Now showing items 1-8 of 8

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      Anti-miR-518d-5p Overcomes Liver Tumor Cell Death Resistance Through Mitochondrial Activity 

      Fernández Tussy, Pablo; Rodríguez Agudo, Rubén; Fernández Ramos, David; Barbier Torres, Lucía; Zubiete Franco, Imanol; López de Davalillo, Sergio; Herráez Aguilar, Elisa; Goikoetxea Usandizaga, Naroa; Lachiondo Ortega, Sofía; Simón Espinosa, Jorge; Lopitz Otsoa, Fernando; Gutiérrez de Juan, Virginia; McCain, Misti V.; Perugorria Montiel, María Jesús; Mabe Alvarez, Jon; Navasa, Nicolás; Rodrigues, Cecilia M. P.; Fabregat, Isabel; Boix, Loreto; Sapena, Victor; Anguita Castillo, Juan de Dios; Lu, Shelly C.; Mato, José M.; Bañales Asurmendi, Jesús María ORCID; Villa, Erica; Reeves, Helen L.; Bruix, Jordi; Reig, María; Marín, José J. G.; Cardoso Delgado, Teresa de Jesús; Martínez Chantar, María Luz ORCID (Springer Nature, 2021-05-28)
      Dysregulation of miRNAs is a hallmark of cancer, modulating oncogenes, tumor suppressors, and drug responsiveness. The multi-kinase inhibitor sorafenib is one of the first-line drugs for advanced hepatocellular carcinoma ...
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      Magnesium Accumulation Upon Cyclin M4 Silencing Activates Microsomal Triglyceride Transfer Protein Improving NASH 

      Simón Espinosa, Jorge; Goikoetxea Usandizaga, Naroa; Serrano Maciá, Marina; Fernández Ramos, David; Saenz de Urturi Indart, Diego; Gruskos, Jessica J.; Fernández Tussy, Pablo; Lachiondo Ortega, Sofía; González Recio, Irene; Rodríguez Agudo, Rubén; Gutiérrez de Juan, Virginia; Rodríguez Iruretagoyena, Begoña; Varela Rey, Marta; Giménez Mascarell, Paula; Mercado Gómez, María; Gómez Santos, Beatriz; Fernández Rodríguez, Carmen; Lopitz Otsoa, Fernando; Bizkarguenaga, Maider; Dames, Sibylle; Schaeper, Ute; Martin, Franz; Sabio, Guadalupe; Iruzubieta, Paula; Crespo, Javier; Aspichueta Celaá, Patricia; Chu, Kevan H. Y.; Buccella, Daniela; Martín Plágaro, César Augusto; Cardoso Delgado, Teresa de Jesús; Martínez de la Cruz, Alfonso; Martínez Chantar, María Luz ORCID (Elsevier, 2021-07)
      Background & Aims: Perturbations of intracellular magnesium (Mg2+) homeostasis have implications for cell physiology. The cyclin M family, CNNM, perform key functions in the transport of Mg2+ across cell membranes. Herein, ...
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      Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis 

      Saenz de Urturi Indart, Diego; Buqué García, Xabier ORCID; Porteiro, Begoña; Folgueira, Cintia; Mora, Alfonso; Delgado, Teresa C.; Prieto Fernández, Endika; Olaizola Rebe, Paula; Gómez Santos, Beatriz; Apodaka Biguri, Maider; González Romero, Francisco; Nieva Zuluaga, Ane; Ruiz de Gauna Madariaga, Mikel; Goikoetxea Usandizaga, Naroa; García Rodríguez, Juan Luis; Gutiérrez de Juan, Virginia; Aurrekoetxea Galindo, Igor ORCID; Montalvo Romeral, Valle; Novoa, Eva; Martín Guerrero, Idoia; Varela Rey, Marta; Bhanot, Sanjay; Lee, Richard; Bañales Asurmendi, Jesús María ORCID; Syn, Wing-Kin; Sabio, Guadalupe; Martínez Chantar, María Luz ORCID; Nogueiras Pozo, Rubén; Aspichueta Celaá, Patricia (Nature, 2022)
      Altered methionine metabolism is associated with weight gain in obesity. The methionine adenosyltransferase (MAT), catalyzing the first reaction of the methionine cycle, plays an important role regulating lipid metabolism. ...
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      Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals 

      Goikoetxea Usandizaga, Naroa; Serrano Maciá, Marina; Delgado, Teresa C.; Simón Espinosa, Jorge; Fernández Ramos, David; Barriales, Diego; Cornide, María E.; Jiménez, Mónica; Pérez Redondo, Marina; Lachiondo Ortega, Sofía; Rodríguez Agudo, Rubén; Bizkarguenaga, Maider; Diego Zalamea, Juan; Pasco, Samuel T.; Caballero Díaz, Daniel; Alfano, Benedetta; Bravo Garmendia, Miren; González Recio, Irene; Mercado Gómez, María; Gil Pitarch, Clàudia; Mabe Alvarez, Jon; Gracia Sancho, Jordi; Abecia Aliende, Leticia ORCID; Lorenzo, Oscar; Martín Sanz, Paloma; Abrescia, Nicola A.G.; Sabio, Guadalupe; Rincón, Mercedes; Anguita Castillo, Juan de Dios; Miñambres, Eduardo; Martín, César; Berenguer, Marina; Fabregat, Isabel; Casado, Marta; Peralta, Carmen; Varela Rey, Marta; Martínez Chantar, María Luz ORCID (Wiley, 2022-03)
      [EN] Background and Aims Hepatic ischemia-reperfusion injury (IRI) is the leading cause of early posttransplantation organ failure as mitochondrial respiration and ATP production are affected. A shortage of donors has ...
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      Multi-Omics Integration Highlights the Role of Ubiquitination in CCl4-Induced Liver Fibrosis 

