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Now showing items 221-230 of 231
Role of MCSF-activated microglia in amyloid-associated pathology
(2022-04-01)
Un evento clave que se desarrolla de forma temprana en la enfermedad de Alzheimer (EA) es el acúmulode las formas oligoméricas del péptido ß-amiloide (oAß) en el cerebro. En este estudio, hemosinvestigado el papel de la ...
Retinal thickness as a biomarker of cognitive impairment in manifest Huntington’s disease
(Springer Nature, 2023)
Background
Cognitive decline has been reported in premanifest and manifest Huntington’s disease but reliable biomarkers are lacking. Inner retinal layer thickness seems to be a good biomarker of cognition in other ...
Isolation and Differentiation of Neurons and Glial Cells from Olfactory Epithelium in Living Subjects
(Springer Nature, 2023)
The study of psychiatric and neurological diseases requires the substrate in which the disorders occur, that is, the nervous tissue. Currently, several types of human bio-specimens are being used for research, including ...
Dysautonomia and small fiber neuropathy in post-COVID condition and Chronic Fatigue Syndrome
(BMC, 2023)
Background
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and post-COVID condition can present similarities such as fatigue, brain fog, autonomic and neuropathic symptoms.
Methods
The study included 87 ...
Lithium levels and lifestyle in patients with bipolar disorder: a new tool for self-management
(Springer, 2023-03)
BACKGROUND: Patients should get actively involved in the management of their illness. The aim of this study was to assess the influence of lifestyle factors, including sleep, diet, and physical activity, on lithium levels ...
Combining imaging mass spectrometry and immunohistochemistry to analyse the lipidome of spinal cord inflammation
(Springer Nature, 2024-02)
Inflammation is a complex process that accompanies many pathologies. Actually, dysregulation of the inflammatory process is behind many autoimmune diseases. Thus, treatment of such pathologies may benefit from in-depth ...
Areas of interest and sentiment analysis towards second generation antipsychotics, lithium and mood stabilizing anticonvulsants: Unsupervised analysis using Twitter
(Elsevier, 2024-04)
Background
Severe mental disorders like Schizophrenia and related psychotic disorders (SRD) or Bipolar Disorder (BD) require pharmacological treatment for relapse prevention and quality of life improvement. Yet, treatment ...
A nonlinear meccano for Alzheimer's emergence by amyloid β-mediated glutamatergic hyperactivity
(Elsevier, 2024-05)
The pathophysiological process of Alzheimer's disease (AD) is believed to begin many years before the formal diagnosis of AD dementia. This protracted preclinical phase offers a crucial window for potential therapeutic ...
Oocyte electroporation prior to in vitro fertilization is an efficient method to generate single, double, and multiple knockout porcine embryos of interest in biomedicine and animal production
(Elsevier, 2024-04)
Genetically modified pigs play a critical role in mimicking human diseases, xenotransplantation, and the development of pigs resistant to viral diseases. The use of programmable endonucleases, including the CRISPR/Cas9 ...
Sexually transmitted infections, sexual life and risk behaviours of people living with schizophrenia: systematic review and meta-analysis
(Cambridge University Press, 2024)
Background
Sexually transmitted infections (STIs), along with sexual health and behaviour, have received little attention in schizophrenia patients.
Aims
To systematically review and meta-analytically characterise ...