Browsing Artículos by Author "Boons, Geert-Jan"
Now showing items 1-3 of 3
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Mono and Di-Fucosylated Glycans of the Parasitic Worm S. Mansoniare Recognized Differently by the Innate Immune Receptor DC-SIGN
Srivastava, Apoorva D.; Unione, Luca; Wolfert, Margreet A.; Valverde, Pablo; Ardá, Ana ; Jiménez Barbero, Jesús ; Boons, Geert-Jan (Wiley, 2020-12-01)The parasitic worm,Schistosoma mansoni, expresses unusual fucosylated glycans in a stage-dependent manner that can be recognized by the human innate immune receptor DC-SIGN, thereby shaping host immune responses. We have ... -
Revealing the Specificity of Human H1 Influenza A Viruses to Complex N-Glycans
Canales, Ángeles; Sastre, Javier; Orduña, José María; Spruit, Cindy M.; Pérez Castells, Javier; Domínguez, Gema; Bouwman, Kim M.; van der Woude, Roosmarijn; Cañada Vicinay, Francisco Javier; Nycholat, Corwin M.; Paulson, James C.; Boons, Geert-Jan; Jiménez Barbero, Jesús ; de Vries, Robert P. (American Chemical Society, 2023-02)Influenza virus infection remains a threat to human health since viral hemagglutinins are constantly drifting, escaping infection and vaccine-induced antibody responses. Viral hemag-glutinins from different viruses display ... -
Selective C-13-Labels on Repeating Glycan Oligomers to Reveal Protein Binding Epitopes through NMR: Polylactosamine Binding to Galectins
Moure, María J.; Gimeno, Ana; Delgado, Sandra; Diercks, Tammo; Boons, Geert-Jan; Jiménez Barbero, Jesús ; Ardá, Ana (Wiley, 2021-08-16)A combined chemo-enzymatic synthesis/NMR-based methodology is presented to identify, in unambiguous manner, the distinctive binding epitope within repeating sugar oligomers when binding to protein receptors. The concept ...