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Papel de las GTPasas de la familia rho en la señalización mediada por el receptor P2X7 

Iturrioz Rodríguez, Nerea (2013-09-24)
El objetivo de este proyecto es estudiar la señalización del receptor P2X7 en respuesta a ATP en macrófagos J774A.1 y en células CHO K1. Para ello, se subclonó el gen que codifica para la proteína P2X7 en el vector PMT2 ...
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Arquitectura subcelular del sistema endocannabinoide en el núcleo ventromedial del hipotálamo de ratón 

Reguero Acebal, Leire (2014-01-30)
El sistema endocannabinoide (eCB) es un complejo sistema endógeno de señalización, que participa en la modulación de la transmisión sináptica en múltiples circuitos cerebrales, incluyendo los que regulan el apetito, ingesta ...
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Interacción entre quinasas y moléculas apoptóticas en la muerte oligodendroglial excitotóxica 

Canedo Antelo, Manuel (2016-05-27)
El fenómeno de excitotoxicidad glutamatérgica supone una de las causas subyacentes de multitud de enfermedades neurodegenerativas y afecta, entre otros tipos celulares, a los oligodendrocitos. Precisamente la vulnerabilidad ...
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Differential Neuroprotective Effects of 5 '-Deoxy-5 '-Methylthioadenosine 

Moreno, Beatriz; Lopez, Iciar; Fernández-Díez, Begoña; Gottlieb, Miroslav; Matute Almau, Carlos José; Sánchez Gómez, María Victoria; Domercq García, María; Giralt, Albert; Alberch, Jordi; Collon, Kevin W.; Zhang, Helen; Parent, Jack M.; Teixido, Meritxell; Giralt, Ernest; Ceña, Valentín; Posadas, Inmaculada; Martínez-Pinilla, Eva; Villoslada, Pablo; Franco, Rafael (Public Library Science, 2014-03-05)
Background: 5'-deoxy-5'-methylthioadenosine (MTA) is an endogenous compound produced through the metabolism of polyamines. The therapeutic potential of MTA has been assayed mainly in liver diseases and, more recently, in ...
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FTY720 attenuates excitotoxicity and neuroinflammation 

Cipriani, Raffaela; Chara Ventura, Juan Carlos; Rodríguez-Antigüedad Zarranz, Alfredo; Matute Almau, Carlos José (BioMed Central, 2015-05-08)
Background: FTY720 (fingolimod, Gilenya(TM)), a structural analog of sphingosine-1-phosphate (S1P), is the first oral drug approved for treatment the relapsing-remitting form of multiple sclerosis (MS), and its efficacy ...
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From the Cajal alumni Achucarro and Rio-Hortega to the rediscovery of never-resting microglia 

Tremblay, Marie-Ève; Lecours, Cynthia; Samson, Louis; Sánchez Zafra, Víctor; Sierra Saavedra, Amanda (Frontiers Research Foundation, 2015-04-14)
Under the guidance of Ramon y Cajal, a plethora of students flourished and began to apply his silver impregnation methods to study brain cells other than neurons: the neuroglia. In the first decades of the twentieth century, ...
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Effects of FTY720 on brain neurogenic niches in vitro and after kainic acid-induced injury 

Cipriani, Raffaela; Chara Ventura, Juan Carlos; Rodríguez-Antigüedad Zarranz, Alfredo; Matute Almau, Carlos José (Biomed Central, 2017-07-24)
Background: FTY720 (fingolimod, Gilenya (TM)) is an oral, blood-brain barrier (BBB)-passing drug approved as immunomodulatory treatment for relapsing-remitting form of the multiple sclerosis (MS). In addition, FTY720 exerts ...
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Synaptic plasticity and spatial working memory are impaired in the CD mouse model of Williams-Beuren syndrome 

Borralleras, Cristina; Mato, Susana; Amédée, Thierry; Matute Almau, Carlos José; Mulle, Christophe; Pérez-Jurado, Luis A.; Campuzano, Victoria (null, 2016)
Mice heterozygous for a complete deletion (CD) equivalent to the most common deletion found in individuals with Williams-Beuren syndrome (WBS) recapitulate relevant features of the neurocognitive phenotype, such as ...
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Organotypic Cultures as a Model to Study Adult Neurogenesis in CNS Disorders 

Cavaliere, Fabio; Benito-Muñoz, Monica; Matute Almau, Carlos José (null, 2016)
Neural regeneration resides in certain specific regions of adult CNS. Adult neurogenesis occurs throughout life, especially from the subgranular zone of hippocampus and the subventricular zone, and can be modulated in ...
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ATP Antagonizes Thrombin-Induced Signal Transduction through 12(S)-HETE and cAMP 

Burzaco Galán, Jaione; Conde Fernández, Manuel; Parada, Luis A.; Zugaza Gurruchaga, José Luis; Dehaye, Jean-Paul; Marino Sánchez, Aida Luisa (Public Library of Science, 2013)
In this study we have investigated the role of extracellular ATP on thrombin induced-platelet aggregation (TIPA) in washed human platelets. ATP inhibited TIPA in a dose-dependent manner and this inhibition was abolished ...
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