BackBrowsing Artículos by Author "Castellanos Rubio, Ainara"
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A long non-coding RNA that harbors a SNP associated with type 2 diabetes regulates the expression of TGM2 gene in pancreatic beta cells
González Moro, Itziar
; ; Sebastián de la Cruz, Maialen ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; (Frontiers Media, 2023-02)
IntroductionMost of the disease-associated single nucleotide polymorphisms (SNPs) lie in non- coding regions of the human genome. Many of these variants have been predicted to impact the expression and function of long ... -
A novel RT-QPCR-based assay for the relative quantification of residue specific m6A RNA methylation
; ; ; ; ; ; Bilbao Catalá, José Ramón (Nature Publishing Group, 2019-12)
N6-methyladenosine (m6A) is the most common and abundant RNA modification. Recent studies have shown its importance in the regulation of several biological processes, including the immune response, and different approaches ... -
A Novel, Noninvasive Method to Diagnose Active Eosinophilic Esophagitis, Combining Clinical Data and Oral Cavity RNA Levels
Sebastián de la Cruz, Maialen; ; Bilbao Catalá, José Ramón ; ; Bujanda Fernández de Pierola, Luis ; (Elsevier, 2024-03)
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Accuracy in Copy Number Calling by qPCR and PRT : A Matter of DNA
; ; ; ; Irastorza Terradillos, Iñaki Xarles; Castaño González, Luis Antonio ; ; Bilbao Catalá, José Ramón (Public Library of Science, 2011-12-13)
The possible implication of copy number variation (CNV) in the genetic susceptibility to human disease needs to be assessed using robust methods that can be applied at a population scale. In this report, we analyze the ... -
Celiac Diasease-associated lncRNA Named HCG14 Regulates NOD1 Expression in Intestinal Cells
; ; ; ; ; ; Fernández Jiménez, Nora; Irastorza Terradillos, Iñaki Xarles ; Castaño González, Luis Antonio ; Bilbao Catalá, José Ramón (Wiley, 2018-08-01)
Objective: The aim of the study is to identify additional celiac disease associated loci in the major histocompatibility complex (MHC) independent from classical HLA risk alleles (HLA-DR3-DQ2) and to characterize their ... -
Detection of Atomic Scale Changes in the Free Volume Void Size of Three-Dimensional Colorectal Cancer Cell Culture Using Positron Annihilation Lifetime Spectroscopy
Axpe Iza, Eneko; López Euba, Tamara; Castellanos Rubio, Ainara; Mérida Sanz, David; ; Plaza-Izurieta, Leticia; Fernández-Jiménez, Nora; Plazaola Muguruza, Fernando; Bilbao Catalá, José Ramón (Public Library of Science, 2014-01-02)
Positron annihilation lifetime spectroscopy (PALS) provides a direct measurement of the free volume void sizes in polymers and biological systems. This free volume is critical in explaining and understanding physical and ... -
DEXI, a candidate gene for type 1 diabetes, modulates rat and human pancreatic beta cell inflammation via regulation of the type I IFN/STAT signalling pathway
; ; ; ; ; ; ; Castaño González, Luis Antonio; (Springer, 2018-11-26)
Aims/hypothesis: The initial stages of type 1 diabetes are characterized by an aberrant islet inflammation that is in part regulated by the interaction between type 1 diabetes susceptibility genes and environmental factors. ... -
Disease-Associated SNPs in Inflammation-Related lncRNAs
(Frontiers Media, 2019-03-08)Immune-mediated diseases, such as celiac disease, type 1 diabetes or multiple sclerosis, are a clinically heterogeneous group of diseases that share many key genetic triggers. Although the pathogenic mechanisms responsible ... -
Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells
Olazagoitia Garmendia, Ane; Zhang, Linda; Mera, Paula; Godbout, Julie K.; Sebastián de la Cruz, Maialen; García Santisteban, Iraia ; Mendoza Gómez, Luis Manuel; Huerta Madrigal, Alain; Irastorza Terradillos, Iñaki Xarles ; Bhagat, Govind; Green, Peter H.; Herrero, Laura; Serra, Dolors; Rodríguez Pérez, José Antonio ; Verdú, Elena F.; He, Chuan; Bilbao Catalá, José Ramón ; Castellanos Rubio, Ainara (BMJ, 2022-01)
[EN] Objectives Coeliac disease (CD) is a complex autoimmune disorder that develops in genetically susceptible individuals. Dietary gluten triggers an immune response for which the only available treatment so far is a ... -
