Listar Artículos por autor "Sáenz Antoñanzas, Ander"
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High SOX9 Maintains Glioma Stem Cell Activity through a Regulatory Loop Involving STAT3 and PML
Aldaz Donamaría, Paula; Martín Martín, Natalia; Sáenz Antoñanzas, Ander; Carrasco García, Estefanía; Álvarez-Satta, María; Elúa Pinin, Alejandro; Pollard, Steven M.; Lawrie, Charles H.; Moreno-Valladares, Manuel; Samprón Lebed, Nicolás; Hench, Jürgen; Lovell-Badge, Robin; Carracedo Pérez, Arkaitz; Matheu Fernández, Ander (MDPI, 2022-05)
Glioma stem cells (GSCs) are critical targets for glioma therapy. SOX9 is a transcription factor with critical roles during neurodevelopment, particularly within neural stem cells. Previous studies showed that high levels ... -
Myotonic Dystrophy type 1 cells display impaired metabolism and mitochondrial dysfunction that are reversed by metformin
García Puga, Mikel; Sáenz Antoñanzas, Ander; Fernández Torrón, Roberto; López de Munain Arregui, Adolfo José; Matheu Fernández, Ander (Impact Journals, 2020-04-15)Myotonic dystrophy type 1 (DM1; MIM #160900) is an autosomal dominant disorder, clinically characterized by progressive muscular weakness and multisystem degeneration. The broad phenotypes observed in patients with DM1 ... -
PR-LncRNA Signature Regulates Glioma Cell Activity Through Expression of SOX Factors
Torres Bayona, Sergio Andrés; Aldaz Donamaría, Paula; Auzmendi Iriarte, Jaione; Sáenz Antoñanzas, Ander; García Camino, Idoia; Arrazola Schlamilch, Mariano; Gerovska, Daniela; Undabeitia Huertas, José; Querejeta Ayerra, Arrate; Egaña Otaño, Larraitz; Villanua Bernues, Jorge Alberto; Ruiz Díaz, Irune; Sarasqueta Eizaguirre, Cristina; Urculo Bareño, Enrique; Araúzo Bravo, Marcos J.; Huarte Martínez, Maite; Samprón Lebed, Nicolás; Matheu Fernández, Ander (Nature Publishing Group, 2018-08-24)
Long non-coding RNAs (LncRNAs) have emerged as a relevant class of genome regulators involved in a broad range of biological processes and with important roles in tumor initiation and malignant progression. We have previously ... -
Senescence plays a role in myotonic dystrophy type 1 br
García Puga, Mikel; Sáenz Antoñanzas, Ander; Gereñu Lopetegi, Gorka; Arrieta Legorburu, Alex; Fernández Torrón, Roberto; Zulaica Ijurco, Miren; Sáenz Peña, Amets; Elizazu Pérez, Joseba; Nogales Gadea, Gisela; Gadalla, Shahinaz M.; Araúzo Bravo, Marcos J.; López de Munain Arregui, Adolfo José; Matheu Fernández, Ander (American Society for Clinical Investigation, 2022-10)Myotonic dystrophy type 1 (DM1; MIM #160900) is an autosomal dominant disorder, clinically characterized by progressive muscular weakness and multisystem degeneration. The broad phenotypes observed in patients with DM1 ... -
Targeting Myotonic Dystrophy Type 1 with Metformin
García Puga, Mikel; Sáenz Antoñanzas, Ander; Matheu Fernández, Ander; López de Munain Arregui, Adolfo José (MDPI, 2022-03)Myotonic dystrophy type 1 (DM1) is a multisystemic disorder of genetic origin. Progressive muscular weakness, atrophy and myotonia are its most prominent neuromuscular features, while additional clinical manifestations in ...