urinary EVs could increase the efficiency of biomarker discovery. We have ...
Exploring The Role Of Genome And Structural Ions In Preventing Viral Capsid Collapse During Dehydration
(IOP Publishing, 2018-03-14)
Even though viruses evolve mainly in liquid milieu, their horizontal transmission routes often include episodes of dry environment. Along their life cycle, some insect viruses, such as viruses from the Dicistroviridae ...
A key function for microtubule-associated-protein 6 in activity-dependent stabilisation of actin filaments in dendritic spines
(Nature Publishing, 2018-09-17)
Emerging evidence indicates that microtubule-associated proteins (MAPs) are implicated in synaptic function; in particular, mice deficient for MAP6 exhibit striking deficits in plasticity and cognition. How MAP6 connects ...