Highly Reproducible Hyperthermia Response in Water, Agar, and Cellular Environment by Discretely PEGylated Magnetite Nanoparticles
; ; ; ; Gil de Muro Zabala, Izaskun; ; Bilbao Catalá, José Ramón ; ; Plazaola Muguruza, Fernando ; Orue Goikuria, Iñaki ; ; (ACS American Chemical Society Publications, 2020-05-28)
Local heat generation from magnetic nanoparticles(MNPs) exposed to alternating magneticfields can revolutionizecancer treatment. However, the application of MNPs as anticanceragents is limited by serious drawbacks. Foremost ... -
Implication of m6A mRNA Methylation in Susceptibility to Inflammatory Bowel Disease
Sebastián de la Cruz, Maialen; ; González Moro, Itziar ; ; ; (MDPI, 2020-08-03)
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract that develops due to the interaction between genetic and environmental factors. More than 160 loci have been associated ... -
Isoreticular chemistry and applications of supramolecularly assembled copper−adenine porous materials
; Pascual Colino, Jon; Beobide Pacheco, Garikoitz ; Castillo García, Oscar ; ; Luque Arrebola, Antonio ; ; ; Pérez Yáñez, Sonia (American Chemical Society, 2023-11-01)
The useful concepts of reticular chemistry, rigid and predictable metal nodes together with strong and manageable covalent interactions between metal centers and organic linkers, have made the so-called metal–organic ... -
m6A Methylated Long Noncoding RNA LOC339803 Regulates Intestinal Inflammatory Response
; ; Sebastián de la Cruz, Maialen; ; ; ; ; Bujanda Fernández de Pierola, Luis ; ; ; (Wiley, 2024-04)
Cytokine mediated sustained inflammation increases the risk to develop different complex chronic inflammatory diseases, but the implicated mechanisms remain unclear. Increasing evidence shows that long noncoding RNAs ... -
MAGI2 Gene Region and Celiac Disease
; ; García Etxebarria, Koldo; Olazagoitia Garmendia, Ane; Romero Garmendia, Irati; Sebastián de la Cruz, Maialen; Irastorza Terradillos, Iñaki Xarles ; Spanish Consortium for the Genetics of Celiac Disease; Castellanos Rubio, Ainara; Bilbao Catalá, José Ramón (Frontiers Media, 2019-12-19)
Celiac disease (CD) patients present a loss of intestinal barrier function due to structural alterations in the tight junction (TJ) network, the most apical unions between epithelial cells. The association of TJ-related ... -
Shaping Up Zn-Doped Magnetite Nanoparticles from Mono- and Bimetallic Oleates: The Impact of Zn Content, Fe Vacancies, and Morphology on Magnetic Hyperthermia Performance
; Arriortua, Oihane; ; ; ; ; ; ; Plazaola Muguruza, Fernando ; ; ; ; Orue Goikuria, Iñaki ; (ACS American Chemical Society Publications, 2021-04-19)
The currently existing magnetic hyperthermia treatments usually need to employ very large doses of magnetic nanoparticles (MNPs) and/or excessively high excitation conditions (H × f > 1010 A/m s) to reach the therapeutic ... -
The methylome of the celiac intestinal epithelium harbours genotype-independent alterations in the HLA region
Fernández Jiménez, Nora; ; ; ; ; ; ; ; ; ; ; Irastorza Terradillos, Iñaki Xarles ; ; ; Bilbao Catalá, José Ramón (Nature Publishing, 2019-02-04)
The Human Leucocyte Antigen (HLA) locus and other DNA sequence variants identified in Genome-Wide Association (GWA) studies explain around 50% of the heritability of celiac disease (CD). However, the pathogenesis of CD ... -
The Role of lncRNAs in Gene Expression Regulation through mRNA Stabilization
Sebastián de la Cruz, Maialen; González Moro, Itziar ; Olazagoitia Garmendia, Ane; Castellanos Rubio, Ainara; (MDPI, 2021-01-05)
mRNA stability influences gene expression and translation in almost all living organisms, and the levels of mRNA molecules in the cell are determined by a balance between production and decay. Maintaining an accurate balance ... -
The T1D-associated lncRNA Lnc13 modulates human pancreatic β cell inflammation by allele-specific stabilization of STAT1 mRNA
González Moro, Itziar; ; ; ; ; ; ; ; ; ; ; (National Academy of Sciences, 2020-03-05)
The vast majority of type 1 diabetes (T1D) genetic association signals lie in non-coding regions of the human genome. Many have been predicted to affect the expression and secondary structure of long non-coding RNAs ...