dc.contributor.author | Gantz, Stephanie C. | |
dc.contributor.author | Levitt, Erica S. | |
dc.contributor.author | Llamosas Muñozguren, Nerea | |
dc.contributor.author | Neve, Kim A. | |
dc.contributor.author | Williams, John T. | |
dc.date.accessioned | 2016-04-07T10:30:44Z | |
dc.date.available | 2016-04-07T10:30:44Z | |
dc.date.issued | 2015-08-11 | |
dc.identifier.citation | Cell Reports 12(6) : 944-954 (2014) | es |
dc.identifier.issn | 2211-1247 | |
dc.identifier.uri | http://hdl.handle.net/10810/17824 | |
dc.description.abstract | Imbalance between the dopamine and serotonin (5-HT) neurotransmitter systems has been implicated in the comorbidity of Parkinson's disease (PD) and psychiatric disorders. L-DOPA, the leading treatment of PD, facilitates the production and release of dopamine. This study assessed the action of L-DOPA on monoamine synaptic transmission in mouse brain slices. Application of L-DOPA augmented the D2-receptor-mediated inhibitory postsynaptic current (IPSC) in dopamine neurons of the substantia nigra. This augmentation was largely due to dopamine release from 5-HT terminals. Selective optogenetic stimulation of 5-HT terminals evoked dopamine release, producing D2-receptor-mediated IPSCs following treatment with L-DOPA. In the dorsal raphe, L-DOPA produced a long-lasting depression of the 5-HT1A-receptor-mediated IPSC in 5-HT neurons. When D2 receptors were expressed in the dorsal raphe, application of L-DOPA resulted in a D2-receptor-mediated IPSC. Thus, treatment with L-DOPA caused ectopic dopamine release from 5-HT terminals and a loss of 5-HT-mediated synaptic transmission. | es |
dc.description.sponsorship | This work was supported by NIH DA04523 and DA034388 (J.T.W.) and by Merit Review Award BX000810 from the US Department of Veterans Affairs Biomedical Laboratory Research and Development (K.A.N.). We thank Drs. Tianyi Mao and Mark Pennesi for supplying Ai9 and Ai32 mice, and 5-HT1B receptor KO mice, respectively, and Maozhen Qin for help with mouse husbandry. | es |
dc.language.iso | eng | es |
dc.publisher | Cell Press | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | rat substantia-nigra | es |
dc.subject | dorsal raphe nucleus | es |
dc.subject | parinsons-disease | es |
dc.subject | cerbrospinal-fluid | es |
dc.subject | induced dyskinesia | es |
dc.subject | amino-acid | es |
dc.subject | in-vitro | es |
dc.subject | neurons | es |
dc.subject | receptor | es |
dc.subject | release | es |
dc.title | Depression of Serotonin Synaptic Transmission by the Dopamine Precursor L-DOPA | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | © 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | es |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S2211124715007317 | es |
dc.identifier.doi | 10.1016/j.celrep.2015.07.005 | |
dc.departamentoes | Farmacología | es_ES |
dc.departamentoeu | Farmakologia | es_ES |
dc.subject.categoria | BIOCHEMISTRY AND MOLECULAR BIOLOGY | |