UPV-EHU ADDI
  • Back
    • English
    • Español
    • Euskera
  • Login
  • English 
    • English
    • Español
    • Euskera
  • FAQ
View Item 
  •   Home
  • INVESTIGACIÓN
  • Artículos, Comunicaciones, Libros
  • Artículos
  • View Item
  •   Home
  • INVESTIGACIÓN
  • Artículos, Comunicaciones, Libros
  • Artículos
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

ICGE: an R package for detecting relevant clusters and atypical units in gene expression

Thumbnail
View/Open
1471-2105-13-30.pdf (827.8Kb)
Date
2012-02
Author
Irigoyen Garbizu, Itziar
Sierra Araujo, Basilio
Arenas Solá, Concepción
Metadata
Show full item record
BMC Bioinformatics 13 : (2012) // Article nº 30
URI
http://hdl.handle.net/10810/11567
Abstract
Background: Gene expression technologies have opened up new ways to diagnose and treat cancer and other diseases. Clustering algorithms are a useful approach with which to analyze genome expression data. They attempt to partition the genes into groups exhibiting similar patterns of variation in expression level. An important problem associated with gene classification is to discern whether the clustering process can find a relevant partition as well as the identification of new genes classes. There are two key aspects to classification: the estimation of the number of clusters, and the decision as to whether a new unit (gene, tumor sample ... ) belongs to one of these previously identified clusters or to a new group. Results: ICGE is a user-friendly R package which provides many functions related to this problem: identify the number of clusters using mixed variables, usually found by applied biomedical researchers; detect whether the data have a cluster structure; identify whether a new unit belongs to one of the pre-identified clusters or to a novel group, and classify new units into the corresponding cluster. The functions in the ICGE package are accompanied by help files and easy examples to facilitate its use. Conclusions: We demonstrate the utility of ICGE by analyzing simulated and real data sets. The results show that ICGE could be very useful to a broad research community.
Collections
  • Artículos

DSpace software copyright © 2002-2015  DuraSpace
OpenAIRE
OpenAIRE
 

 

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesDepartamentos (cas.)Departamentos (eus.)SubjectsThis CollectionBy Issue DateAuthorsTitlesDepartamentos (cas.)Departamentos (eus.)Subjects

My Account

Login

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
OpenAIRE
OpenAIRE