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Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal
(Cell Press, 2018-04-19)
Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date. Here, we analyzed 575 primary and 335 metastatic biopsies across 100 patients with ...
Dual-Specificity Phosphatases in Neuroblastoma Cell Growth and Differentiation
(MDPI, 2019-03-01)
Dual-specificity phosphatases (DUSPs) are important regulators of neuronal cell growth and differentiation by targeting proteins essential to neuronal survival in signaling pathways, among which the MAP kinases (MAPKs) ...
Soluble PD-L1 Is an Independent Prognostic Factor in Clear Cell Renal Cell Carcinoma
(MDPI, 2021-02-07)
(1). Background: Immunohistochemical (IHC) evaluation of programmed death-1 (PD-1) and its ligand (PD-L1) is being used to evaluate advanced malignancies with potential response to immune checkpoint inhibitors. We evaluated ...
The Labyrinth of Renal Cell Carcinoma
(MDPI, 2020-02-24)
Renal cell carcinoma (RCC) ranks in the top-ten list of malignancies both in males and females [...]
Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness
(Public Library Science, 2015-07-07)
Lymphangioleiomyomatosis (LAM) is a rare lung-metastasizing neoplasm caused by the proliferation of smooth muscle-like cells that commonly carry loss-of-function mutations in either the tuberous sclerosis complex 1 or 2 ...
Protein tyrosine phosphatase modulates cell growth and associates with poor outcome in human neuroblastoma
(BMC, 2019-12-14)
Background Protein tyrosine phosphatases (PTPs) regulate neuronal differentiation and survival, but their expression patterns and functions in human neuroblastoma (NB) are scarcely known. Here, we have investigated the ...
What Accounts for Physical Activity during Pregnancy? A Study on the Sociodemographic Predictors of Self-Reported and Objectively Assessed Physical Activity during the 1st and 2nd Trimesters of Pregnancy
(MDPI, 2020-04-07)
Physical activity (PA) during pregnancy has positive health implications for both mother and child. However, current literature indicates that not all pregnant women meet the international recommendations for PA (at least ...
Meta-Analysis of the Embryo Freezing Transfer Interval
(Wiley, 2021-04)
Background The decision of whether frozen embryo transfer (FET) should be performed in the cycle immediately after OPU or at least one cycle later is controversial. FET could improve pregnancy rates in IVF; however, how ...
Effect of vitamin E administered to men in infertile couples on sperm and assisted reproduction outcomes: a double-blind randomized study
(Elsevier, 2020-12)
Objective: To evaluate the influence on sperm parameters and invitro fertilization (IVF) outcomes of the administration of 400 mg/day of vitamin E for 3 months to men from infertile couples who are undergoing IVF.
Design: ...
Antibacterial and antifungal activity of the human endometrial fluid during the natural cycle
(Hindawi, 2021-06-16)
[EN] Purpose. Some microbiota patterns have been associated with favorable IVF prognosis and others with pathological conditions. The
endometrial fluid aspirate (EFA) contains antibacterial proteins that are enriched in ...