BackBrowsing Artículos by Author "Goikoetxea Usandizaga, Naroa"
Now showing items 1-8 of 8
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Anti-miR-518d-5p Overcomes Liver Tumor Cell Death Resistance Through Mitochondrial Activity
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Bañales Asurmendi, Jesús María
; ; ; ; ; ; ; Martínez Chantar, María Luz (Springer Nature, 2021-05-28)
Dysregulation of miRNAs is a hallmark of cancer, modulating oncogenes, tumor suppressors, and drug responsiveness. The multi-kinase inhibitor sorafenib is one of the first-line drugs for advanced hepatocellular carcinoma ... -
Magnesium Accumulation Upon Cyclin M4 Silencing Activates Microsomal Triglyceride Transfer Protein Improving NASH
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Martínez Chantar, María Luz (Elsevier, 2021-07)
Background & Aims: Perturbations of intracellular magnesium (Mg2+) homeostasis have implications for cell physiology. The cyclin M family, CNNM, perform key functions in the transport of Mg2+ across cell membranes. Herein, ... -
Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis
; Buqué García, Xabier; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Aurrekoetxea Galindo, Igor ; ; ; ; ; ; ; Bañales Asurmendi, Jesús María ; ; ; Martínez Chantar, María Luz ; ; (Nature, 2022)
Altered methionine metabolism is associated with weight gain in obesity. The methionine adenosyltransferase (MAT), catalyzing the first reaction of the methionine cycle, plays an important role regulating lipid metabolism. ... -
Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals
Goikoetxea Usandizaga, Naroa; ; Delgado, Teresa C.; Simón Espinosa, Jorge; Fernández Ramos, David; Barriales, Diego; Cornide, María E.; Jiménez, Mónica; Pérez Redondo, Marina; Lachiondo Ortega, Sofía; Rodríguez Agudo, Rubén; Bizkarguenaga, Maider; Diego Zalamea, Juan; Pasco, Samuel T.; Caballero Díaz, Daniel; Alfano, Benedetta; Bravo Garmendia, Miren; González Recio, Irene; Mercado Gómez, María; Gil Pitarch, Clàudia; Mabe Alvarez, Jon; Gracia Sancho, Jordi; Abecia Aliende, Leticia; Lorenzo, Oscar; Martín Sanz, Paloma; Abrescia, Nicola A.G.; Sabio, Guadalupe; Rincón, Mercedes; Anguita Castillo, Juan de Dios; Miñambres, Eduardo; Martín, César; Berenguer, Marina; Fabregat, Isabel; Casado, Marta; Peralta, Carmen; Varela Rey, Marta; Martínez Chantar, María Luz (Wiley, 2022-03)
[EN] Background and Aims Hepatic ischemia-reperfusion injury (IRI) is the leading cause of early posttransplantation organ failure as mitochondrial respiration and ATP production are affected. A shortage of donors has ... -
Multi-Omics Integration Highlights the Role of Ubiquitination in CCl4-Induced Liver Fibrosis
; ; ; ; ; ; ; ; ; ; ; ; Arizmendi Bastarrika, Jesús María; ; ; ; Ávila, Matías A. ; Bañales Asurmendi, Jesús María ; ; ; ; ; ; ; Mayor Martínez, Ugo ; Martínez Chantar, María Luz ; (MDPI, 2020-11-27)
Liver fibrosis is the excessive accumulation of extracellular matrix proteins that occurs in chronic liver disease. Ubiquitination is a post-translational modification that is crucial for a plethora of physiological ... -
Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via DEPTOR-mTOR axis
; ; ; ; ; ; ; ; ; ; ; ; ; Buqué García, Xabier; ; ; ; ; ; Bañales Asurmendi, Jesús María ; Ávila, Matías A. ; ; ; ; ; Mayor Martínez, Ugo ; ; ; ; ; Martínez Chantar, María Luz (Elsevier, 2021-06-18)
[EN] Objective: Neddylation is a druggable and reversible ubiquitin-like post-translational modification upregulated in many diseases, including liver fibrosis, hepatocellular carcinoma, and more recently, non-alcoholic ... -
Nutraceutical Properties of Polyphenols against Liver Diseases
Simón Espinosa, Jorge; Casado Andrés, María del Rosario; Goikoetxea Usandizaga, Naroa; ; Martínez Chantar, María Luz (MDPI, 2020-11-15)
Current food tendencies, suboptimal dietary habits and a sedentary lifestyle are spreading metabolic disorders worldwide. Consequently, the prevalence of liver pathologies is increasing, as it is the main metabolic organ ... -
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage
; ; ; ; ; ; ; ; ; ; ; Abecia Aliende, Leticia; ; ; ; ; ; ; ; Ávila, Matías A. ; ; ; ; ; ; ; ; ; ; ; ; Martínez Chantar, María Luz (Nature, 2022-11)
Drug induced liver injury (DILI) is an important cause acute liver failure. Here the authors report that serum Mg2+ serum levels decrease in patients with DILI as well as in preclinical animal models treated with acetaminophen ...