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Hierarchical modelling of patient-reported outcomes data based on the beta-binomial distribution
(2017-12-13)
The beta-binomial distribution does not belong to the exponential family and, hence classical regression techniquescannot be used when dealing with outcomes following the mentioned distribution.In this thesis we propose ...
Wood charcoal analysis of Mesolithic archaeological contexts from Portugal: state of the art
(Arkeogazte: Asociación de Jóvenes Investigadores en Arqueología Prehistórica e Histórica, 2013)
[EN] This paper presents the state of the art of wood charcoal analyses carried out from six Mesolithic
archaeological sites in Portugal. Summarized data allows observing the presence or absence of
wood species in some ...
Detection of Intratumor Heterogeneity in Modern Pathology: A Multisite Tumor Sampling Perspective
(Frontiers Media, 2017-03-06)
Current sampling protocols of neoplasms along the digestive tract and in the urinary bladder have to be updated, as they do not respond to the necessities of modern personalized medicine. We show here that an adapted version ...
S-adenosylmethionine: a metabolic driver in liver lipid metabolism and VLDL clearance
(2017-10-30)
La enfermedad del hígado graso no alcohólica, EHGNA o NAFLD, es la causa más frecuente en el mundo de enfermedad crónica hepática. Su desarrollo se ha asociado en algunos casos a un metabolismo errático de S-Adenosilmetionina ...
The continuity of Roman water supply systems in Post-Roman Spain: the case of Valentia, a reliable example?
(Arkeogazte: Asociación de Jóvenes Investigadores en Arqueología Prehistórica e Histórica, 2011)
[EN] Even if the general assumption is that Roman water supply systems (aqueducts in particular) ceased to function during the late Roman period, and that these were not present in medieval cities, recent archaeological ...
Selective Interaction of Syntaxin 1A with KCNQ2: Possible Implications for Specific Modulation of Presynaptic Activity
(Public Library Science,, 2009-08-13)
KCNQ2/KCNQ3 channels are the molecular correlates of the neuronal M-channels, which play a major role in the control of neuronal excitability. Notably, they differ from homomeric KCNQ2 channels in their distribution pattern ...
Transformation Volume Effects on Shape Memory Alloys
(MDPI, 2013-07-02)
It is generally accepted that the martensitic transformations (MTs) in the shape memory alloys (SMAs) are mainly characterized by the shear deformation of the crystal lattice that arises in the course of MT, while a ...
Endogenous Fishing Mortalities: a State-Space Bioeconomic Model
(Oxford University Press, 2017-05-13)
A methodology that endogenously determines catchability functions that link fi shing mortality with
contemporaneous stock abundance is presented. We consider a stochastic age-structured model for
a fishery composed by ...
Understanding the role of miRNAs in the hallmarks of cancer using functional screens.
(2017-09-15)
En ésta tesis hemos estudiado la función de los miRNAs en las principales características o "hallmarks"del cáncer. Para ello hemos realizado cribados funcionales con una librería lentiviral para la sobreexpresiónde miRNAs ...
State of the Art and Trends Review of Smart Metering in Electricity Grids
(MDPI, 2016-03)
Climate change, awareness of energy efficiency, new trends in electricity markets, the obsolescence of the actual electricity model, and the gradual conversion of consumers to prosumer profiles are the main agents of ...