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ATP Antagonizes Thrombin-Induced Signal Transduction through 12(S)-HETE and cAMP
(Public Library of Science, 2013)
In this study we have investigated the role of extracellular ATP on thrombin induced-platelet aggregation (TIPA) in washed human platelets. ATP inhibited TIPA in a dose-dependent manner and this inhibition was abolished ...
Combined Fluorescent-Chromogenic In Situ Hybridization for Identification and Laser Microdissection of Interphase Chromosomes
(Public Library of Science, 2013)
Chromosome territories constitute the most conspicuous feature of nuclear architecture, and they exhibit non-random distribution patterns in the interphase nucleus. We observed that in cell nuclei from humans with Down ...
The role of purinergic receptor A1 in neurogenesis modulation from subventricular zone
(2016-06-16)
La neurogénesis continúa en la edad adulta en regiones específicas del cerebro como la zona subgranular del hipocampo y la zona subventricular (SVZ) de los ventrículos laterales. Resultados previos de nuestro laboratorio ...
Interacción entre quinasas y moléculas apoptóticas en la muerte oligodendroglial excitotóxica
(2016-05-27)
El fenómeno de excitotoxicidad glutamatérgica supone una de las causas subyacentes de multitud de enfermedades neurodegenerativas y afecta, entre otros tipos celulares, a los oligodendrocitos. Precisamente la vulnerabilidad ...
Subclinical Depressive Symptoms and Continued Cannabis Use: Predictors of Negative Outcomes in First Episode Psychosis
(Public Library Science, 2015-04-15)
Background
Although depressive symptoms in first episode psychosis have been associated with cannabis abuse, their influence on the long-term functional course of FEP patients who abuse cannabis is unknown. The aims of ...
Pio del Rio Hortega and the discovery of the oligodendrocytes
(Frontiers Research Foundation, 2015-07-07)
Rio del Rio Hortega (1882-1945) discovered microglia and oligodendrocytes (OLGs), and after Ramon y Cajal, was the most prominent figure of the Spanish school of neurology. He began his scientific career with Nicolas ...
Neurotransmitter signaling in the pathophysiology of microglia
(Frontiers Research Foundation, 2013)
Microglial cells are the resident immune cells of the central nervous system. In the resting state, microglia are highly dynamic and control the environment by rapidly extending and retracting motile processes. Microglia ...
Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis
(Frontiers Research Foundation, 2013-01)
Microglia are the resident brain macrophages and they have been traditionally studied as orchestrators of the brain inflammatory response during infections and disease. In addition, microglia has a more benign, less explored ...
Plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis
(BioMed Central, 2013)
Background: Cognitive impairments are seen in first psychotic episode (FEP) patients. The neurobiological underpinnings that might underlie these changes remain unknown. The aim of this study is to investigate whether
Brain ...
Papel de las GTPasas de la familia rho en la señalización mediada por el receptor P2X7
(2013-09-24)
El objetivo de este proyecto es estudiar la señalización del receptor P2X7 en respuesta a ATP en macrófagos J774A.1 y en células CHO K1. Para ello, se subclonó el gen que codifica para la proteína P2X7 en el vector PMT2 ...