Browsing Artículos by Author "Ugedo, Luisa"
Now showing items 1-14 of 14
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6-Hydroxydopamine lesion and levodopa treatment modif y the effect of buspirone in the substantia nigra pars reticulata
Vegas Suárez, Sergio ; Pisanò, Clarissa Anna; Requejo Rodríguez, Catalina ; Bengoetxea Odriozola, Harkaitz; Lafuente Sánchez, José Vicente ; Morari, Michele; Miguelez Palomo, Cristina; Ugedo Urruela, Luisa (Wiley, 2020-09)Background and Purpose l-DOPA-induced dyskinesia (LID) is considered a major complication in the treatment of Parkinson's disease (PD). Buspirone (5-HT(1A)partial agonist) have shown promising results in the treatment of ... -
Activation of Extracellular Signal-Regulated Kinases (ERK 1/2) in the Locus Coeruleus Contributes to Pain-Related Anxiety in Arthritic Male Rats
Borges, Gisela; Miguélez Palomo, Cristina; Neto, Fani; Mico, Juan Antonio; Ugedo Urruela, Luisa; Berrocoso, Esther (Oxford University Press, 2017-06)Background: There is increasing evidence suggesting that the Locus Coeruleus plays a role in pain-related anxiety. Indeed, we previously found that prolonged arthritis produces anxiety-like behavior in rats, along with ... -
Acute L-DOPA administration reverses changes in firing pattern and low frequency oscillatory activity in the entopeduncular nucleus from long term L-DOPA treated 6-OHDA-lesioned rats
Aristieta Arbelaiz, Asier; Ruiz Ortega, José Ángel; Morera Herreras, Teresa; Miguélez Palomo, Cristina; Ugedo Urruela, Luisa (Elsevier, 2019-12)The pathophysiology of Parkinson's disease (PD) and L-DOPA-induced dyskinesia (LID) is associated with aberrant neuronal activity and abnormal high levels of oscillatory activity and synchronization in several basal ganglia ... -
Buspirone anti-dyskinetic effect is correlated with temporal normalization of dysregulated striatal DRD1 signalling in L-DOPA-treated rats
Azkona Mendoza, Garikoitz ; Sagarduy Crespo, Ainhoa ; Aristieta Arbelaiz, Asier; Vazquez, Nerea; Zubillaga, Veronica; Ruiz Ortega, José Ángel; Pérez Navarro, Esther; Ugedo Urruela, Luisa; Sánchez Pernaute, Rosario (Elsevier, 2014-04)Dopamine replacement with l-DOPA is the most effective therapy in Parkinson's disease. However, with chronic treatment, half of the patients develop an abnormal motor response including dyskinesias. The specific molecular ... -
Changes in Day/Night Activity in the 6-OHDA-Induced Experimental Model of Parkinson’s Disease: Exploring Prodromal Biomarkers
Requejo Rodríguez, Catalina ; López de Ipiña Peña, Miren Karmele; Ruiz Ortega, José Ángel; Fernández Gómez de Segura, Elsa; Calvo Salomón, Pilar María; Morera Herreras, Teresa; Miguélez Palomo, Cristina; Cardona Grifoll, Laura; Cepeda Berenguer, Hodei; Ugedo Urruela, Luisa; Lafuente Sánchez, José Vicente (Frontiers Media, 2020-10-14)The search for experimental models mimicking an early stage of Parkinson's disease (PD) before motor manifestations is fundamental in order to explore early signs and get a better prognosis. Interestingly, our previous ... -
Dopaminergic Denervation Impairs Cortical Motor and Associative/Limbic Information Processing Through the Basal Ganglia and its Modulation by the CB1 Receptor
Antonazzo Soler, Mario ; Gómez Urquijo, Sonia María ; Ugedo Urruela, Luisa; Morera Herreras, Teresa (Academic Press, 2021-01)The basal ganglia (BG) are involved in cognitive/motivational functions in addition to movement control. Thus, BG segregated circuits, the sensorimotor (SM) and medial prefrontal (mPF) circuits, process different functional ... -
Effects of adult enriched environment on cognition, hippocampal- prefrontal plasticity and NMDAR subunit expression in MK-801- induced schizophrenia model
Murueta-Goyena Larrañaga, Ane; Morera Herreras, Teresa; Miguélez Palomo, Cristina; Gutiérrez Ceballos, Amaia; Ugedo Urruela, Luisa; Lafuente Sánchez, José Vicente ; Bengoetxea Odriozola, Harkaitz (Elsevier, 2019-05-01)Schizophrenia is a mental disorder characterized by psychosis, negative symptoms and cognitive impairment. Cognitive deficits are enduring and represent the most disabling symptom but are currently poorly treated. N-methyl ... -
