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Behavioral, neurochemical and morphological changes induced by the overexpression of munc18-1a in brain of mice: relevance to schizophrenia

dc.contributor.authorUrigüen Echeverría, Leyre ORCID
dc.contributor.authorGil Pisa, I.
dc.contributor.authorMunarriz Cuezva, Eva
dc.contributor.authorBerrocoso, E.
dc.contributor.authorPascau, J.
dc.contributor.authorSoto Montenegro, María Luisa
dc.contributor.authorGutiérrez Adán, A.
dc.contributor.authorPintado, B.
dc.contributor.authorMadrigal, J. L. M.
dc.contributor.authorCastro, E.
dc.contributor.authorSánchez Blázquez, P.
dc.contributor.authorOrtega, J. E.
dc.contributor.authorGuerrero, M. J.
dc.contributor.authorFerrer Alcon, M.
dc.contributor.authorGarcía Sevilla, J. A.
dc.contributor.authorMico, J. A.
dc.contributor.authorDesco, M.
dc.contributor.authorLeza, Juan Carlos
dc.contributor.authorPazos, A.
dc.contributor.authorGarzon, J.
dc.contributor.authorMeana Martínez, José Javier ORCID
dc.date.accessioned2014-02-07T16:26:42Z
dc.date.available2014-02-07T16:26:42Z
dc.date.issued2013-01
dc.identifier.citationTranslational Psychiatry 3 : (2013) // e221es
dc.identifier.issn2158-3188
dc.identifier.urihttp://hdl.handle.net/10810/11384
dc.description.abstractOverexpression of the mammalian homolog of the unc-18 gene (munc18-1) has been described in the brain of subjects with schizophrenia. Munc18-1 protein is involved in membrane fusion processes, exocytosis and neurotransmitter release. A transgenic mouse strain that overexpresses the protein isoform munc18-1a in the brain was characterized. This animal displays several schizophrenia-related behaviors, supersensitivity to hallucinogenic drugs and deficits in prepulse inhibition that reverse after antipsychotic treatment. Relevant brain areas (that is, cortex and striatum) exhibit reduced expression of dopamine D-1 receptors and dopamine transporters together with enhanced amphetamine-induced in vivo dopamine release. Magnetic resonance imaging demonstrates decreased gray matter volume in the transgenic animal. In conclusion, the mouse overexpressing brain munc18-1a represents a new valid animal model that resembles functional and structural abnormalities in patients with schizophrenia.es
dc.description.sponsorshipBrainco Biopharma SL; Centro de Investigacion Biomedica en Red de Salud Mental; Instituto de Salud Carlos III (CIBERSAM); Spanish MICINN; FEDER SAF2009-08460, SAF2010-21948,AGL2009-11358, SAF2011-29918, PI10/02986, CP08/00017,CEN-20101014; Basque Government PR10UN01 IT-199/07; University of the Basque Country (UPV/EHU); Complutense University of Madrid UCM GR42/10-962075es
dc.language.isoenges
dc.publisherNature Publishing Groupes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectmunc18-1aes
dc.subjectPPIes
dc.subjectschizophreniaes
dc.subjectSNAREes
dc.titleBehavioral, neurochemical and morphological changes induced by the overexpression of munc18-1a in brain of mice: relevance to schizophreniaes
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder(c)2013 Urigüen et al. This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/.es
dc.relation.publisherversionhttp://www.nature.com/tp/journal/v3/n1/full/tp2012149a.htmles
dc.identifier.doi10.1038/tp.2012.149
dc.departamentoesFarmacologíaes_ES
dc.departamentoeuFarmakologiaes_ES
dc.subject.categoriaBIOLOGICAL PSYCHIATRY
dc.subject.categoriaPSYCHIATRY AND MENTAL HEALTH
dc.subject.categoriaCELLULAR AND MOLECULAR NEUROSCIENCE


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