BackExaminar Artículos por departamento (eus.) "Genetika,antropologia fisikoa eta animalien fisiologia"
Now showing items 21-40 of 236
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A systematic review and meta-analysis of MTHFR polymorphisms in methotrexate toxicity prediction in pediatric acute lymphoblastic leukemia
López López, Elixabet
; ; Ballesteros Rodríguez, Francisco Javier ; García-Orad Carles, África (Springer, 2013-10-23)
Methotrexate (MTX) is an important component of therapy used to treat childhood acute lymphoblastic leukemia (ALL). Two single-nucleotide polymorphisms (SNPs) in the methylenetetrahydrofolate reductase (MTHFR) gene, C677T ... -
A Systematic Two-Sample Mendelian Randomization Analysis Identifies Shared Genetic Origin of Endometriosis and Associated Phenotypes
Garitazelaia González, Aiara; Rueda Martínez, Aintzane; Arauzo, Rebeca; De Miguel, Jokin; Cilleros Portet, Ariadna; Marí Alemany, Sergi; Bilbao Catalá, José Ramón ; Fernández Jiménez, Nora ; García Santisteban, Iraia (MDPI, 2021-01-03)
Endometriosis, one of the most common gynecological disorders, is a complex disease characterized by the growth of endometrial-like tissue in extra-uterine locations and is a cause of pelvic pain and infertility. Evidence ... -
A TaqMan real-time PCR based assay targeting plaice (Pleuronectes platessa L.) DNA to detect predation by the brown shrimp (Crangon crangon L.) and the shore crab (Carcinus maenas L.)—Assay development and validation
(Elsevier, 2010-07-14)We describe a protocol for the preservation, extraction, and detection of plaice (Pleuronectes platessa) DNA from the stomach contents of the brown shrimp, Crangon crangon and the shore crab, Carcinus maenas. These two ... -
A Two-Sample Mendelian Randomization Analysis Investigates Associations Between Gut Microbiota and Celiac Disease
García Santisteban, Iraia; Cilleros Portet, Ariadna ; Moyua Ormazabal, Elisabet; Kurilshikov, Alexander; Zhernakova, Alexandra; García Etxebarria, Koldo; Fernández Jiménez, Nora ; Bilbao Catalá, José Ramón (MDPI, 2020-05-14)
Celiac disease (CeD) is a complex immune-mediated inflammatory condition triggered by the ingestion of gluten in genetically predisposed individuals. Literature suggests that alterations in gut microbiota composition and ... -
A Universal Antigen-Ranking Method to Design Personalized Vaccines Targeting Neoantigens against Melanoma
Malaina Celada, Iker; Martínez Fernández, Luis ; ; Alonso Alegre, Santos ; Boyano López, María Dolores ; Asumendi Mallea, Aintzane ; ; ; ; (MDPI, 2023-01-05)
Background: The main purpose of this article is to introduce a universal mathematics-aided vaccine design method against malignant melanoma based on neoantigens. The universal method can be adapted to the mutanome of each ... -
Accuracy in Copy Number Calling by qPCR and PRT : A Matter of DNA
; ; ; ; Irastorza Terradillos, Iñaki Xarles; Castaño González, Luis Antonio ; ; Bilbao Catalá, José Ramón (Public Library of Science, 2011-12-13)
The possible implication of copy number variation (CNV) in the genetic susceptibility to human disease needs to be assessed using robust methods that can be applied at a population scale. In this report, we analyze the ... -
Acute toxicity of zinc and arsenic to the warmwater aquatic oligochaete Branchiura sowerbyi as compared to its coldwater counterpart Tubifex tubifex (Annelida, Clitellata)
; Méndez Fernández, Leire; Martínez Madrid, Maite ; ; (Springer, 2016-07-12)
Purpose This study aimed at evaluating the acute effects of arsenic and zinc to the warmwater aquatic oligochaete Branchiura sowerbyi. Relative sensitivity with the coldwater species Tubifex tubifex was compared. Implications ... -
