BackBrowsing Artículos by Author "Barreda Gómez, Gabriel"
Now showing items 1-20 of 21
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A UHPLC-Mass Spectrometry View of Human Melanocytic Cells Uncovers Potential Lipid Biomarkers of Melanoma
; ; ; ; ; Asumendi Mallea, Aintzane
; ; Fernández González, José Andrés ; Boyano López, María Dolores ; (MDPI, 2021-10-08)
Melanoma is the deadliest form of skin cancer due to its ability to colonize distant sites and initiate metastasis. Although these processes largely depend on the lipid-based cell membrane scaffold, our understanding of ... -
Acute Stress-Induced Changes in the Lipid Composition of Cow’s Milk in Healthy and Pathological Animals
; ; ; ; ; ; ; Simón Magro, Edurne; ; ; ; (2023-01-18)
Producers of milk and dairy products have been faced with the challenge of responding to European society’s demand for guaranteed animal welfare production. In recent years, measures have been taken to improve animal welfare ... -
Analysis of Acetylcholinesterase Activity in Cell Membrane Microarrays of Brain Areas as a Screening Tool to Identify Tissue Specific Inhibitors
Rienda Manrique, Bárbara; Elexpe, Ane; Tolentino Cortez, Tarson; Gulak, Marina; Bruzos Cidón, Cristina; Torrecilla Sesma, María ; Astigarraga Arribas, Egoitz; Barreda Gómez, Gabriel (MDPI, 2021-03-23)
Acetylcholinesterase (AChE) is responsible for hydrolyzing the acetylcholine neurotransmitter, bringing an end point to cholinergic neurotransmission. Thus, AChE is the primary target of a wide spectrum of compounds used ... -
Analysis of Mitochondrial Function in Cell Membranes as Indicator of Tissue Vulnerability to Drugs in Humans
Elexpe, Ane; Sánchez-Sánchez, Laura; Tolentino-Cortez, Tarson; Astigarraga Arribas, Egoitz; Torrecilla Sesma, María; Barreda Gómez, Gabriel (MDPI, 2022-04-23)
Drug side effects are one of the main reasons for treatment withdrawal during clinical trials. Reactive oxygen species formation is involved in many of the drug side effects, mainly by interacting with the components of ... -
Anatomical distribution of lipids in human brain cortex by imaging mass spectrometry
; ; ; Manuel Vicente, Iván; ; ; ; ; Rodríguez Puertas, Rafael ; Fernández González, José Andrés (Springer Verlag, 2011-01-28)
[ES] Las imágenes de masa molecular de los tejidos estarán sesgadas si las diferencias en las propiedades fisicoquímicas del microentorno afectan a la intensidad de los espectros. Para abordar esta cuestión, hemos realizado ... -
Characterization of the Antitumor Potential of Extracts of Cannabis sativa Strains with High CBD Content in Human Neuroblastoma
(MDPI, 2023-02-14)Cannabis has been used for decades as a palliative therapy in the treatment of cancer. This is because of its beneficial effects on the pain and nausea that patients can experience as a result of chemo/radiotherapy. ... -
Comparative lipidomic analysis of mammalian retinal ganglion cells and Muller glia in situ and in vitro using High-Resolution Imaging Mass Spectrometry
Pereiro Díez, Xandra; Fernández, Roberto; Barreda Gómez, Gabriel; Ruzafa Andrés, Noelia ; Acera Osa, Arantxa; Araiz Iribarren, José Javier; Astigarraga Arribas, Egoitz; Vecino Cordero, Elena (Nature, 2020-11-18)
In order to better understand retinal physiology, alterations to which underlie some ocular diseases, we set out to establish the lipid signature of two fundamental cell types in the retina, Muller Glia and Retinal Ganglion ... -
Dot Immunobinding Assay for the Rapid Serodetection of Scedosporium/Lomentospora in Cystic Fibrosis Patients
Martín Souto, Leire; Antorán Díaz, Aitziber ; ; ; ; ; ; ; ; ; ; ; ; (MDPI, 2023-01-24)
The detection of Scedosporium/Lomentospora is still based on non-standardized low-sensitivity culture procedures. This fact is particularly worrying in patients with cystic fibrosis (CF), where these fungi are the second ... -
Effects of galanin subchronic treatment on memory and muscarinic receptors.