Fast and Efficient Neural Conversion of Human Hematopoietic Cells
Castaño, Julio; Menéndez, Pablo; Bruzos Cidón, Cristina ; Straccia, Marco; Sousa, Amaia; Zabaleta, Lorea; Vázquez, Nerea; Zubiarrain, Amaia; Sonntag, Kai-Christian; Ugedo Urruela, Luisa; Carvajal Vergara, Xonia; Canals, Josep Maria; Torrecilla Sesma, María ; Sánchez-Pernaute, Rosario; Giorgetti, Alessandra (Cell Press, 2014-12-09)Neurons obtained directly from human somatic cells hold great promise for disease modeling and drug screening. Available protocols rely on overexpression of transcription factors using integrative vectors and are often ... -
Impairment of Serotonergic Transmission by the Antiparkinsonian Drug L-DOPA: Mechanisms and Clinical Implications
Miguélez Palomo, Cristina; Benazzouz, Abdelhamid; Ugedo Urruela, Luisa; De Deurwaerdère, Philippe (Frontiers Media, 2017-09-12)The link between the anti-Parkinsonian drug L-3,4-dihydroxyphenylalanine (L-DOPA) and the serotonergic (5-HT) system has been long established and has received increased attention during the last decade. Most studies have ... -
Increased antiparkinson efficacy of the combined administration of VEGF- and GDNF-loaded nanospheres in a partial lesion model of Parkinson's disease
Herrán Martínez, Enara; Requejo Rodríguez, Catalina ; Ruiz Ortega, José Ángel; Aristieta Arbelaiz, Asier; Igartua Olaechea, Manuela ; Bengoetxea Odriozola, Harkaitz; Ugedo Urruela, Luisa; Pedraz Muñoz, José Luis ; Lafuente Sánchez, José Vicente ; Hernández Martín, Rosa María (Dove Medical Press, 2014)Current research efforts are focused on the application of growth factors, such as glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), as neuroregenerative approaches that will ... -
Interaction between the 5-HT system and the basal ganglia: functional implication and therapeutic perspective in Parkinson's disease
Miguélez Palomo, Cristina; Morera Herreras, Teresa; Torrecilla Sesma, María ; Ruiz Ortega, José Ángel; Ugedo Urruela, Luisa (Frontiers Research Foundation, 2014-03-17)The neurotransmitter serotonin (5-HT) has a multifaceted function in the modulation of information processing through the activation of multiple receptor families, including G-protein-coupled receptor subtypes (5-HT1, ... -
The Effect of 5-HT1A Receptor Agonists on the Entopeduncular Nucleus is Modified in 6-Hydroxydopamine-Lesioned Rats
Vegas Suárez, Sergio ; Aristieta Arbelaiz, Asier; Requejo Rodríguez, Catalina ; Bengoetxea Odriozola, Harkaitz; Lafuente Sánchez, José Vicente ; Miguélez Palomo, Cristina; Ugedo Urruela, Luisa (Wiley, 2021-06)Background and Purpose l-DOPA prolonged treatment leads to disabling motor complications as dyskinesia that could be decreased by drugs acting on 5-HT1A receptors. Since the internal segment of the globus pallidus, homologous ... -
The locus coeruleus Is Directly Implicated in L-DOPA-Induced Dyskinesia in Parkinsonian Rats: An Electrophysiological and Behavioural Study
Miguélez Palomo, Cristina; Aristieta Arbelaiz, Asier; Cenci, María Angela; Ugedo Urruela, Luisa (Public Library Science, 2011-09)Despite being the most effective treatment for Parkinson's disease, L-DOPA causes a development of dyskinetic movements in the majority of treated patients. L-DOPA-induced dyskinesia is attributed to a dysregulated dopamine ... -
The Role of the Subthalamic Nucleus in L-DOPA Induced Dyskinesia in 6-Hydroxydopamine Lesioned Rats
Aristieta Arbelaiz, Asier; Azkona Mendoza, Garikoitz ; Sagarduy Crespo, Ainhoa ; Miguélez Palomo, Cristina; Ruiz Ortega, José Ángel; Sánchez Pernaute, Rosario; Ugedo Urruela, Luisa (Public Library of Science, 2012-08-06)L-DOPA is the most effective treatment for Parkinson's disease (PD), but prolonged use leads to disabling motor complications including dyskinesia. Strong evidence supports a role of the subthalamic nucleus (STN) in the ...