Browsing Artículos by Author "González Maeso, Javier"

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      Characterization of dopamine D2 receptor coupling to G proteins in postmortem brain of subjects with schizophrenia 

      Egusquiza, Iker; Munarriz Cuezva, Eva; Segarra Echevarria, Rafael; González Maeso, Javier; Callado Hernando, Luis Felipe ORCID; Meana Martínez, José Javier ORCID; Díez Alarcia, Rebeca ORCID (Springer, 2021-08)
      Background: Alterations of dopamine D-1 (D1R) and D-2 receptor (D2R) are proposed in schizophrenia but brain neuroimaging and postmortem studies have shown controversial results in relation to D1R and D2R density. Besides, ...
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      Dopaminergic control of ADAMTS2 expression through cAMP/CREB and ERK: molecular effects of antipsychotics 

      Ruso Julve, Fulgencio; Pombero, Ana; Pilar Cuéllar, Fuencisla; García Díaz, Nuria; Garcia López, Raquel; Juncal Ruiz, María; Castro, Elena; Díaz, Álvaro; Vazquez Bourgón, Javier; García Blanco, Agustín; Garro Martínez, Emilio; Pisonero, Helena; Estirado, Alicia; Ayesa Arriola, Rosa; López Giménez, Juan; Mayor, Federico; Valdizán, Elsa; Meana Martínez, José Javier ORCID; González Maeso, Javier; Martínez, Salvador; Vaqué, José Pedro; Crespo Facorro, Benedicto (Nature, 2019-11-18)
      A better understanding of the molecular mechanisms that participate in the development and clinical manifestations of schizophrenia can lead to improve our ability to diagnose and treat this disease. Previous data strongly ...
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      Glucocorticoid receptor dysregulation underlies 5-HT2AR-dependent synaptic and behavioral deficits in a mouse neurodevelopmental disorder model. 

      Saunders, Justin M.; Muguruza Millán, Carolina ORCID; Sierra, Salvador; Moreno, José L.; Callado Hernando, Luis Felipe ORCID; Meana Martínez, José Javier ORCID; Beardsley, Patrick M.; González Maeso, Javier (Elsevier, 2022-11)
      Prenatal environmental insults increase the risk of neurodevelopmental psychiatric conditions in the offspring. Structural modifications of dendritic spines are central to brain development and plasticity. Using maternal ...
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      Serotonin 5-HT2A receptor expression and functionality in postmortem frontal cortex of subjects with schizophrenia: Selective biased agonism via Gαi1-proteins 

      García Bea, Aintzane; Miranda Azpiazu, Patricia; Muguruza Millán, Carolina ORCID; Marmolejo Martínez-Arteseroa, Sara; Díez Alarcia, Rebeca ORCID; Gabilondo Urquijo, Ane Miren ORCID; Callado Hernando, Luis Felipe ORCID; Morentin Campillo, Benito; González Maeso, Javier; Meana Martínez, José Javier ORCID (Elsevier, 2019-12)
      Serotonin 5-HT2A receptors (5-HT(2A)Rs) have been implicated in schizophrenia. However, postmortem studies on 5-HT(2A)Rs expression and functionality in schizophrenia are scarce. The 5-HT2AR mRNA and immunoreactive protein ...