BackExaminar Artículos por departamento (eus.) "Neurozientziak"
Now showing items 41-60 of 345
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Association of Notch-1, osteopontin and stem-like cells in ENU-glioma malignant process
Bulnes Sesma, Susana; Bermúdez, Garazi; Lafuente Sánchez, José Vicente
(Impact Journals LLC, 2018-07-31)
Notch-1 and osteopontin (OPN) mediate angiogenesis and glioma stem-like cell (GSLC) maintenance. However, the relationship between these molecules and GSLCs during the development of glioma is unknown. We investigate the ... -
Association of retinal neurodegeneration with the progression of cognitive decline in Parkinson’s disease
(Nature, 2024-01)Retinal thickness may serve as a biomarker in Parkinson’s disease (PD). In this prospective longitudinal study, we aimed to determine if PD patients present accelerated thinning rate in the parafoveal ganglion cell-inner ... -
Astrocyte dystrophy in ageing brain parallels impaired synaptic plasticity
(2021-03)Little is known about age-dependent changes in structure and function of astrocytes and of the impact of these on the cognitive decline in the senescent brain. The prevalent view on the age-dependent increase in reactive ... -
Astrocytes in Alzheimer’s Disease: Pathological Significance and Molecular Pathways
Preman, Pranav; Alfonso Triguero, Maria; Alberdi Alfonso, Elena María; Verkhratsky, Alexei; Arranz Mendiguren, Amaia (MDPI, 2021-03-04)
Astrocytes perform a wide variety of essential functions defining normal operation of the nervous system and are active contributors to the pathogenesis of neurodegenerative disorders such as Alzheimer’s among others. ... -
Astrocytic Atrophy as a Pathological Feature of Parkinson's Disease with LRRK2 Mutation
Ramos González, Paula; Mato Santos, Susana; Chara Ventura, Juan Carlos; Verkhratsky, Alexei; ; Cavaliere, Fabio (Springer, 2021-03-30)
The principal hallmark of Parkinson's disease (PD) is the selective neurodegeneration of dopaminergic neurones. Mounting evidence suggests that astrocytes may contribute to dopaminergic neurodegeneration through decreased ... -
Attachment anxiety as mediator of the relationship between childhood trauma and personality dysfunction in borderline personality disorder
Erkoreka González, Leire; Zamalloa Díaz, Iker ; ; ; ; ; ; ; González Torres, Miguel Ángel (Wiley, 2022-03)
Insecure attachment has been described as mediating the relationship between childhood trauma and dysfunctional personality traits in different mental disorders. Despite the role insecure attachment and childhood trauma ... -
Autonomic dysfunction is associated with neuropsychological and neuropsychiatric impairment in patients with Lewy body diseases
(Springer-Verlag GmbH Germany, 2020-03-13)Objective: This study aimed to analyze the association of autonomic dysfunction with cognition, depression, apathy, and fatigue in Lewy body disease (LBD). Methods: We included 61 patients [49 with idiopathic Parkinson’s ... -
Autophagic Marker MAP1LC3B Expression Levels Are Associated with Carotid Atherosclerosis Symptomatology
(Public Library Science, 2014-12-12)Objectives: The mechanism by which atheroma plaque becomes unstable is not completely understood to date but analysis of differentially expressed genes in stable versus unstable plaques may provide clues. This will be ... -
BASP1 labels neural stem cells in the neurogenic niches of mammalian brain
(Springer Nature, 2021-03-10)The mechanisms responsible for determining neural stem cell fate are numerous and complex. To begin to identify the specific components involved in these processes, we generated several mouse neural stem cell (NSC) antibodies ... -
Bipolar disorder comorbid with alcohol use disorder: Focus on neurocognitive correlates
Balanzá Martínez, Vicent; Crespo Facorro, Benedicto; González Pinto Arrillaga, Ana María; (Frontiers Research Foundation, 2015-04-07)
Bipolar disorder (BD) and alcohol use disorders (AUDs) are usually comorbid, and both have been associated with significant neurocognitive impairment. Patients with the BD-AUD comorbidity (dual diagnosis) may have more ... -
Birth Weight, Working Memory and Epigenetic Signatures in IGF2 and Related Genes: A MZ Twin Study
González Pinto Arrillaga, Ana María; Córdova-Palomera, Aldo; Alemany, Silvia; Fatjó-Vilas, Mar; Goldberg, Ximena; Leza, Juan Carlos; Nenadic, Igor; Fañanás, Lourdes (Public Library Science, 2014-08-29)
Neurodevelopmental disruptions caused by obstetric complications play a role in the etiology of several phenotypes associated with neuropsychiatric diseases and cognitive dysfunctions. Importantly, it has been noticed that ... -
Blood miRNA expression pattern is a possible risk marker for natalizumab-associated progressive multifocal leukoencephalopathy in multiple sclerosis patients
(Sage, 2014-05-22)Background: Natalizumab has shown its efficacy in reducing multiple sclerosis (MS) relapses and progression of disability; however, it has been associated with an increased risk of developing progressive multifocal ... -
Brain fog of post-COVID-19 condition and Chronic Fatigue Syndrome, same medical disorder?
