BackBrowsing Artículos by Author "Etxaniz, Asier"
Now showing items 1-10 of 10
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Adenylate Cyclase Toxin promotes bacterial internalisation into non phagocytic cells
; ; ; ; González Bullón, David
; Arluzea de Jauregizar, Jon Andoni ; Goñi Urcelay, Félix María ; Arechaga Martínez, Juan Miguel ; (Nature Publishing Group, 2015-09-08)
Bordetella pertussis causes whooping cough, a respiratory infectious disease that is the fifth largest cause of vaccine-preventable death in infants. Though historically considered an extracellular pathogen, this bacterium ... -
Autophagy protein LC3C binding to phospholipid and interaction with lipid membranes
; ; ; ; ; ; Montes Burgos, Lidia Ruth; ; Goñi Urcelay, Félix María ; Alonso Izquierdo, Alicia (Elsevier, 2022-05-23)
Autophagy is a process in which parts of the eukaryotic cell are selectively degraded in the lysosome. The materials to be catabolized are first surrounded by a double-membrane structure, the autophagosome. Autophagosome ... -
Effect of ATG12–ATG5-ATG16L1 autophagy E3-like complex on the ability of LC3/GABARAP proteins to induce vesicle tethering and fusion
; ; ; ; ; ; ; ; Montes Burgos, Lidia Ruth; Goñi Urcelay, Félix María ; Alonso Izquierdo, Alicia (Springer, 2023-02)
In macroautophagy, the autophagosome (AP) engulfs portions of cytoplasm to allow their lysosomal degradation. AP formation in humans requires the concerted action of the ATG12 and LC3/GABARAP conjugation systems. The ... -
Effects of a N-Maleimide-derivatized Phosphatidylethanolamine on the Architecture and Properties of Lipid Bilayers
; ; De la Arada Echevarría, Igor; ; ; Goñi Urcelay, Félix María ; Alonso Izquierdo, Alicia ; Montes Burgos, Lidia Ruth (MDPI, 2023-11-21)
<i>N</i>-maleimide-derivatized phospholipids are often used to facilitate protein anchoring to membranes. In autophagy studies, this is applied to the covalent binding of Atg8, an autophagy protein, to a phosphatidylethanolamine ... -
Irreversible versus repairable membrane poration: differences in permeabilization elicited by Bordetella Adenylate Cyclase Toxin and its hemolysin domain in macrophages
; González Bullón, David; ; ; (FEBS Press, 2019-10-24)
Rapid plasma membrane repair in response to pore-forming toxins is crucial for cell survival, but the molecular mechanisms employed by eukaryotic nucleated cells to maintain membrane integrity and the specificities of such ... -
LC3 subfamily in cardiolipin-mediated mitophagy: a comparison of the LC3A, LC3B and LC3C homologs
; ; ; ; Hervás Hidalgo, Javier; Montes Burgos, Lidia Ruth ; Goñi Urcelay, Félix María ; Alonso Izquierdo, Alicia (Taylor & Francis, 2022-12)
Externalization of the phospholipid cardiolipin (CL) to the outer mitochondrial membrane has been proposed to act as a mitophagy trigger. CL would act as a signal for binding the LC3 macroauto-phagy/autophagy proteins. As ... -
Lipids in Mitochondrial Macroautophagy: Phase Behavior of Bilayers Containing Cardiolipin and Ceramide
; ; ; ; ; Montes Burgos, Lidia Ruth; Goñi Urcelay, Félix María ; Alonso Izquierdo, Alicia (MDPI, 2023-03-07)
Cardiolipin (CL) is a key lipid for damaged mitochondrial recognition by the LC3/GABARAP human autophagy proteins. The role of ceramide (Cer) in this process is unclear, but CL and Cer have been proposed to coexist in ... -
Membrane Repair Mechanisms against Permeabilization by Pore-Forming Toxins
; González Bullón, David; ; (MDPI, 2018-06-09)
Permeabilization of the plasma membrane represents an important threat for any cell, since it compromises its viability by disrupting cell homeostasis. Numerous pathogenic bacteria produce pore-forming toxins that break ... -
Phase behaviour of C18-N-acyl sphingolipids, the prevalent species in human brain.
; ; Alonso Izquierdo, Alicia; Goñi Urcelay, Félix María (Elsevier, 2022-11)
Lipidomic analysis of the N-acyl components of sphingolipids in different mammalian tissues had revealed that brain tissue differed from all the other samples in that SM contained mainly C18:0 and C24:1N-acyl chains, and ... -
Understanding the Mechanism of Translocation of Adenylate Cyclase Toxin across Biological Membranes
; ; González Bullón, David; Belloso Uribe, Kepa; (MDPI, 2017-09-21)
Adenylate cyclase toxin (ACT) is one of the principal virulence factors secreted by the whooping cough causative bacterium Bordetella pertussis, and it has a critical role in colonization of the respiratory tract and ...