Allometric size-scaling of biometric growth parameters and metabolic and excretion rates. A comparative study of intertidal and subtidal populations of mussels (Mytilus galloprovincialis)
(Springer, 2016-01-27)Allometric relationships between biometric parameters (i.e., soft body and shell weights and shell organic content vs. shell length) as well as for routine and standard metabolic and ammonia excretion rates related to flesh ... -
AmelHap: Leveraging drone whole-genome sequence data to create a honey bee HapMap
(Nature, 2023-04)Honey bee, Apis mellifera, drones are typically haploid, developing from an unfertilized egg, inheriting only their queen’s alleles and none from the many drones she mated with. Thus the ordered combination or ‘phase’ of ... -
Amyloid β1–42 Oligomers Induce Galectin–1S8 O–GlcNAcylation Leading to Microglia Migration
; ; ; Zugaza Gurruchaga, José Luis (MDPI, 2023-07-17)
Protein O–GlcNAcylation has been associated with neurodegenerative diseases such as Alzheimer’s disease (AD). The O–GlcNAcylation of the Amyloid Precursor Protein (APP) regulates both the trafficking and the processing of ... -
An E2F7-Dependent Transcriptional Program Modulates DNA Damage Repair And Genomic Stability
Michelena Sánchez, Jone; Apraiz García, Aintzane ; Vallejo Rodríguez, Jon ; García Santisteban, Iraia ; Fullaondo Elordui-Zapaterieche, Asier ; ; ; Zubiaga Elordieta, Ana María (Oxford University Press, 2018-05-18)
The cellular response to DNA damage is essential for maintaining the integrity of the genome. Recent evidence has identified E2F7 as a key player in DNA damage-dependent transcriptional regulation of cell-cycle genes. ... -
Ancient DNA from Hunter-Gatherer and Farmer Groups from Northern Spain Supports a Random Dispersion Model for the Neolithic Expansion into Europe
Hervella Afonso, Montserrat; Izagirre Arribalzaga, Neskuts ; Alonso Alegre, Santos ; Fregel, Rosa; Alonso, Antonio; Cabrera, Vicente M.; De la Rúa Vaca, Concepción (Public Library of Science, 2012-04-25)
Background/Principal Findings: The phenomenon of Neolithisation refers to the transition of prehistoric populations from a hunter-gatherer to an agro-pastoralist lifestyle. Traditionally, the spread of an agro-pastoralist ... -
Ancient DNA from South-East Europe Reveals Different Events during Early and Middle Neolithic Influencing the European Genetic Heritage
Hervella Afonso, Montserrat; Rotea, Mihai; Izagirre Arribalzaga, Neskuts ; Constantinescu, Mihai; Alonso Alegre, Santos ; Ioana, Mihai; Lazăr, Cătălin; Ridiche, Florin; Soficaru, Andrei Dorian; Netea, Mihai G.; De la Rúa Vaca, Concepción (Public Library Science, 2015-06-08)
The importance of the process of Neolithization for the genetic make-up of European populations has been hotly debated, with shifting hypotheses from a demic diffusion (DD) to a cultural diffusion (CD) model. In this regard, ... -
Association among obesity-related anthropometric phenotypes: analyzing genetic and environmental contribution
; Rebato Ochoa, Esther Matilde (Wayne State University Press, 2012-04-01)
Obesity has become a public-health and policy problem in many parts of the world. Epidemiological and population studies in this field are usually based on different anthropometric measures; however, common genetic and ... -
Association of Current and Former Smoking With Body Mass Index: a Study of Smoking Discordant Twin Pairs From 21 Twin Cohorts
