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Silencing of Sinusoidal DDR1 Reduces Murine Liver Metastasis by Colon Carcinoma
(Nature, 2020-10-27)
Liver metastasis depends on the collagenous microenvironment generated by hepatic sinusoidal cells (SCs). DDR1 is an atypical collagen receptor linked to tumor progression, but whether SCs express DDR1 and its implication ...
Innate Lymphoid Cells in the Malignant Melanoma Microenvironment
(MDPI, 2020-10-29)
The role of innate lymphoid cells (ILCs) in cancer progression has been uncovered in recent years. ILCs are classified as Type 1, Type 2, and Type 3 ILCs, which are characterized by the transcription factors necessary for ...
Ocoxin osagarri naturalaren eragin antitumorala pankreako minbiziko eta kolon-ondesteko minbiziaren metastasi hepatikoko eredu esperimentaletan.
(2020-12-22)
Pankreako minbiziak eta kolon-ondesteko minbiziaren metastasi hepatikoak heriotza ugari eragiten dituzte urtero. Hauek tratatzeko erabiltzen den teknika nagusienetariko bat kimioterapia da, zeinak pazienteengan zehar-efektu ...
Arming NK cells with chimeric antigen receptors (CARs) for treatment of refractory and/or relapsed hematological cancers: preclinical study to determine the best cell source.
(2020-02-10)
Acute Lymphoblastic Leukemia (ALL) and Chronic Lymphocytic Leukemia (CLL) are the most prevalent hematological cancers in children and elder patients respectively. Sometimes, standard treatments are not enough for curing ...
Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells
(BioMed Central, 2011-10-07)
Background -- N-(4-hydroxyphenyl)retinamide (4-HPR, fenretinide) is a synthetic retinoid with potent pro-apoptotic activity against several types of cancer, but little is known regarding mechanisms leading to chemoresistance. ...
Docosahexaenoic acid reduces cerebral damage and ameliorates long-term cognitive impairments caused by neonatal hypoxia-ischemia in rats
(Springer, 2011-10-29)
As the interest in the neuroprotective possibilities
of docosahexaenoic acid (DHA) for brain injury has grown in the recent years, we aimed to investigate the long-term effects of this fatty acid in an experimental model ...