Browsing Artículos by Author "Burn Aschner, Clare"

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      Engineering pan–HIV-1 neutralization potency through multispecific antibody avidity 

      Rujas Díez, Edurne; Cui, Hong; Burnie, Jonathan; Burn Aschner, Clare; Zhao, Tiantian; Insausti González, Sara; Muthuraman, Krithika; Semesi, Anthony; Ophel, Jasper; Nieva Escandón, José Luis; Seaman, Michael S.; Guzzo, Christina; Treanor, Bebhinn; Julien, Jean-Philippe (National Academy of Sciences of the United States of America, 2022-01-25)
      Deep mining of B cell repertoires of HIV-1-infected individuals has resulted in the isolation of dozens of HIV-1 broadly neutralizing antibodies (bNAbs). Yet, it remains uncertain whether any such bNAbs alone are sufficiently ...
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      Multivalency Transforms SARS-CoV-2 Antibodies Into Ultrapotent Neutralizers 

      Rujas Díez, Edurne; Kucharska, Iga; Tan, Yong Zi; Benlekbir, Samir; Cui, Hong; Zhao, Tiantian; Wasney, Gregory A.; Budylowski, Patrick; Guvenc, Furkan; Newton, Jocelyn C.; Sicard, Taylor; Semesi, Anthony; Muthuraman, Krithika; Nouanesengsy, Amy; Burn Aschner, Clare; Prieto, Katherine; Bueler, Stephanie A.; Youssef, Sawsan; Liao-Chan, Sindy; Glanville, Jacob; Christie-Holmes, Natasha; Mubareka, Samira; Gray-Owen, Scott D.; Rubinstein, John L.; Treanor, Bebhinn; Julien, Jean-Philippe (Nature, 2021-06-16)
      SARS-CoV-2, the virus responsible for COVID-19, has caused a global pandemic. Antibodies can be powerful biotherapeutics to fight viral infections. Here, we use the human apoferritin protomer as a modular subunit to drive ...