Browsing Artículos by Author "Encinas Pérez, Juan Manuel"
Now showing items 1-13 of 13
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Alterations of the Hippocampal Neurogenic Niche in a Mouse Model of Dravet Syndrome
Martín Suárez, Soraya; Abiega Etxabe, Oihane; Ricobaraza, Ana; Hernández Alcoceba, Rubén; Encinas Pérez, Juan Manuel (Frontiers Media, 2020-07-21)Hippocampal neurogenesis, the process by which neural stem cells (NSCs) continuously generate new neurons in the dentate gyrus (DG) of most mammals including humans, is chiefly regulated by neuronal activity. Thus, severe ... -
BASP1 labels neural stem cells in the neurogenic niches of mammalian brain
Manganas, Louis N.; Durá, Irene; Osenberg, Sivan; Semerci, Faith; Tosun, Mehmet; Mishra, Rachana; Parkitny, Luke; Encinas Pérez, Juan Manuel; Maletic Savatic, Mirjana (Springer Nature, 2021-03-10)The mechanisms responsible for determining neural stem cell fate are numerous and complex. To begin to identify the specific components involved in these processes, we generated several mouse neural stem cell (NSC) antibodies ... -
BDNF and NT3 Reprogram Human Ectomesenchymal Dental Pulp Stem Cells to Neurogenic and Gliogenic Neural Crest Progenitors Cultured in Serum-Free Medium
Luzuriaga González, Jon; Pineda Martí, José Ramón
; Irastorza Epelde, Igor
; Uribe Etxebarria, Veronica; García Gallastegui, Patricia
; Encinas Pérez, Juan Manuel; Chamero, Pablo; Unda Rodríguez, Fernando José
; Ibarretxe Bilbao, Gaskon
(Cell Physiol Biochem Press, 2019-05-11)
Background/aims: Human Dental Pulp Stem Cells (hDPSCs) are one of the most promising types of cells to regenerate nerve tissues. Standard DMEM+10% fetal bovine serum (FBS) culture medium allows a fast expansion of hDPSC ... -
Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain
Schouten, Marijn; Bielefeld, Pascal; García Corzo, L.; Passchier, E. M. J.; Gradari, S.; Jungenitz, T.; Pons Espinal, M.; Gebara, E.; Martín Suárez, Soraya; Lucassen, Paul J.; De Vries, H. E.; Trejo Pérez, Jose Luis; Schwarzacher, S. W.; De Pietri Tonelli, D.; Toni, N.; Mira, H.; Encinas Pérez, Juan Manuel; Fitzsimons, Carlos P. (Springer, 2019-06-20)A decrease in adult hippocampal neurogenesis has been linked to age-related cognitive impairment. However, the mechanisms involved in this age-related reduction remain elusive. Glucocorticoid hormones (GC) are important ... -
Co-administration of Anti microRNA-124 and -137 Oligonucleotides Prevents Hippocampal Neural Stem Cell Loss Upon Non-convulsive Seizures
Bielefeld, Pascal; Schouten, Marijn; Meijer, Guido M.; Breuk, Marit J.; Geijtenbeek, Karlijne; Karayel, Sedef; Tiaglik, Alisa; Vuuregge, Anna H.; Willems, Ruth A.L.; Witkamp, Diede; Lucassen, Paul J.; Encinas Pérez, Juan Manuel; Fitzsimons, Carlos P. (Frontiers Media, 2019-02-19)Convulsive seizures promote adult hippocampal neurogenesis (AHN) through a transient activation of neural stem/progenitor cells (NSPCs) in the subgranular zone (SGZ) of the dentate gyrus (DG). However, in a significant ... -
Damage-responsive neuro-glial clusters coordinate the recruitment of dormant neural stem cells in Drosophila
Simoes, Anabel R.; Neto, Marta; Alves, Carolina S.; Santos, Mariana B.; Fernández Hernández, Ismael; Veiga Fernandes, Henrique; Brea, David; Durá, Irene; Encinas Pérez, Juan Manuel; Rhiner, Christa (Elsevier, 2022-07)[EN] Recruitment of stem cells is crucial for tissue repair. Although stem cell niches can provide important signals, little is known about mechanisms that coordinate the engagement of disseminated stem cells across an ... -
