Now showing items 1-8 of 8

    • Thumbnail

      Cannabinoid Control of Olfactory Processes: The Where Matters 

      Terral, Geoffrey; Marsicano, Giovanni; Grandes Moreno, Pedro Rolando; Soria Gómez, Edgar (MDPI, 2020-04-16)
      Olfaction has a direct influence on behavior and cognitive processes. There are different neuromodulatory systems in olfactory circuits that control the sensory information flowing through the rest of the brain. The presence ...
    • Thumbnail

      GABAergic and Cortical and Subcortical Glutamatergic Axon Terminals Contain CB1 Cannabinoid Receptors in the Ventromedial Nucleus of the Hypothalamus 

      Reguero Acebal, Leire; Puente Bustinza, Nagore; Elezgarai Gabantxo, Izaskun; Mendizabal Zubiaga, Juan Luis; Canduela Pérez, Miren Josune; Buceta Salazar, Ianire; Ramos Uriarte, Almudena; Suárez, Juan; Rodríguez de Fonseca, Fernando; Marsicano, Giovanni; Grandes Moreno, Pedro Rolando (Public Library of Science, 2011-10)
      Background: Type-1 cannabinoid receptors (CB1R) are enriched in the hypothalamus, particularly in the ventromedial hypothalamic nucleus (VMH) that participates in homeostatic and behavioral functions including food intake. ...
    • Thumbnail

      Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project 

      GRACE Consortium; DEGESCO Consortium; Alzheimers Dis Neuroimaging Initia; GRACE Study Grp; Martinez de Pancorbo Gomez, Maria de los Angeles; López de Munain Arregui, Adolfo José (Elsevier Science INC, 2019-10)
      Introduction: Large variability among Alzheimer's disease (AD) cases might impact genetic discoveries and complicate dissection of underlying biological pathways. Methods: Genome Research at Fundacio ACE (GR@ACE) is a ...
    • Thumbnail

      Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons 

      López de Maturana, Rakel; Lang, Valérie; Zubiarrain, Amaia; Sousa, Amaya; Vázquez, Nerea; Gorostidi, Ana; Águila, Julio; López de Munain Arregui, Adolfo José; Rodríguez, Manuel; Sánchez-Pernaute, Rosario (Biomed Central, 2016-11-18)
      Background: Mutations in leucine-rich repeat kinase 2 (LRRK2) contribute to both familial and idiopathic forms of Parkinson's disease (PD). Neuroinflammation is a key event in neurodegeneration and aging, and there is ...
    • Thumbnail

      Online psycho-education to the treatment of bipolar disorder: protocol of a randomized controlled trial 

      González Ortega, Itxaso; Ugarte, Amaia; Ruiz de Azúa Garcia, Sonia; Núñez, Nuria; Zubia, Marta; Ponce, Sara; Casla, Patricia; Llano, Josu Xabier; Faria, Ángel; González Pinto Arrillaga, Ana María (Biomed Central, 2016-12-22)
      Background: Bipolar disorder patients frequently present recurrent episodes and often experience subsyndromal symptoms, cognitive impairment and difficulties in functioning, with a low quality of life, illness relapses and ...
    • Thumbnail

      Specific Hippocampal Interneurons Shape Consolidation of Recognition Memory 

      Oliveira da Cruz, Jose F.; Busquets Garcia, Arnau; Zhao, Zhe; Varilh, Marjorie; Lavanco, Gianluca; Bellocchio, Luigi; Robin, Laurie; Cannich, Astrid; Julio Kalajzić, Francisca; Lesté Lasserre, Thierry; Maître, Marlène; Drago, Filippo; Marsicano, Giovanni; Soria Gómez, Edgar (Cell Press, 2020-08-18)
      A complex array of inhibitory interneurons tightly controls hippocampal activity, but how such diversity specifically affects memory processes is not well understood. We find that a small subclass of type 1 cannabinoid ...
    • Thumbnail

      Synucleinopathy alters nanoscale organization anddiffusion in the brain extracellular space throughhyaluronan remodeling 

      Soria Lannes, Federico NIcolás; Paviolo, Chiara; Doudnikoff, Evelyne; Arotcarena, Marie Laure; Lee, Antony; Danné, Noémie; Mandal, Amit Kumar; Gosset, Philippe; Dehay, Benjamin; Groc, Laurent; Cognet, Laurent; Bezard, Erwan (Nature, 2020-07-10)
      In recent years, exploration of the brain extracellular space (ECS) has made remarkable progress, including nanoscopic characterizations. However, whether ECS precise conformation is altered during brain pathology remains ...
    • Thumbnail

      Translating big data to better treatment in bipolar disorder - a manifesto for coordinated action 

      Manchia, Mirko; Vieta, Eduard; Smeland, Olav B.; Altimus, Cara; Bechdolf, Andreas; Bellivier, Frank; Bergink, Veerle; Fagiolini, Andrea; Geddes, John; Hajek, Tomas; Henry, Chantal; Kupka, Ralph; Lagerberg, Trine V.; Licht, Rasmus W.; Martínez Cengotitabengoa, Mónica; Morken, Gunnar; Nielsen, René E.; González Pinto Arrillaga, Ana María; Reif, Andreas; Rietschel, Marcella; Ritter, Philipp; Schulze, Thomas G.; Scott, Jan; Severus, Emanuel; Yildiz, Aysegul; Kessing, Lars Vedel; Bauer, Michael; Goodwin, Guy M.; Andreassen, Ole A. (Elsevier, 2020-06-12)
      [EN] Bipolar disorder (BD) is a major healthcare and socio-economic challenge. Despite its substan- tial burden on society, the research activity in BD is much smaller than its economic impact appears to demand. There is ...