BackExaminar OpenAire por departamento (eus.) "Neurozientziak"
Now showing items 1-13 of 13
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Cannabinoid Control of Olfactory Processes: The Where Matters
Terral, Geoffrey; Marsicano, Giovanni; Grandes Moreno, Pedro Rolando
; Soria Gómez, Edgar (MDPI, 2020-04-16)
Olfaction has a direct influence on behavior and cognitive processes. There are different neuromodulatory systems in olfactory circuits that control the sensory information flowing through the rest of the brain. The presence ... -
Common Variants in Alzheimer’s Disease and Risk Stratification by Polygenic Risk Scores
(Springer, 2021-06-07)Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical ... -
Cortical thinning over two years after first-episode psychosis depends on age of onset.
Pina Camacho, Laura; Martínez, Kenia; Díaz Caneja, Covadonga; Mezquida, Gisela; Cuesta, Manuel J.; Moreno, Carmen; Amoretti, Silvia; González Pinto Arrillaga, Ana María; Arango, Celso; ; Castro Fornieles, Josefina; Lobo, Antonio; Fraguas, David; Bernardo, Miguel; Janssen, Joost; Parellada, Mara; Zorrilla Martínez, Iñaki; PEPs Group (Nature Portfolio, 2022-03-11)
[EN] First-episode psychosis (FEP) patients show structural brain abnormalities at the first episode. Whether the cortical changes that follow a FEP are progressive and whether age at onset modulates these changes remains ... -
GABAergic and Cortical and Subcortical Glutamatergic Axon Terminals Contain CB1 Cannabinoid Receptors in the Ventromedial Nucleus of the Hypothalamus
Reguero Acebal, Leire; Puente Bustinza, Nagore ; Elezgarai Gabantxo, Izaskun ; Mendizabal Zubiaga, Juan Luis ; Canduela Pérez, Miren Josune; Buceta Salazar, Ianire ; Ramos Uriarte, Almudena ; Suárez, Juan; Rodríguez de Fonseca, Fernando; Marsicano, Giovanni; Grandes Moreno, Pedro Rolando (Public Library of Science, 2011-10)
Background: Type-1 cannabinoid receptors (CB1R) are enriched in the hypothalamus, particularly in the ventromedial hypothalamic nucleus (VMH) that participates in homeostatic and behavioral functions including food intake. ... -
Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project
; ; ; ; Martínez de Pancorbo Gómez, María de los Angeles; (Elsevier Science INC, 2019-10)
Introduction: Large variability among Alzheimer's disease (AD) cases might impact genetic discoveries and complicate dissection of underlying biological pathways. Methods: Genome Research at Fundacio ACE (GR@ACE) is a ... -
Impact of social and mobility restrictions in Parkinson's disease during COVID-19 lockdown
(Springer, 2021-08-30)Background The consequences of strict COVID-19 mobility restrictions on motor/non-motor features in Parkinson's disease (PD) have not been systematically studied but worse mobility and quality of life have been reported. ... -
Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons
(Biomed Central, 2016-11-18)Background: Mutations in leucine-rich repeat kinase 2 (LRRK2) contribute to both familial and idiopathic forms of Parkinson's disease (PD). Neuroinflammation is a key event in neurodegeneration and aging, and there is ... -
Online psycho-education to the treatment of bipolar disorder: protocol of a randomized controlled trial
; ; Ruiz de Azúa García, Sonia; ; ; ; ; ; ; González Pinto Arrillaga, Ana María (Biomed Central, 2016-12-22)
Background: Bipolar disorder patients frequently present recurrent episodes and often experience subsyndromal symptoms, cognitive impairment and difficulties in functioning, with a low quality of life, illness relapses and ... -
Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia
Andreu-Bernabeu, Álvaro; Díaz Caneja, Covadonga; Costas, Javier; de Hoyos, Lucía; Stella, Carol; Gurriarán, Xaquín; Alloza, Clara; Fañanás, Lourdes; Bobes, Julio; González Pinto Arrillaga, Ana María; Crespo Facorro, Benedicto; Martorell, Lourdes; Vilella, Elisabet; Muntané, Gerard; Nacher, Juan; Moltó, María Dolores; Aguilar, Eduardo Jesús; Parellada, Mara; Arango, Celso; González Peñas, Javier (Nature Research, 2022-01-10)
[EN] Previous research suggests an association of loneliness and social isolation (LNL-ISO) with schizophrenia. Here, we demonstrate a LNL-ISO polygenic score contribution to schizophrenia risk in an independent case-control ... -
Specific Hippocampal Interneurons Shape Consolidation of Recognition Memory
Oliveira da Cruz, Jose F.; Busquets Garcia, Arnau; Zhao, Zhe; Varilh, Marjorie; Lavanco, Gianluca; Bellocchio, Luigi; Robin, Laurie; Cannich, Astrid; Julio Kalajzić, Francisca; Lesté Lasserre, Thierry; Maître, Marlène; Drago, Filippo; Marsicano, Giovanni; Soria Gómez, Edgar (Cell Press, 2020-08-18)
A complex array of inhibitory interneurons tightly controls hippocampal activity, but how such diversity specifically affects memory processes is not well understood. We find that a small subclass of type 1 cannabinoid ... -
Synucleinopathy alters nanoscale organization anddiffusion in the brain extracellular space throughhyaluronan remodeling
Soria Lannes, Federico Nicolás; Paviolo, Chiara; Doudnikoff, Evelyne; Arotcarena, Marie Laure; Lee, Antony; Danné, Noémie; Mandal, Amit Kumar; Gosset, Philippe; Dehay, Benjamin; Groc, Laurent; Cognet, Laurent; Bezard, Erwan (Nature, 2020-07-10)
In recent years, exploration of the brain extracellular space (ECS) has made remarkable progress, including nanoscopic characterizations. However, whether ECS precise conformation is altered during brain pathology remains ... -
The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis
; ; ; ; ; ; ; González Pinto Arrillaga, Ana María; ; ; ; ; ; ; ; ; ; ; ; ; (MDPI, 2021-06-02)
Background: premorbid IQ (pIQ) and age of onset are predictors of clinical severity and long-term functioning after a first episode of psychosis. However, the additive influence of these variables on clinical, functional, ... -
Translating big data to better treatment in bipolar disorder - a manifesto for coordinated action
Manchia, Mirko; ; Smeland, Olav B.; Altimus, Cara; Bechdolf, Andreas; Bellivier, Frank; Bergink, Veerle; Fagiolini, Andrea; Geddes, John; Hajek, Tomas; Henry, Chantal; Kupka, Ralph; Lagerberg, Trine V.; Licht, Rasmus W.; Martínez Cengotitabengoa, Mónica; Morken, Gunnar; Nielsen, René E.; González Pinto Arrillaga, Ana María ; Reif, Andreas; Rietschel, Marcella; Ritter, Philipp; Schulze, Thomas G.; Scott, Jan; Severus, Emanuel; Yildiz, Aysegul; Kessing, Lars Vedel; Bauer, Michael; Goodwin, Guy M.; Andreassen, Ole A. (Elsevier, 2020-06-12)
[EN] Bipolar disorder (BD) is a major healthcare and socio-economic challenge. Despite its substan- tial burden on society, the research activity in BD is much smaller than its economic impact appears to demand. There is ...