Dbx1-Derived Pyramidal Neurons Are Generated Locally in the Developing Murine Neocortex
Rueda-Alaña, Eneritz; Martínez-Garay, Isabel; Encinas Pérez, Juan Manuel; Molnár, Zoltán; García Moreno, Fernando (Frontiers Media, 2018-10-31)The neocortex (NCx) generates at the dorsal region of the pallium in the forebrain. Several adjacent structures also contribute with neurons to NCx. Ventral pallium (VP) is considered to generate several populations of ... -
Human DenPulp Stem Cells Grown in Neurogenic Media Differentiate Into Endothelial Cells and Promote Neovasculogenesis in the Mouse Brain
Luzuriaga González, Jon; Pastor Alonso, Oier; Encinas Pérez, Juan Manuel; Unda Rodríguez, Fernando José
; Ibarretxe Bilbao, Gaskon
; Pineda Martí, José Ramón
(Frontiers Media, 2019-03-28)
Dental pulp stem cells (DPSCs) have the capacity to give rise to cells with neuronal-like phenotypes, suggesting their use in brain cell therapies. In the present work, we wanted to address the phenotypic fate of adult ... -
Lysophosphatidic Acid Receptor 1 Specifically Labels Seizure-Induced Hippocampal Reactive Neural Stem Cells and Regulates Their Division
Valcárcel Martín, Roberto; Martín Suárez, Soraya; Muro García, Teresa; Pastor Alonso, Oier; Rodríguez de Fonseca, Fernando; Estivill Torrús, Guillermo; Encinas Pérez, Juan Manuel (Frontiers Media, 2020-08-14)
A population of neural stem cells (NSCs) dwelling in the dentate gyrus (DG) is able to generate neurons throughout adult life in the hippocampus of most mammals. These NSCs generate also astrocytes naturally and are capable ... -
Neuropathological Characterization of a Dravet Syndrome Knock-In Mouse Model Useful for Investigating Cannabinoid Treatments
Satta, Valentina; Alonso, Cristina; Díez, Paula; Martín Suárez, Soraya; Rubio, Marta; Encinas Pérez, Juan Manuel; Fernández Ruiz, Javier; Sagredo Ezkioga, Onintza (Frontiers Media, 2021-01-29)Dravet syndrome (DS) is an epileptic syndrome caused by mutations in the Scn1a gene encoding the alpha 1 subunit of the sodium channel Nav1.1, which is associated with febrile seizures that progress to severe tonic-clonic ... -
Perspective: Of Mice and Men - How Widespread Is Adult Neurogenesis?
Petrik, David; Encinas Pérez, Juan Manuel (Frontiers Media, 2019-08-29)These are exciting times for research on adult hippocampal neurogenesis (AHN). Debate and controversy regarding the existence of generation of new neurons in the adult, and even diseased human brain flourishes as articles ... -
Phenotypical and functional heterogeneity of neural stem cells in the aged hippocampus
Martín Suárez, Soraya; Valero Gómez-Lobo, Jorge; Muro García, Teresa; Encinas Pérez, Juan Manuel (Wiley, 2019-08)Adult neurogenesis persists in the hippocampus of most mammal species during postnatal and adult life, including humans, although it declines markedly with age. The mechanisms driving the age-dependent decline of hippocampal ... -
Reactive Disruption of the Hippocampal Neurogenic Niche After Induction of Seizures by Injection of Kainic Acid in the Amygdala
Muro García, Teresa; Martín Suárez, Soraya; Espinosa, Nelson; Valcárcel Martín, Roberto; Marinas, Ainhoa; Zaldumbide Dueñas, Laura; Galbarriatu, Lara; Sierra Saavedra, Amanda; Fuentealba, Pablo; Encinas Pérez, Juan Manuel (Frontiers Media, 2019-08-20)
Adult neurogenesis persists in the adult hippocampus due to the presence of multipotent neural stem cells (NSCs). Hippocampal neurogenesis is involved in a range of cognitive functions and is tightly regulated by neuronal ...