      Mercado Gómez, María; Lopitz Otsoa, Fernando; Azkargorta, Mikel; Serrano Maciá, Marina; Lachiondo Ortega, Sofía; Goikoetxea Usandizaga, Naroa; Rodríguez Agudo, Rubén; Fernández Ramos, David; Bizkarguenaga, Maider; Gutiérrez de Juan, Virginia; Lectez, Benoit; Aloria Escolastico, Kerman; Arizmendi Bastarrika, Jesús María ORCID; Simón Espinosa, Jorge; Alonso, Cristina; Lozano, Juan José; Ávila, Matías A. ORCID; Bañales Asurmendi, Jesús María ORCID; Marin, Jose J. G.; Beraza, Naiara; Mato, José M.; Elortza, Felix; Barrio Olano, María Rosa; Sutherland, James D.; Mayor Martínez, Ugo ORCID; Martínez Chantar, María Luz ORCID; Cardoso Delgado, Teresa de Jesús (MDPI, 2020-11-27)
      Liver fibrosis is the excessive accumulation of extracellular matrix proteins that occurs in chronic liver disease. Ubiquitination is a post-translational modification that is crucial for a plethora of physiological ...
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      Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via DEPTOR-mTOR axis 

      Serrano Maciá, Marina; Simon, Jorge; González Rellán, María Jesús; Azkargorta, Mikel; Goikoetxea Usandizaga, Naroa; Lopitz Otsoa, Fernando; Saenz de Urturi Indart, Diego; Rodríguez Agudo, Rubén; Lachiondo Ortega, Sofía; Mercado Gómez, María; Gutiérrez de Juan, Virginia; Bizkarguenaga, Maider; Fernández Ramos, David; Buqué García, Xabier ORCID; Baselli, Guido A.; Valenti, Luca; Iruzubieta, Paula; Crespo, Javier; Villa, Erica; Bañales Asurmendi, Jesús María ORCID; Ávila, Matías A. ORCID; Marin, José J. G.; Aspichueta Celaá, Patricia; Sutherland, James D.; Barrio Olano, María Rosa; Mayor Martínez, Ugo ORCID; Elortza, Felix; Xirodimas, Dimitri; Nogueiras Pozo, Rubén; Delgado, Teresa C.; Martínez Chantar, María Luz ORCID (Elsevier, 2021-06-18)
      [EN] Objective: Neddylation is a druggable and reversible ubiquitin-like post-translational modification upregulated in many diseases, including liver fibrosis, hepatocellular carcinoma, and more recently, non-alcoholic ...
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      Nutraceutical Properties of Polyphenols against Liver Diseases 

      Simón Espinosa, Jorge; Casado Andrés, María del Rosario ORCID; Goikoetxea Usandizaga, Naroa; Serrano Maciá, Marina; Martínez Chantar, María Luz ORCID (MDPI, 2020-11-15)
      Current food tendencies, suboptimal dietary habits and a sedentary lifestyle are spreading metabolic disorders worldwide. Consequently, the prevalence of liver pathologies is increasing, as it is the main metabolic organ ...
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      Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage 

      González Recio, Irene; Simón Espinosa, Jorge; Goikoetxea Usandizaga, Naroa; Serrano Maciá, Marina; Mercado Gómez, María; Rodríguez Agudo, Rubén; Lachiondo Ortega, Sofía; Gil Pitarch, Clàudia; Fernández Rodríguez, Carmen; Castellana, Donatello; Latasa, María Ujué; Abecia Aliende, Leticia ORCID; Anguita Castillo, Juan de Dios; Delgado, Teresa C.; Iruzubieta, Paula; Crespo, Javier; Hardy, Serge; Petrov, Petar D.; Jover, Ramiro; Ávila, Matías A. ORCID; Martín Plágaro, César Augusto; Schaeper, Ute; Tremblay, Michel L.; Dear, James W.; Masson, Steven; McCain, Misti Vanette; Reeves, Helen L.; Andrade, Raúl; Lucena, M. Isabel; Buccella, Daniela; Martínez de la Cruz, Alfonso; Martínez Chantar, María Luz ORCID (Nature, 2022-11)
      Drug induced liver injury (DILI) is an important cause acute liver failure. Here the authors report that serum Mg2+ serum levels decrease in patients with DILI as well as in preclinical animal models treated with acetaminophen ...