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dc.contributor.authorAguirre López, Leixuri ORCID
dc.contributor.authorFernández Quintela, Alfredo ORCID
dc.contributor.authorArias Rueda, Noemí
dc.contributor.authorPortillo Baquedano, María Puy ORCID
dc.date.accessioned2015-10-16T12:24:11Z
dc.date.available2015-10-16T12:24:11Z
dc.date.issued2014-11
dc.identifier.citationMolecules 19(11) : 18632-18655 (2014)es
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10810/15915
dc.description.abstractResveratrol is a non-flavonoid polyphenol which belongs to the stilbenes group and is produced naturally in several plants in response to injury or fungal attack. Resveratrol has been recently reported as preventing obesity. The present review aims to compile the evidence concerning the potential mechanisms of action which underlie the anti-obesity effects of resveratrol, obtained either in cultured cells lines and animal models. Published studies demonstrate that resveratrol has an anti-adipogenic effect. A good consensus concerning the involvement of a down-regulation of C/EBPa and PPAR. in this effect has been reached. Also, in vitro studies have demonstrated that resveratrol can increase apoptosis in mature adipocytes. Furthermore, different metabolic pathways involved in triacylglycerol metabolism in white adipose tissue have been shown to be targets for resveratrol. Both the inhibition of de novo lipogenesis and adipose tissue fatty acid uptake mediated by lipoprotein lipase play a role in explaining the reduction in body fat which resveratrol induces. As far as lipolysis is concerned, although this compound per se seems to be unable to induce lipolysis, it increases lipid mobilization stimulated by beta-adrenergic agents. The increase in brown adipose tissue thermogenesis, and consequently the associated energy dissipation, can contribute to explaining the body-fat lowering effect of resveratrol. In addition to its effects on adipose tissue, resveratrol can also acts on other organs and tissues. Thus, it increases mitochondriogenesis and consequently fatty acid oxidation in skeletal muscle and liver. This effect can also contribute to the body-fat lowering effect of this molecule.es
dc.description.sponsorshipThis study was supported by grants from Ministerio de Economia y Competitividad (AGL2011-27406-ALI), Instituto de Salud Carlos III (CIBERobn), and University of the Basque Country (UPV/EHU) (IT-572-13 and ELDUNANOTEK UFI11/32).es
dc.language.isoenges
dc.publisherMDPIes
dc.relationinfo:eu-repo/grantAgreement/MINECO/AGL2011-27406-ALI
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectresveratroles
dc.subjectadipogenesises
dc.subjectapoptosises
dc.subjectlipogenesises
dc.subjectlipolysises
dc.subjectthermogenesises
dc.subjectfatty acid oxidationes
dc.subjectadipose triglyceride lipasees
dc.subjectactiones
dc.subject3T3-L1 adipocyteses
dc.subjecttranscriptional controles
dc.subjectdietary polyphenolses
dc.subjectenergy-metabolismes
dc.subjectfat movilizationes
dc.subjecttissuees
dc.subjectexpressiones
dc.subjectobesityes
dc.titleResveratrol: Anti-Obesity Mechanisms of Actiones
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).es
dc.relation.publisherversionhttp://www.mdpi.com/1420-3049/19/11/18632es
dc.identifier.doi10.3390/molecules191118632
dc.departamentoesFarmacia y ciencias de los alimentoses_ES
dc.departamentoeuFarmazia eta elikagaien zientziakes_ES
dc.subject.categoriaCHEMISTRY, ORGANIC


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