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dc.contributor.authorBarceló Coblijn, Gwendolyn
dc.contributor.authorFernández González, José Andrés
dc.date.accessioned2015-11-20T18:32:34Z
dc.date.available2015-11-20T18:32:34Z
dc.date.issued2015-01-21
dc.identifier.citationFrontiers in Physiology 6: (2015) // Article Number 003es
dc.identifier.issn1664-042X
dc.identifier.urihttp://hdl.handle.net/10810/16140
dc.description.abstractThese are definitively exciting times for membrane lipid researchers. Once considered just as the cell membrane building blocks, the important role these lipids play is steadily being acknowledged. The improvement occurred in mass spectrometry techniques (MS) allows the establishment of the precise lipid composition of biological extracts. However, to fully understand the biological function of each individual lipid species, we need to know its spatial distribution and dynamics. In the past 10 years, the field has experienced a profound revolution thanks to the development of MS-based techniques allowing lipid imaging (MSI). Images reveal and verify what many lipid researchers had already shown by different means, but none as convincing as an image: each cell type presents a specific lipid composition, which is highly sensitive to its physiological and pathological state. While these techniques will help to place membrane lipids in the position they deserve, they also open the black box containing all the unknown regulatory mechanisms accounting for such tailored lipid composition. Thus, these results urges to different disciplines to redefine their paradigm of study by including the complexity revealed by the MSI techniques.es
dc.description.sponsorshipThis work was supported by the Instituto Carlos III (Ministerio de Economía y Competitividad) CP12/03338, Gwendolyn Barceló-Coblijn holds a “Miguel Servet” contract from the Instituto Carlos III. Technical support and personnel provided by the Servicio de Lipidómica of the SGIKER (UPV/EHU, MICINN, GV/E.G., ESF) is gratefully acknowledged.es
dc.language.isoenges
dc.publisherFrontiers Research Foundationes
dc.relationinfo:eu-repo/grantAgreement/MINECO/CP12/03338
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectelectrospray mass spectrometryes
dc.subjecthumanes
dc.subjectimage qualityes
dc.subjectimaging and displayes
dc.subjectlimit of detectiones
dc.subjectlipid analysises
dc.subjectlipid compositiones
dc.subjectlipid oxidationes
dc.subjectmatrix assisted laser desorption ionization time of flight mass spectrometryes
dc.subjectmeasurement accuracyes
dc.subjectmolecular stabilityes
dc.subjectreproducibilityes
dc.subjectsensitivity and specificityes
dc.subjectspatial resolutiones
dc.subjecttandem mass spectrometryes
dc.titleMass spectrometry coupled to imaging techniques: The better the view the greater the challengees
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2015 Barceló-Coblijn and Fernández. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.es
dc.relation.publisherversionhttp://journal.frontiersin.org/article/10.3389/fphys.2015.00003/abstractes
dc.identifier.doi10.3389/fphys.2015.00003
dc.departamentoesQuímica físicaes_ES
dc.departamentoeuKimika fisikoaes_ES
dc.subject.categoriaPHYSIOLOGY
dc.subject.categoriaPHYSIOLOGY (MEDICAL)


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