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Truncation-Driven Lateral Association of α-Synuclein Hinders Amyloid Clearance by the Hsp70-Based Disaggregase
(MDPI, 2021-11-30)
The aggregation of α-synuclein is the hallmark of a collective of neurodegenerative disorders known as synucleinopathies. The tendency to aggregate of this protein, the toxicity of its aggregation intermediates and the ...
Hypersensitivity to Pegylated E.coli asparaginase as first-line treatment in contemporary paediatric acute lymphoblastic leukaemia protocols: a meta-analysis of the Ponte di Legno Toxicity working group
(Elsevier, 2022-02)
[EN] BACKGROUND: Hypersensitivity reactions to asparaginase challenge its use and occur frequently (30-75%) after native Escherichia Coli (E.coli) asparaginase. Comparison of incidence of allergic reactions to pegylated ...
Characteristics of white blood cell count in acute lymphoblastic leukemia: A COST LEGEND phenotype-genotype study
(Wiley, 2022-06)
[EN] Background White blood cell count (WBC) as a measure of extramedullary leukemic cell survival is a well-known prognostic factor in acute lymphoblastic leukemia (ALL), but its biology, including impact of host genome ...
Lipid regulation of Atg8 family protein recruitment and membrane modulation of mitophagy and autophagic cell death
(2017-01-20)
Tesi lan honen aurkikuntzek, mitofagian zehar LC3/GABARAP familiako proteinen mitokondrioetarako errekrutatze-prozesuaren mekanismo molekularraren eta Atg8 proteinaren giza ortologoek giza lerro zelular ezberdinetan daukaten ...
The Binding of Aβ42 Peptide Monomers to Sphingomyelin/Cholesterol/Ganglioside Bilayers Assayed by Density Gradient Ultracentrifugation
(MDPI, 2020-02-29)
The binding of Aβ42 peptide monomers to sphingomyelin/cholesterol (1:1 mol ratio) bilayers containing 5 mol% gangliosides (either GM1, or GT1b, or a mixture of brain gangliosides) has been assayed by density gradient ...
Exploring Polar Headgroup Interactions Between Sphingomyelin and Ceramide with Infrared Spectroscopy
(Nature, 2020-10-19)
Ceramide is a major actor in the sphingolipid signaling pathway elicited by various kinds of cell stress. Under those conditions ceramide (Cer) is produced in the plasma membrane as a product of sphingomyelin (SM) hydrolysis, ...
G protein-membrane interactions II: Effect of G Protein-linked Lipids on Membrane Structure and G Protein-membrane Interactions
(Elsevier, 2017-07-03)
[EN] G proteins often bear myristoyl, palmitoyl and isoprenyl moieties, which favor their
association with the membrane and their accumulation in G Protein Coupled Receptor-rich
microdomains. These lipids influence the ...
Phase behaviour of C18-N-acyl sphingolipids, the prevalent species in human brain.
(Elsevier, 2022-11)
Lipidomic analysis of the N-acyl components of sphingolipids in different mammalian tissues had revealed that brain tissue differed from all the other samples in that SM contained mainly C18:0 and C24:1N-acyl chains, and ...
Imaging the early stages of phospholipase C/sphingomyelinase activity on vesicles containing coexisting order-disorder and gel-fluid domains
(Elsevier, 2011-04)
[EN] The binding and early stages of activity of a phospholipase C/sphingomyelinase from Pseudomonas aeruginosa on giant unilamellar vesicles (GUV) have been monitored using fl uorescence confocal microscopy. Both the ...
Lipids in Mitochondrial Macroautophagy: Phase Behavior of Bilayers Containing Cardiolipin and Ceramide
(MDPI, 2023-03-07)
Cardiolipin (CL) is a key lipid for damaged mitochondrial recognition by the LC3/GABARAP human autophagy proteins. The role of ceramide (Cer) in this process is unclear, but CL and Cer have been proposed to coexist in ...