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Effect of the Enrichment of Corn Oil With alpha- or gamma-Tocopherol on Its In Vitro Digestion Studied by 1H NMR and SPME-GC/MS; Formation of Hydroperoxy-, Hydroxy-, Keto-Dienes and Keto-E-epoxy-E-Monoenes in the More alpha-Tocopherol Enriched Samples
(MDPI, 2020-03-18)
The aim of this study is the analysis of the in vitro digestion of corn oil, and of the effect of its enrichment with three levels of gamma- and alpha-tocopherol, by using, for the first time, 1H nuclear magnetic resonance ...
Nanostructured Lipid Carriers Made of Ω-3 Polyunsaturated Fatty Acids: In Vitro Evaluation of Emerging Nanocarriers to Treat Neurodegenerative Diseases
(MDPI, 2020-09-29)
Neurodegenerative diseases (ND) are one of the main problems of public health systems in the 21st century. The rise of nanotechnology-based drug delivery systems (DDS) has become in an emerging approach to target and treat ...
Oxylipins Associated to Current Diseases Detected for the First Time in the Oxidation of Corn Oil as a Model System of Oils Rich in Omega-6 Polyunsaturated Groups. A Global, Broad and in-Depth Study by 1H NMR Spectroscopy
(MDPI, 2020-06-20)
For the first time, an important number of oxylipins have been identified and quantified in corn oil submitted to mild oxidative conditions at each time of their oxidation process. This oil can be considered as a model ...
Dual effect of TAT functionalized DHAH lipid nanoparticles with neurotrophic factors in human BBB and microglia cultures.
(BMC, 2022-03-17)
[EN] BACKGROUND: Neurodegenerative diseases (NDs) are an accelerating global health problem. Nevertheless, the stronghold of the brain- the blood-brain barrier (BBB) prevents drug penetrance and dwindles effective treatments. ...
Novel nanostructured lipid carriers based on Ω-3 polyunsaturated fatty acids and TAT peptide for neurodegenerative disease treatment
(2020-12-14)
Neurodegenerative diseases (NDs) are an accelerating global problem, but we still lack routes to develop effective therapeutics. In this quest, it is crucial to identify novel drug candidates or drug carriers, which cross ...
Characterization of edible oils main and minor components and study of their evolution during oxidation, nixtamalization and in vitro digestion processes by non-conventional tecniques DI-SPME-GC/MS and1H NMR spectroscopy
(2020-07-27)
En la presente tesis doctoral, por un lado, se abordó el estudio de la caracterización de aceites vegetales de diferente origen botánico, prestando atención a su composición en componentes minoritarios mediante el empleo ...
Impact of Augmented Renal Clearance in Critically Ill Patients: Population Pharmacokinetics of Levetiracetam and Dosing Evaluation
(2022-06-27)
Introduction: Augmented renal clearance (ARC) is a phenomenon recently identified in critically ill patients.ARC has the potential to influence the pharmacokinetic profile of any drug that is renally cleared andknown to ...
Study of the In Vitro Digestion of Olive Oil Enriched or Not with Antioxidant Phenolic Compounds. Relationships between Bioaccessibility of Main Components of Different Oils and Their Composition
(MDPI, 2020-06-20)
The changes provoked by in vitro digestion in the lipids of olive oil enriched or not with different phenolic compounds were studied by proton nuclear magnetic resonance (1H NMR) and solid phase microextraction followed ...
A Global Study by 1H NMR Spectroscopy and SPME-GC/MS of the in Vitro Digestion of Virgin Flaxseed Oil Enriched or not with Mono-, Di- or Tri-Phenolic Derivatives. Antioxidant Efficiency of These Compounds
(MDPI, 2020-04-15)
The effect of enriching virgin flaxseed oil with dodecyl gallate, hydroxytyrosol acetate or gamma-tocopherol on its in vitro digestion is studied by means of proton nuclear magnetic resonance and solid phase microextraction ...
Key Aspects in Nutritional Management of COVID-19 Patients
(MDPI, 2020-08-10)
This review deals with the relationship among nutrition, the immune system, and coronavirus disease 2019 (COVID-19). The influence of nutrients and bioactive molecules present in foodstuffs on immune system activity, the ...