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Now showing items 11-20 of 234
Arquitectura subcelular del sistema endocannabinoide en el núcleo ventromedial del hipotálamo de ratón
(2014-01-30)
El sistema endocannabinoide (eCB) es un complejo sistema endógeno de señalización, que participa en la modulación de la transmisión sináptica en múltiples circuitos cerebrales, incluyendo los que regulan el apetito, ingesta ...
SU-8 microprobes for biomedical applications
(2014-01-30)
[ES]La presente tesis doctoral aborda el diseño, fabricación, encapsulado, y caracterización de microagujas de SU-8 para aplicaciones médicas. En la actualidad existe una amplia variedad de agujas para el registro, ...
Modulación de SOX2 mediante la inhibición de mTOR y su implicación en quimiorresistencia y células madre del cáncer en glioblastoma multiforme
(2016-09-02)
SOX2 es un factor de transcripción ampliamente expresado en el Glioblastoma Multiforme (GBM) y que regula la actividad de las células madre de glioma (GSC). Se desconoce exactamente cuál es su papel en estas células, y su ...
Cannabis use and involuntary admission may mediate long-term adherence in first-episode psychosis patients: a prospective longitudinal study
(BioMed Central, 2013-12-01)
Background: This study aimed to examine factors associated with treatment adherence in first-episode psychosis (FEP) patients followed up over 8 years, especially involuntary first admission and stopping cannabis use.
Methods: ...
GABA release by hippocampal astrocytes
(Frontiers Res Found, 2012-08-17)
Astrocytes can directly influence neuronal activity through the release of various transmitters acting on membrane receptors expressed by neurons. However, in contrast to glutamate and ATP for instance, the release of GABA ...
Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer's disease
(Portland Press, 2011)
The EC (entorhinal cortex) is fundamental for cognitive and mnesic functions. Thus damage to this area appears as a key element in the progression of AD (Alzheimer's disease), resulting in memory deficits arising from ...
Unlike Physical Exercise, Modified Environment Increases the Lifespan of SOD1(G93A) Mice However Both Conditions Induce Cellular Changes
(Public Library of Science, 2012-09-20)
Background: Amyotrophic lateral sclerosis (ALS) is characterized by a gradual muscular paralysis resulting from progressive motoneurons death. ALS etiology remains unknown although it has been demonstrated to be a ...
Neurotransmitter signaling in the pathophysiology of microglia
(Frontiers Research Foundation, 2013)
Microglial cells are the resident immune cells of the central nervous system. In the resting state, microglia are highly dynamic and control the environment by rapidly extending and retracting motile processes. Microglia ...
Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis
(Frontiers Research Foundation, 2013-01)
Microglia are the resident brain macrophages and they have been traditionally studied as orchestrators of the brain inflammatory response during infections and disease. In addition, microglia has a more benign, less explored ...
Increased physical activity is not enough to recover astrocytic population from dark-rearing. Synergy with multisensory enrichment is required
(Frontiers Research Foundation, 2013-10-04)
Elimination of sensory inputs (deprivation) modifies the properties of the sensory cortex and serves as a model for studying plasticity during postnatal development. Many studies on the effects of deprivation have been ...