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Detection of Intratumor Heterogeneity in Modern Pathology: A Multisite Tumor Sampling Perspective
(Frontiers Media, 2017-03-06)
Current sampling protocols of neoplasms along the digestive tract and in the urinary bladder have to be updated, as they do not respond to the necessities of modern personalized medicine. We show here that an adapted version ...
La vía de regulación sonic hedgehog como diana terapéutica en tumores pediátricos malignos del sistema nervioso
(2017-07-21)
La presente tesis propone el estudio de la vía de regulación sonic hedgehog en tumores pediátricos malignos, como son el meduloblastoma y el neuroblastoma. El tema de estudio se introduce mediante una descripción del ...
Human DenPulp Stem Cells Grown in Neurogenic Media Differentiate Into Endothelial Cells and Promote Neovasculogenesis in the Mouse Brain
(Frontiers Media, 2019-03-28)
Dental pulp stem cells (DPSCs) have the capacity to give rise to cells with neuronal-like phenotypes, suggesting their use in brain cell therapies. In the present work, we wanted to address the phenotypic fate of adult ...
Decreased expression of the β2 integrin on tumor cells is associated with a reduction in liver metastasis of colorectal cancer in mice
(Biomed Central, 2017-12-06)
Background: Lymphocyte Function-Associated Antigen-1 (LFA-1; CD18/CD11a) is one of the main adhesion molecules used by immune cells to infiltrate the liver under inflammatory conditions. Recently, the expression of this ...
Development of a cartilage tissue engineering construct based on hASCs spheroids differentiated under hypoxia in a chitosan/chitin nanocrystals 3D scaffold.
(2019-01-14)
The generation of a cartilage tissue engineering (TE) construct is currently a viable strategy for the treatment of osteoarthritis. Such construct requires a biomaterial with optimal properties, including biocompatibility, ...
Evidence of conditioned behavior in amoebae
(Nature, 2019-08-15)
Associative memory is the main type of learning by which complex organisms endowed with evolved nervous systems respond efficiently to certain environmental stimuli. It has been found in different multicellular species, ...
Mecanismos celulares de la regeneración del defecto epitelial corneal tratado con suero derivado de plasma rico en factores de crecimiento (s-PRGF) en solitiario y combinado.
(2018-09-14)
Las propiedades terapéuticas de los derivados hemáticos se basan en su capacidad para estimular lareparación y regeneración de diferentes tejidos, gracias a los factores de crecimiento y proteínasbioactivas presentes en ...
Dexamethasone Protects Retinal Ganglion Cells But Not Muller Glia Against Hyperglycemia In Vitro
(Public Library Science, 2018-11-26)
Diabetic retinopathy (DR) is a common complication of diabetes, for which hyperglycemia is a major etiological factor. It is known that retinal glia (Muller cells) and retinal ganglion cells (RGCs) are affected by diabetes, ...
Análisis de la morbimortalidad a corto y medio plazo en los recién nacidos prematuros pequeños para la edad gestacional
(2017-09-15)
La prematuridad es uno de los mayores desafíos de la medicina perinatal, ya que conlleva en sí misma un alto riesgo de mortalidad y morbilidad, tanto a corto como a largo plazo. El recién nacido pequeño para la edad ...
Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity
(Biomed Central, 2016-08-22)
Background: Histone deacetylase inhibitors (HDACi) exert multiple cytotoxic actions on cancer cells. Currently, different synthetic HDACi are in clinical use or clinical trials; nevertheless, since both pro-invasive and ...