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dc.contributor.authorFernández Martínez, Manuel
dc.contributor.authorElcoroaristizabal Martín, Xabier
dc.contributor.authorGaldos Alcelay, Luis
dc.contributor.authorCastro Flores, Jessica
dc.contributor.authorUterga Valiente, Juan MarÍa
dc.contributor.authorIndakoetxea Juanbeltz, Begoña
dc.contributor.authorGómez Beldarrain, María Angeles
dc.contributor.authorMoraza López, Josefa
dc.contributor.authorGonzález Fernández, María Carmen
dc.contributor.authorMolano Salazar, Ana
dc.contributor.authorBereincua Gandarias, Rocío
dc.contributor.authorInglés Borda, Sandra
dc.contributor.authorOrtiz Marqués, Nuria
dc.contributor.authorBarandiaran Amillano, Miryam
dc.contributor.authorCarrasco Zabaleta, María
dc.contributor.authorMartínez de Pancorbo Gómez, María de los Angeles
dc.date.accessioned2014-04-01T16:22:45Z
dc.date.available2014-04-01T16:22:45Z
dc.date.issued2009-09
dc.identifier.citationBMC Neuroscience 10 : (2009) // Article n. 125es
dc.identifier.issn1471-2202
dc.identifier.urihttp://hdl.handle.net/10810/11904
dc.description.abstractBackground: The aim of this study is to examine the influence of the catechol-O-methyltranferase (COMT) gene (polymorphism Val158 Met) as a risk factor for Alzheimer's disease (AD) and mild cognitive impairment of amnesic type (MCI), and its synergistic effect with the apolipoprotein E gene (APOE). A total of 223 MCI patients, 345 AD and 253 healthy controls were analyzed. Clinical criteria and neuropsychological tests were used to establish diagnostic groups. The DNA Bank of the University of the Basque Country (UPV-EHU) (Spain) determined COMT Val158 Met and APOE genotypes using real time polymerase chain reaction (rtPCR) and polymerase chain reaction (PCR), and restriction fragment length polymorphism (RFLPs), respectively. Multinomial logistic regression models were used to determine the risk of AD and MCI. Results: Neither COMT alleles nor genotypes were independent risk factors for AD or MCI. The high activity genotypes (GG and AG) showed a synergistic effect with APOE epsilon 4 allele, increasing the risk of AD (OR = 5.96, 95% CI 2.74-12.94, p < 0.001 and OR = 6.71, 95% CI 3.36-13.41, p < 0.001 respectivily). In AD patients this effect was greater in women. In MCI patients such as synergistic effect was only found between AG and APOE epsilon 4 allele (OR = 3.21 95% CI 1.56-6.63, p = 0.02) and was greater in men (OR = 5.88 95% CI 1.69-20.42, p < 0.01). Conclusion: COMT (Val158 Met) polymorphism is not an independent risk factor for AD or MCI, but shows a synergistic effect with APOE epsilon 4 allele that proves greater in women with AD.es
dc.description.sponsorshipSupported in part by grants from Federacion de Asociaciones de Familiares de Enfermos de Azheimer de Euskadi, Fondo de Investigacion Sanitaria del Instituto Carlos III ( Madrid), Pfizer Foundation and Ayudas a la Investigacion de la Obra Social de la Caja Vital Kutxa.es
dc.language.isoenges
dc.publisherBioMed Centrales
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectestrogen replacement therapyes
dc.subjectgenotypees
dc.subjectdeclinees
dc.subjectallelees
dc.subjectgeneses
dc.subjectagees
dc.subjectconversiones
dc.subjecthaplotypeses
dc.subjectpsychosises
dc.subjectepsilon-4es
dc.titleThe COMT Val158 Met polymorphism as an associated risk factor for Alzheimer disease and mild cognitive impairment in APOE 4 carrierses
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2009 Martínez et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.es
dc.relation.publisherversionhttp://www.biomedcentral.com/1471-2202/10/125es
dc.identifier.doi10.1186/1471-2202-10-125
dc.departamentoesZoología y biología celular animales_ES
dc.departamentoeuZoologia eta animalia zelulen biologiaes_ES
dc.subject.categoriaCELLULAR AND MOLECULAR NEUROSCIENCE


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