dc.contributor.author | Jiménez Agüero, Raúl | |
dc.contributor.author | Emparanza, José Ignacio | |
dc.contributor.author | Beguiristain Gómez, Adolfo | |
dc.contributor.author | Bujanda Fernández de Pierola, Luis | |
dc.contributor.author | Alustiza Echeberria, José María | |
dc.contributor.author | García, Elisabeth | |
dc.contributor.author | Hijona Muruamendiaraz, Elizabeth | |
dc.contributor.author | Gallego, Lander | |
dc.contributor.author | Sanchez Gonzalez, Javier | |
dc.contributor.author | Perugorria Montiel, María Jesús | |
dc.contributor.author | Asensio, José I | |
dc.contributor.author | Larburu Echaniz, Santiago | |
dc.contributor.author | Garmendia Antin, Maddi | |
dc.contributor.author | Larzabal, Mikel | |
dc.contributor.author | Portillo Baquedano, María Puy | |
dc.contributor.author | Aguirre López, Leixuri | |
dc.contributor.author | Bañales Asurmendi, Jesús María | |
dc.date.accessioned | 2015-11-18T15:04:08Z | |
dc.date.available | 2015-11-18T15:04:08Z | |
dc.date.issued | 2014-08-26 | |
dc.identifier.citation | BMC Medicine 12 : (2014) // Article ID 137 | es |
dc.identifier.issn | 1741-7015 | |
dc.identifier.uri | http://hdl.handle.net/10810/16116 | |
dc.description.abstract | Background: Non-alcoholic fatty liver disease (NAFLD) is caused by abnormal accumulation of lipids within liver cells. Its prevalence is increasing in developed countries in association with obesity, and it represents a risk factor for non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma. Since NAFLD is usually asymptomatic at diagnosis, new non-invasive approaches are needed to determine the hepatic lipid content in terms of diagnosis, treatment and control of disease progression. Here, we investigated the potential of magnetic resonance imaging (MRI) to quantitate and monitor the hepatic triglyceride concentration in humans.
Methods: A prospective study of diagnostic accuracy was conducted among 129 consecutive adult patients (97 obesity and 32 non-obese) to compare multi-echo MRI fat fraction, grade of steatosis estimated by histopathology, and biochemical measurement of hepatic triglyceride concentration (that is, Folch value).
Results: MRI fat fraction positively correlates with the grade of steatosis estimated on a 0 to 3 scale by histopathology. However, this correlation value was stronger when MRI fat fraction was linked to the Folch value, resulting in a novel equation to predict the hepatic triglyceride concentration (mg of triglycerides/g of liver tissue = 5.082 + (432.104 * multi-echo MRI fat fraction)). Validation of this formula in 31 additional patients (24 obese and 7 controls) resulted in robust correlation between the measured and estimated Folch values. Multivariate analysis showed that none of the variables investigated improves the Folch prediction capacity of the equation. Obese patients show increased steatosis compared to controls using MRI fat fraction and Folch value. Bariatric surgery improved MRI fat fraction values and the Folch value estimated in obese patients one year after surgery.
Conclusions: Multi-echo MRI is an accurate approach to determine the hepatic lipid concentration by using our novel equation, representing an economic non-invasive method to diagnose and monitor steatosis in humans. | es |
dc.description.sponsorship | This research was supported by grants from: the Spanish Ministry of Economy and Competitiveness (J. M. Banales: FIS PI12/00380, R. Jimenez: FIS PI10/01984), the Spanish Carlos III Health Institute (ISCIII) (J. M. Banales, L. Bujanda: Ciberehd), and the Spanish Association Against Cancer (AECC: J. M. Banales, L. Bujanda); the Department of Industry of the Basque Country (J. M. Banales: SAIO12-PE12BN002); the Health Department of the Basque Country (R. Jimenez: Exp 2010111043); the Department of Education, Universities and Research of the Basque Country (M. P. Portillo: IT-572-13), and the University of the Basque Country (M. P. Portillo: UFI 11/32, ELDUNANOTEK). CIBER-ESP, CIBER-obn, and CIBERehd are funded by the Spanish Carlos III Health Institute (ISCIII). | es |
dc.language.iso | eng | es |
dc.publisher | Biomed Central | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | fatty liver-disease | es |
dc.subject | magnetic-resonance | es |
dc.subject | quantitative assessment | es |
dc.subject | nonalcoholic steatohepatitis | es |
dc.subject | steatosis quantification | es |
dc.subject | 1.5 T | es |
dc.subject | spectroscopy | es |
dc.subject | fraction | es |
dc.subject | variability | es |
dc.subject | histology | es |
dc.title | Novel equation to determine the hepatic triglyceride concentration in humans by MRI: diagnosis and monitoring of NAFLD in obese patients before and after bariatric surgery | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | © 2014 Jiménez-Agüero et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the
Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use,
distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public
Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this
article, unless otherwise stated. | es |
dc.relation.publisherversion | http://www.biomedcentral.com/1741-7015/12/137 | es |
dc.identifier.doi | 10.1186/s12916-014-0137-y | |
dc.departamentoes | Medicina | es_ES |
dc.departamentoes | Cirugía, radiología y medicina física | es_ES |
dc.departamentoeu | Medikuntza | es_ES |
dc.departamentoeu | Kirurgia,erradiologia eta medikuntza fisikoa | es_ES |
dc.subject.categoria | MEDICINE | |