Browsing Artículos by Author "Berg, Thorsten"

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      Nutlin-3a-aa: Improving the Bioactivity of a p53/MDM2 Interaction Inhibitor by Introducing a Solvent-Exposed Methylene Group 

      Nietzold, Florian; Rubner, Stefan; Labuzek, Beata; Golik, Przemyslaw; Surmiak, Ewa; Del Corte Solaguren-Beascoa, Xabier; Kitel, Radoslaw; Protzel, Christoph; Reppich-Sacher, Regina; Stichel, Jan; Magiera-Mularz, Katarzyna; Holak, Tad A. A.; Berg, Thorsten (Wiley, 2023-03)
      Nutlin-3a is a reversible inhibitor of the p53/MDM2 interaction. We have synthesized the derivative Nutlin-3a-aa bearing an additional exocyclic methylene group in the piperazinone moiety. Nutlin-3a-aa is more active than ...