dc.contributor.author | Cubero, Meritxell | |
dc.contributor.author | Cuervo, Guillermo | |
dc.contributor.author | Domínguez, M. Angeles | |
dc.contributor.author | Tubau, Fe | |
dc.contributor.author | Martí, Sara | |
dc.contributor.author | Sevillano Peña, Elena | |
dc.contributor.author | Gallego Andrés, Lucía | |
dc.contributor.author | Ayats, Josefina | |
dc.contributor.author | Peña, Carmen | |
dc.contributor.author | Pujol, Miquel | |
dc.contributor.author | Linares, Josefina | |
dc.contributor.author | Ardanuy, Carmen | |
dc.date.accessioned | 2016-01-22T19:12:36Z | |
dc.date.available | 2016-01-22T19:12:36Z | |
dc.date.issued | 2015-09-03 | |
dc.identifier.citation | Bmc Microbiology 15 : (2015) // Article ID 177 | es |
dc.identifier.issn | 1471-2180 | |
dc.identifier.uri | http://hdl.handle.net/10810/16806 | |
dc.description.abstract | Background: In this study we describe the clinical and molecular characteristics of an outbreak due to carbapenem-resistant Klebsiella pneumoniae (CR-KP) producing CTX-M-15 and OXA-48 carbapenemase. Isogenic strains, carbapenem-susceptible K. pneumoniae (CS-KP) producing CTX-M-15, were also involved in the outbreak.
Results: From October 2010 to December 2012 a total of 62 CR-KP and 23 CS-KP were isolated from clinical samples of 42 patients (22 had resistant isolates, 14 had susceptible isolates, and 6 had both CR and CS isolates). All patients had underlying diseases and 17 of them (14 patients with CR-KP and 3 with CS-KP) had received carbapenems previously. The range of carbapenem MICs for total isolates were: imipenem: 2 to >32 mu g/ml vs. <2 mu g/ml; meropenem: 4 to >32 mu g/ml vs. <2 mu g/ml; and ertapenem: 8 to >32 mu g/ml vs. <2 mu g/ml. All the isolates were also resistant to gentamicin, ciprofloxacin, and cotrimoxazole. Both types of isolates shared a common PFGE pattern associated with the multilocus sequence type 101 (ST101). The bla(CTX-M-15) gene was detected in all the isolates, whereas the bla(OXA-48) gene was only detected in CR-KP isolates on a 70 kb plasmid.
Conclusions: The clonal spread of K. pneumoniae ST101 expressing the OXA-48 and CTX-M-15 beta-lactamases was the cause of an outbreak of CR-KP infections. CTX-M-15-producing isolates lacking the blaOXA-48 gene coexisted during the outbreak. | es |
dc.description.sponsorship | This study was supported by CIBER de Enfermedades Respiratorias (CIBERES - CB06/06/0037), ISCIII - Instituto de Salud Carlos III, Madrid, Spain. | es |
dc.language.iso | eng | es |
dc.publisher | BioMed Central | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | spetrum beta-lactamases | es |
dc.subject | molecular epidemiology | es |
dc.subject | OXA-48 carbapenemase | es |
dc.subject | escheria cpli | es |
dc.subject | enterobacteriaceae | es |
dc.subject | outbreak | es |
dc.subject | Spain | es |
dc.subject | imipenem | es |
dc.subject | efficacy | es |
dc.subject | criteria | es |
dc.title | Carbapenem-resistant and carbapenem-susceptible isogenic isolates of Klebsiella pneumoniae ST101 causing infection in a tertiary hospital | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | © 2015 Cubero et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a
link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain
Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this
article, unless otherwise stated. | es |
dc.relation.publisherversion | http://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-015-0510-9 | es |
dc.identifier.doi | 10.1186/s12866-015-0510-9 | |
dc.departamentoes | Inmunología, microbiología y parasitología | es_ES |
dc.departamentoeu | Immunologia, mikrobiologia eta parasitologia | es_ES |
dc.subject.categoria | MICROBIOLOGY | |