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An Integrative Omics Approach Reveals Involvement of BRCA1 in Hepatic Metastatic Progression of Colorectal Cancer
(MDPI, 2020-08-22)
(1) Background & Aims: The roles of different cells in the tumor microenvironment (TME) are critical to the metastatic process. The phenotypic transformation of the liver cells is one of the most important stages of the ...
Insuficiencia Renal en el Mieloma Múltiple. Análisis de factores pronósticos. Estudio de una serie de 307 pacientes tratados en un Servicio de Medicina Interna
(2017-09-28)
La insuficiencia renal al debut en el Mieloma Multiple sucede entre 20-25% de los casos; y es un factor de mal pronóstico conocido. Hemos realizado un estudio retrospectivo de una cohorte histórica de 307 pacientes, ...
Perinatal hipoxic ischemic injury in the auditory pathway and the effect of several neuroprotective agents
(2015-10-16)
Despite improvements in neonatology, perinatal hypoxic-ischemic (HI) encephalopathy remains one of the main causes of disabilities in term-born infants. This specific pathology underlies many neurological disorders such ...
Dexamethasone Protects Retinal Ganglion Cells But Not Muller Glia Against Hyperglycemia In Vitro
(Public Library Science, 2018-11-26)
Diabetic retinopathy (DR) is a common complication of diabetes, for which hyperglycemia is a major etiological factor. It is known that retinal glia (Muller cells) and retinal ganglion cells (RGCs) are affected by diabetes, ...
Development, Application and Evaluation of an Active Learning Methodology for Health Science Students, Oriented towards Equity and Cultural Diversity in the Treatment and Care of Geriatric Patients
(MDPI, 2022-11-06)
The increased aging of populations and rises in immigration have prompted the design of new methodologies and instruments for fostering the invisible care of geriatric patients among health science students in accordance ...
Characteristics of Whale Muller Glia in Primary and Immortalized Cultures
(Frontiers Media, 2022)
[EN] Muller cells are the principal glial cells in the retina and they assume many of the functions carried out by astrocytes, oligodendrocytes and ependymal cells in other regions of the central nervous system. Muller ...
Effects of Folinic Acid Administration on Lower Limb Ischemia/Reperfusion Injury in Rats
(MDPI, 2021-11-25)
Surgery under ischemic conditions, lasting up to 3 h, is routinely performed in orthopedic surgery, causing undesirable injury due to ischemia-reperfusion syndrome, with short and medium-term functional repercussions. To ...
Effect of Hypoxia on the Retina and Superior Colliculus of Neonatal Pigs
(Public LIbrary Science, 2017-04-13)
Purpose
To evaluate the effect of hypoxia on the neonatal pig retina and brain, we analysed the retinal ganglion cells (RGCs) and neurons in the superior colliculus, as well as the response of astrocytes in both these ...
Effect of Neonatal Asphyxia on the Impairment of the Auditory Pathway by Recording Auditory Brainstem Responses in Newborn Piglets: A New Experimentation Model to Study the Perinatal Hypoxic-Ischemic Damage on the Auditory Syste
(Public Library Science, 2015-05-26)
Introduction
Hypoxia-ischemia (HI) is a major perinatal problem that results in severe damage to the brain impairing the normal development of the auditory system. The purpose of the present study is to study the effect ...
Potential Tear Biomarkers for the Diagnosis of Parkinson’s Disease—A Pilot Study
(MDPI, 2022-01-13)
Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease. In this study, the tear proteome profile of patients with idiopathic PD (iPD, n = 24), carriers of the E46K-SNCA ...