; ; ; ; ; ; ; ; Lafuente Sánchez, José Vicente; ; ; ; ; ; (BMC, 2022-12)
Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is characterized by persistent physical and mental fatigue. The post-COVID-19 condition patients refer physical fatigue and cognitive impairment ... -
Brain White Matter Correlates of Creativity in Schizophrenia: A Diffusion Tensor Imaging Study
; ; ; ; Sánchez Gómez, Pedro María; ; ; ; (Frontiers Media, 2020-06)
The relationship between creativity and psychopathology has been a controversial research topic for decades. Specifically, it has been shown that people with schizophrenia have an impairment in creative performance. However, ... -
Brca1 is expressed in human microglia and is dysregulated in human and animal model of ALS
(Biomed Central, 2015-08-01)Background: There is growing evidence that microglia are key players in the pathological process of amyotrophic lateral sclerosis (ALS). It is suggested that microglia have a dual role in motoneurone degeneration through ... -
Calcium Mechanisms in Limb-Girdle Muscular Dystrophy with CAPN3 Mutations
Lasa Elgarresta, Jaione; Mosqueira Martín, Laura; Naldaiz Gastesi, Neia; Sáenz Peña, Amets; López de Munain Arregui, Adolfo José; Vallejo Illarramendi, Ainara (MDPI, 2019-09-02)
Limb-girdle muscular dystrophy recessive 1 (LGMDR1), previously known as LGMD2A, is a rare disease caused by mutations in the CAPN3 gene. It is characterized by progressive weakness of shoulder, pelvic, and proximal limb ... -
Can an Experimental White Noise Task Assess Psychosis Vulnerability in Adult Healthy Controls?
González de Artaza Lavesa, Maider; Catalán Alcántara, Ana; Angosto, Virxinia; Valverde, Cristina; Bilbao, Amaia; Van Os, Jim; González Torres, Miguel Ángel (Public Library Science, 2018-02-15)
Background This is an extension of a paper published earlier. We investigated the association between the tendency to detect speech illusion in random noise and levels of positive schizotypy in a sample of 185 adult ... -
Cannabidiol Administration Prevents Hypoxia-Ischemia-Induced Hypomyelination in Newborn Rats
; ; ; ; ; Achicallende Urcaregui, Svein; Elezgarai Gabantxo, Izaskun ; Grandes Moreno, Pedro Rolando ; ; ; (Frontiers Media, 2019-09-26)
Neonatal hypoxia-ischemia (HI) is a risk factor for myelination disturbances, a key factor for cerebral palsy. Cannabidiol (CBD) protects neurons and glial cells after HI insult in newborn animals. We hereby aimed to study ... -
Cannabinoid CB1 receptor gene inactivation in oligodendrocyte precursors disrupts oligodendrogenesis and myelination in mice
; ; ; ; ; ; ; ; Mato Santos, Susana; ; ; ; (SpringerNature, 2022)
[EN] Cannabinoids are known to modulate oligodendrogenesis and developmental CNS myelination. However, the cell-autonomous action of these compounds on oligodendroglial cells in vivo, and the molecular mechanisms underlying ... -
Cannabinoid CB2 Receptors Modulate Microglia Function and Amyloid Dynamics in a Mouse Model of Alzheimer's Disease
; ; Terradillos Irastorza, Itziar; ; ; ; ; ; ; ; Elezgarai Gabantxo, Izaskun ; ; ; ; Grandes Moreno, Pedro Rolando ; ; (Frontiers Media, 2022-04)
The distribution and roles of the cannabinoid CB2 receptor in the CNS are still a matter of debate. Recent data suggest that, in addition to its presence in microglial cells, the CB2 receptor may be also expressed at low ...