dc.contributor.author | Ruiz, Jonatan R. | es |
dc.contributor.author | Labayen Goñi, Idoya | es |
dc.contributor.author | Ortega, Francisco B. | es |
dc.contributor.author | Moreno, Luis A | es |
dc.contributor.author | González Lamuño, Domingo | es |
dc.contributor.author | Martí, Amelia | es |
dc.contributor.author | Nova, Esther | es |
dc.contributor.author | García Fuentes, Miguel | es |
dc.contributor.author | Redondo Figuero, Carlos | es |
dc.contributor.author | Martínez, Alfredo | es |
dc.contributor.author | Sjöström, Michael | es |
dc.contributor.author | Castillo, Manuel J | es |
dc.contributor.author | AVENA Study Group | es |
dc.date.accessioned | 2011-03-29T05:25:14Z | |
dc.date.available | 2011-03-29T05:25:14Z | |
dc.date.issued | 2008-11-10 | es |
dc.identifier.citation | BMC Medical Genetics 9(98) : (2008) | es |
dc.identifier.issn | 1471-2350 | es |
dc.identifier.uri | http://hdl.handle.net/10810/2209 | |
dc.description | Es reproducción del documento publicado en http://dx.doi.org/10.1186/1471-2350-9-98 | es |
dc.description.abstract | Background: There is increasing evidence indicating that genes involved in certain metabolic processes of cardiovascular diseases may be of particular influence in people with low body weight at birth. We examined whether the apolipoprotein (APO) E, APOC3 and the peroxisome proliferator-activated receptor-gamma-2 (PPAR gamma 2) polymorphisms influence the association between low birth weight and blood lipid levels in healthy adolescents aged 13-18.5 years.
Methods: A cross-sectional study of 502 Spanish adolescents born at term was conducted. Total (TC) and high density lipoprotein cholesterol (HDLc), triglycerides (TG), apolipoprotein (apo) A and B, and lipoprotein(a) [ Lp(a)] were measured. Low density lipoprotein cholesterol (LDLc), TC-HDLc, TC/HDLc and apoB/apoA were calculated. Results: Low birth weight was associated with higher levels of TC, LDLc, apoB, Lp(a), TC-HDLc, TC/HDLc and apoB/apoA in males with the APOE epsilon 3 epsilon 4 genotype, whereas in females, it was associated with lower HDLc and higher TG levels. In males with the APOC3 S1/S2 genotype, low birth weight was associated with lower apoA and higher Lp(a), yet this association was not observed in females. There were no associations between low birth weight and blood lipids in any of the PPAR gamma 2 genotypes.
Conclusion: The results indicate that low birth weight has a deleterious influence on lipid profile particularly in adolescents with the APOE epsilon 3/epsilon 4 genotype. These findings suggest that intrauterine environment interact with the genetic background affecting the lipid profile in later life. | es |
dc.description.sponsorship | Instituto de Salud Carlos III (FIS PI021830), the Spanish Ministry of Health, FEDER-FSE funds FIS n 00/0015, CSD grants 05/UPB32/0, 109/UPB31/03 and 13/UPB20/04, Ministerio de Educación (AP-2004-2745; EX2007-1124) | es |
dc.language.iso | eng | es |
dc.publisher | BioMed Central | es |
dc.relation | info:eu-repo/grantAgreement/MCYT/AP2004-2745 | |
dc.relation | info:eu-repo/grantAgreement/MCYT/EX2007-1124 | |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | cardiovascular disease risk | es |
dc.subject | body fat composition | es |
dc.subject | PRO12ALA polymorphism | es |
dc.subject | PPAR gamma 2 gene | es |
dc.subject | metabolism interact | es |
dc.subject | insulin sensitivity | es |
dc.subject | physical fitness | es |
dc.subject | reference values | es |
dc.subject | sex differences | es |
dc.title | Birth weight and blood lipid levels in Spanish adolescents: Influence of selected APOE, APOC3 and PPARgamma2 gene polymorphisms. The AVENA Study | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | (c) 2008 Ruiz et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | es |
dc.departamentoes | Farmacia y ciencias de los alimentos | es_ES |
dc.departamentoeu | Farmazia eta elikagaien zientziak | es_ES |
dc.subject.categoria | GENETICS AND HEREDITY | |