Piirtola, Maarit; Jelenkovic Moreno, Aline; Latvala, Antti; Sund, Reijo; Honda, Chika; Inui, Fujio; Watanabe, Mikio; Tomizawa, Rie; Iwatani, Yoshinori; Ordoñana Martín, Juan Ramón; Sánchez Romera, Juan Francisco; Colodro Conde, Lucia; Tarnoki, Adam D.; Tarnoki, David L.; Martin, Nicholas G.; Montgomery, Grant W.; Medland, Sarah E.; Rasmussen, Finn; Tynelius, Per; Tan, Qihua; Zhang, Dongfeng; Pang, Zengchang; Rebato Ochoa, Esther Matilde; Stazi, Maria A.; Fagnani, Corrado; Brescianini, Sonia; Busjahn, Andreas; Harris, Jennifer R.; Brandt, Ingunn; Nilsen, Thomas Sevenius; Cutler, Tessa L.; Hopper, John L.; Corley, Robin P.; Huibregtse, Brooke M.; Sung, Joohon; Kim, Jina; Lee, Jooyeon; Lee, Sooji; Gatz, Margaret; Butler, David A.; Franz, Carol E.; Kremen, William S.; Lyons, Michael J.; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Aslan, Anna K. Dahl; Oncel, Sevgi Y.; Aliev, Fazil; Derom, Catherine A.; Vlietinck, Robert F.; Loos, Ruth J. F.; Silberg, Judy L.; Maes, Hermine H.; Boomsma, Dorret I.; Sorensen, Thorkild I. A.; Korhonen, Tellervo; Kaprio, Jaakko; Silventoinen, Karri (Public Library Science, 2018-07-12)
Background Smokers tend to weigh less than never smokers, while successful quitting leads to an increase in body weight. Because smokers and non-smokers may differ in genetic and environmental family background, we ... -
Association of height and pubertal timing with lipoprotein subclass profile: exploring the role of genetic and environmental effects
(Wiley, 2013-05-04)Objectives: Little is known about the relationship between growth and lipoprotein profile. We aimed to analyze common genetic and environmental factors in the association of height from late childhood to adulthood and ... -
Association of TYR SNP rs1042602 with Melanoma Risk and Prognosis
Sevilla Mambrilla, Arrate; ; ; Izagirre Arribalzaga, Neskuts ; ; ; ; ; ; ; ; Asumendi Mallea, Aintzane ; Boyano López, María Dolores ; Alonso Alegre, Santos (MDPI, 2022-12-01)
Cutaneous melanoma is the most aggressive of skin tumors. In order to discover new biomarkers that could help us improve prognostic prediction in melanoma patients, we have searched for germline DNA variants associated ... -
Authoritative subspecies diagnosis tool for European honey bees based on ancestryinformative SNPs
Momeni, Jamal; Parejo Feuz, Melanie; Nielsen, Rasmus O.; Langa Arranz, Jorge Eliseo; Montes Asperilla, Iratxe ; Papoutsis, Laetitia; Farajzadeh, Leila; Bendixen, Christian; Căuia, Eliza; Charrière, Jean-Daniel; Coffey, Mary F.; Costa, Cecilia; Dall’Olio, Raffaele; De la Rúa, Pilar; Drazic, M.Maja; Filipi, Janja; Galea, Thomas; Golubovski, Miroljub; Gregorc, Ales; Grigoryan, Karina; Hatjina, Fani; Ilyasov, Rustem; Ivanova, Evgeniya; Janashia, Irakli; Kandemir, Irfan; Karatasou, Aikaterini; Kekecoglu, Meral; Kezic, Nikola; Sz.Matray, Enikö; Mifsud, David; Moosbeckhofer, Rudolf; Nikolenko, Alexei G.; Papachristoforou, Alexandros; Petrov, Plamen; Pinto, M. Alice; Poskryakov, Aleksandr V.; Sharipov, Aglyam Y.; Siceanu, Adrian; Soysal, M.Ihsan; Uzunov, Aleksandar; Zammit-Mangion, Marion; Vingborg, Rikke; Bouga, Maria; Kryger, Per; Meixner, Marina D.; Estomba Recalde, Miren Andone (BMC, 2021-02-03)
Background With numerous endemic subspecies representing four of its five evolutionary lineages, Europe holds a large fraction of Apis mellifera genetic diversity. This diversity and the natural distribution range have ... -
Automatically exposing OpenLifeData via SADI semantic Web Services
; ; ; ; Egaña Aranguren, Mikel; ; (Biomed Central, 2014-11-19)
Background: Two distinct trends are emerging with respect to how data is shared, collected, and analyzed within the bioinformatics community. First, Linked Data, exposed as SPARQL endpoints, promises to make data easier ... -
Baseline tissue concentrations of metal in aquatic oligochaetes: field and laboratory approaches.
Méndez Fernández, Leire; Martínez Madrid, Maite ; ; (Elsevier, 2017-02-04)
Metal tissue residue evaluation in benthic macroinvertebrates is an important component of an integrated approach to ecological risk assessment of metals and metalloids in the Nalón River basin (North Spain), where historic ...