dc.contributor.author | García-González, María Asunción | |
dc.contributor.author | Nicolás-Pérez, David | |
dc.contributor.author | Lanas, Ángel | |
dc.contributor.author | Bujanda Fernández de Pierola, Luis | |
dc.contributor.author | Carrera, Patricia | |
dc.contributor.author | Benito, Rafael | |
dc.contributor.author | Strunk, Mark | |
dc.contributor.author | Sopeña, Federico | |
dc.contributor.author | Santolaria, Santos | |
dc.contributor.author | Piazuelo, Elena | |
dc.contributor.author | Jiménez, Pilar | |
dc.contributor.author | Campo, Rafael | |
dc.contributor.author | Espinel, Jesús | |
dc.contributor.author | Manzano, Marisa | |
dc.contributor.author | Geijo, Fernando | |
dc.contributor.author | Pellisé, María | |
dc.contributor.author | González-Huix, Ferrán | |
dc.contributor.author | Espinós, Jorge | |
dc.contributor.author | Zaballa, Manuel | |
dc.contributor.author | Titó, Llúcia | |
dc.contributor.author | Barranco, Luis | |
dc.contributor.author | Pazo, Roberto | |
dc.contributor.author | Quintero, Enrique | |
dc.date.accessioned | 2014-02-25T18:30:45Z | |
dc.date.available | 2014-02-25T18:30:45Z | |
dc.date.issued | 2012-09-28 | |
dc.identifier.citation | PLoS ONE 7(9) : (2012) // e46179 | es |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/10810/11646 | |
dc.description | 11 p. | es |
dc.description.abstract | Background: Genetic factors influencing the prognosis of gastric adenocarcinoma (GAC) are not well known. Given the relevance of cytokines and other pro-inflammatory mediators in cancer progression and invasiveness, we aimed to assess the prognostic role of several functional cytokine and cyclooxygenase gene polymorphisms in patients with GAC. -- Methodology: Genomic DNA from 380 Spanish Caucasian patients with primary GAC was genotyped for 23 polymorphisms in pro-inflammatory (IL1B, TNFA, LTA, IL6, IL12p40), anti-inflammatory (IL4, IL1RN, IL10, TGFB1) cytokine, and cyclooxygenase (PTGS1 and PTGS2) genes by PCR, RFLP and TaqMan assays. Clinical and histological information was collected prospectively. Survival curves were estimated by the Kaplan-Meier method and compared using the log rank test. Outcome was determined by analysis of Cox proportional hazards, adjusting for confounding factors. --
Results: The median follow-up period and median overall survival (OS) time were 9.9 months (range 0.4-120.3) and 10.9 months (95% CI: 8.9-14.1), respectively. Multivariate analysis identified tumor stages III (HR, 3.23; 95% CI: 2-5.22) and IV (HR, 5.5; 95% CI: 3.51-8.63) as independent factors associated with a significantly reduced OS, whereas surgical treatment (HR: 0.44; 95% CI: 0.3-0.6) was related to a better prognosis of the disease. Concerning genetic factors, none of the 23 polymorphisms evaluated in the current study did influence survival. Moreover, no gene-environment interactions on GAC prognosis were observed. --
Conclusions: Our results show that, in our population, the panel of selected pro-and anti-inflammatory cytokine, and cyclooxygenase gene polymorphisms are not relevant in determining the prognosis of gastric adenocarcinoma. | es |
dc.description.sponsorship | This study was supported by the Spanish "Fondo de Investigaciones Sanitarias" (grants PI05/0405 and PS09/00213), and Instituto de Salud Carlos III (CIBER de enfermedades hepaticas y digestivas). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | es |
dc.language.iso | eng | es |
dc.publisher | Public Library of Science | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | breast-cancer | es |
dc.subject | cancer treatment | es |
dc.subject | carcinoma | es |
dc.subject | cell lung-cancer | es |
dc.subject | colorectal-cancer | es |
dc.subject | cytokines | es |
dc.subject | gastroesophageal cancer | es |
dc.subject | helicobacter-pylori infection | es |
dc.subject | peptic-ulcer disease | es |
dc.subject | polymorphisms | es |
dc.subject | prognosis | es |
dc.subject | smoking habits | es |
dc.subject | surgical and invasive medical procedures | es |
dc.subject | variant genotypes | es |
dc.title | Prognostic Role of Host Cyclooxygenase and Cytokine Genotypes in a Caucasian Cohort of Patients with Gastric Adenocarcinoma | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | © García-González et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | es |
dc.relation.publisherversion | http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0046179 | es |
dc.identifier.doi | 10.1371/journal.pone.0046179 | |
dc.departamentoes | Medicina | es_ES |
dc.departamentoeu | Medikuntza | es_ES |
dc.subject.categoria | AGRICULTURAL AND BIOLOGICAL SCIENCES | |
dc.subject.categoria | MEDICINE | |
dc.subject.categoria | BIOCHEMISTRY AND MOLECULAR BIOLOGY | |