; ; ; Manuel Vicente, Iván; Rodríguez Puertas, Rafael (Elsevier, 2015-05-07)
Las vías colinérgicas, que se originan en el prosencéfalo basal y son responsables del control de diferentes procesos cognitivos como el aprendizaje y la memoria también están reguladas por algunos neuropéptidos. Uno de ... -
Elevation of Tear MMP-9 Concentration as a Biomarker of Inflammation in Ocular Pathology by Antibody Microarray Immunodetection Assays
De la Fuente López, Miguel; Rodríguez Agirretxe, Ignacio; Vecino Cordero, Elena; Astigarraga Arribas, Egoitz; Acera Osa, Arantxa; Barreda Gómez, Gabriel (MDPI, 2022-05-18)
Matrix metalloproteinases are a family of enzymes fundamental in inflammatory processes. Between them, MMP-9 is up-regulated during inflammation; thus, its quantification in non-invasive fluids is a promising approach for ... -
Enzyme Therapy: Current Challenges and Future Perspectives
De la Fuente López, Miguel; Lombardero, Laura; Gómez-González, Alfonso; Solari, Cristina; Angulo Barturen, Iñigo; Acera Osa, Arantxa; Vecino Cordero, Elena; Astigarraga, Egoitz; Barreda Gómez, Gabriel (MDPI, 2021-08-25)
In recent years, enzymes have risen as promising therapeutic tools for different pathologies, from metabolic deficiencies, such as fibrosis conditions, ocular pathologies or joint problems, to cancer or cardiovascular ... -
Lipid fingerprint-based histology accurately classifies nevus, primary melanoma, and metastatic melanoma samples
; ; ; Fernández Regueira, Roberto Antonio; ; ; ; ; Asumendi Mallea, Aintzane ; ; ; ; ; Boyano López, María Dolores ; Fernández González, José Andrés (Wiley, 2024-02)
Probably, the most important factor for the survival of a melanoma patient is early detection and precise diagnosis. Although in most cases these tasks are readily carried out by pathologists and dermatologists, there are ... -
Microarrays, Enzymatic Assays, and MALDI-MS for Determining Specific Alterations to Mitochondrial Electron Transport Chain Activity, ROS Formation, and Lipid Composition in a Monkey Model of Parkinson’s Disease
; ; ; Rodríguez Puertas, Rafael; ; Manuel Vicente, Iván ; (MDPI, 2023-03-13)
Multiple evidences suggest that mitochondrial dysfunction is implicated in the pathogenesis of Parkinson’s disease via the selective cell death of dopaminergic neurons, such as that which occurs after prolonged exposure ... -
Mitochondrial Metabolism in Major Depressive Disorder: From Early Diagnosis to Emerging Treatment Options
; ; ; ; Torrecilla Sesma, María; ; (MDPI, 2024-03-17)
Major Depressive Disorder (MDD) is one of the most disabling diseases in the world. MDD is traditionally diagnosed based on a patient’s symptoms, which can lead to misdiagnosis. Although the pathogenic mechanisms of MDD ... -
Neuroanatomical characterization of the G protein-coupled receptor activity evoked by galanin-related ligands
; Manuel Vicente, Iván; Rodríguez Puertas, Rafael (Elsevier, 2023-03)
Galanin neuropeptide is distributed throughout the mammalian nervous system modulating a plethora of diverse physiological functions, including nociception, cognition and neuroendocrine regulation. The regulation of the ... -
Neuroinflammation in the Evolution of Motor Function in Stroke and Trauma Patients: Treatment and Potential Biomarkers
; ; ; Torrecilla Sesma, María; ; (MDPI, 2023-10-25)
Neuroinflammation has a significant impact on different pathologies, such as stroke or spinal cord injury, intervening in their pathophysiology: expansion, progression, and resolution. Neuroinflammation involves oxidative ... -
Review of Technological Challenges in Personalised Medicine and Early Diagnosis of Neurodegenerative Disorders
(MDPI, 2023-02-07)Neurodegenerative disorders are characterised by progressive neuron loss in specific brain areas. The most common are Alzheimer’s disease and Parkinson’s disease; in both cases, diagnosis is based on clinical tests with ... -
Serological Antibodies against Kidney, Liver, and Spleen Membrane Antigens as Potential Biomarkers in Patients with Immune Disorders
(MDPI, 2024-02-07)Immune disorders arise from complex genetic and environmental factors, which lead to dysregulation at the cellular and inflammatory levels and cause tissue damage. Recent research highlights the crucial role of reactive ... -
Spinal Inhibition of GABAB Receptors by the Extracellular Matrix Protein Fibulin-2 in Neuropathic Rats
Papon, Marie Amélie; Le Feuvre, Yves; Barreda Gómez, Gabriel; Favereaux, Alexandre; Farrugia, Fanny; Bouali Benazzouz, Rabia; Nagy, Frédéric; Rodríguez Puertas, Rafael; Landry, Marc (Frontiers Media, 2020-07-15)
In the central nervous system, the inhibitory GABAB receptor is the archetype of heterodimeric G protein-coupled receptors (GPCRs). Receptor interaction with partner proteins has emerged as a novel mechanism to alter GPCR ... -
Study of Tissue-Specific Reactive Oxygen Species Formation by Cell Membrane Microarrays for the Characterization of Bioactive Compounds
Elexpe, Ane; Nieto, Nerea; Fernández Cuétara, Claudia; Domínguez Fernández, Celtia; ; Torrecilla Sesma, María; Miguélez Palomo, Cristina; Laso, Antonio; Ochoa, Eneko; Bailen, María; González Coloma, Azucena; Angulo Barturen, Iñigo; Astigarraga, Egoitz; Barreda Gómez, Gabriel (MDPI, 2021-11-29)
The production of reactive oxygen species (ROS) increases considerably in situations of cellular stress, inducing lipid peroxidation and multiple alterations in proteins and nucleic acids. However, sensitivity to oxidative ...