BackBrowsing Artículos by Author "Cubiella, Joaquín"
Now showing items 1-12 of 12
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A new approach to epigenome-wide discovery of non-invasive methylation biomarkers for colorectal cancer screening in circulating cell-free DNA using pooled samples
Gallardo-Gómez, María; Moran, Sebastian; Páez de la Cadena, María; Martínez-Zorzano, Vicenta Soledad; Rodríguez-Berrocal, Francisco Javier; Rodríguez-Girondo, Mar; Esteller, Manel; Cubiella, Joaquín; Bujanda Fernández de Pierola, Luis
; Castells, Antoni; Balaguer, Francesc; Jover, Rodrigo; De Chiara, Loretta (Biomed Central, 2018-04-16)
Background: Colorectal cancer is the fourth cause of cancer-related deaths worldwide, though detection at early stages associates with good prognosis. Thus, there is a clear demand for novel non-invasive tests for the early ... -
A Novel Approach on the Use of Samples from Faecal Occult Blood Screening Kits for Metabolomics Analysis: Application in Colorectal Cancer Population
Albóniga Díez, Oihane Elena; ; Bujanda Fernández de Pierola, Luis ; ; ; ; ; (MDPI, 2023-02-21)
The incidence of colorectal cancer (CRC) is increasing, and currently it is the third most common cancer. Early CRC diagnosis is still difficult and relies on an invasive colonoscopy and tissue biopsy. The globally observed ... -
Colorectal Cancer Genetic Variants Are Also Associated with Serrated Polyposis Syndrome Susceptibility
Arnau Collell, Coral; Soares de Lima, Yasmin; Díaz Gay, Marcos; Muñoz, Jenifer; Carballal, Sabela; Bonjoch, Laia; Moreira, Leticia; Lozano, Juan José; Ocaña, Teresa; Cuatrecasas, Miriam; Díaz de Bustamante, Aranzazu; Castells, Antoni; Capella, Gabriel; Bujanda Fernández de Pierola, Luis; Cubiella, Joaquín; Rodríguez Alcalde, Daniel; Balaguer, Francesc; Ruiz Ponte, Clara; Valle, Laura; Moreno, Víctor; Castellví Bel, Sergi (BMJ Publishing Group, 2020-10)
Background Serrated polyposis syndrome (SPS) is a clinical entity characterised by large and/ormultiple serrated polyps throughout the colon and increased risk for colorectal cancer (CRC). The basis for SPS genetic ... -
Colorectal Cancer Survival in 50- to 69-Year-Olds after Introducing the Faecal Immunochemical Test
Gutierrez Stampa, María Angeles; Aguilar Gama, Vanessa; Sarasqueta Eizaguirre, Cristina; Cubiella, Joaquín; Portillo Villares, María Isabel; Bujanda Fernández de Pierola, Luis (MDPI, 2020-08-25)
Population screening has improved early diagnosis of colorectal cancer (CRC). Nonetheless, most cases are diagnosed in symptomatic patients. Faecal immunochemical testing has been recommended for assessing patients with ... -
Development and external validation of a faecal immunochemical test-based prediction model for colorectal cancer detection in symptomatic patients
Cubiella, Joaquín; Vega, Pablo; Salve, María; Díaz-Ondina, Marta; Alves, Maria Teresa; Quintero, Enrique; Álvarez-Sánchez, Victoria; Fernández-Bañares, Fernando; Boadas, Jaume; Campo, Rafel; Bujanda Fernández de Pierola, Luis; Clofent, Joan; Ferrandez, Ángel; Torrealba, Leyanira; Piñol, Virginia; Rodríguez-Alcalde, Daniel; Hernández, Vicent; Fernández-Seara, Javier; COLONPREDICT study investigators (Biomed Central, 2016-08-31)
Background: Risk prediction models for colorectal cancer (CRC) detection in symptomatic patients based on available biomarkers may improve CRC diagnosis. Our aim was to develop, compare with the NICE referral criteria and ... -
Identification of a Novel Candidate Gene for Serrated Polyposis Syndrome Germline Predisposition by Performing Linkage Analysis Combined With Whole-Exome Sequencing
Toma, Claudio; Díaz Gay, Marcos; Soares de Lima, Yasmin; Arnau Collell, Coral; Franch Expósito, Sebastià; Muñoz, Jenifer; Overs, Bronwyn; Bonjoch, Laia; Carballal, Sabela; Ocaña, Teresa; Cuatrecasas, Miriam; Díaz de Bustamante, Aranzazu; Castells, Antoni; Bujanda Fernández de Pierola, Luis; Cubiella, Joaquín; Balaguer, Francesc; Rodríguez Alcalde, Daniel; Fullerton, Janice M.; Castellví-Bel, Sergi (Lippincott Williams & Wilkins, 2019-09-19)
OBJECTIVES: Serrated polyposis syndrome (SPS) is a complex disorder with a high risk of colorectal cancer for which the germline factors remain largely unknown. Here, we combined whole-exome sequencing (WES) and linkage ... -
Increased Th17-Related Cytokine Serum Levels in Patients With Multiple Polyps of Unexplained Origin
Alustiza, Miren; Hernández Illán, Eva; Juárez, Miriam; Giner Calabuig, Mar; Mira, Cristina; Martínez Roca, Alejandro; Bujanda Fernández de Pierola, Luis; Rodríguez Moranta, Francisco; Cubiella, Joaquín; De Castro, Luisa; Marín Gabriel, José Carlos; Herreros de Tejada, Alberto; Fernández Bañares, Fernando; Nicolás Pérez, David; Giménez, Paula; Martínez Cardona, Claudia; Francés, Rubén; Murcia, Oscar; Jover, Rodrigo (Wolters Kluwer, 2020-03)
OBJECTIVES: Most patients with multiple colonic polyps do not have a known genetic or hereditary origin. Our aim was to analyze the presence of inflammatory cytokines and levels of glucose, insulin, and C-reactive protein ... -
Integrated Analysis of Germline and Tumor DNA Identifies New Candidate Genes Involved in Familial Colorectal Cancer
Díaz Gay, Marcos; Franch Expósito, Sebastià; Arnau Collell, Coral; Park, Solip; Supek, Fran; Muñoz, Jenifer; Bonjoch, Laia; Gratacós Mulleras, Anna; Sánchez Rojas, Paula A.; Esteban-Jurado, Clara; Ocaña, Teresa; Cuatrecasas, Miriam; Vila Casadesús, Maria; Lozano, Juan José; Parra, Genis; Laurie, Steve; Beltran, Sergi; EPICOLON Consortium; Castells, Antoni; Bujanda Fernández de Pierola, Luis; Cubiella, Joaquín; Balaguer, Francesc; Castellví-Bel, Sergi (MDPI, 2019-03-13)
Colorectal cancer (CRC) shows aggregation in some families but no alterations in the known hereditary CRC genes. We aimed to identify new candidate genes which are potentially involved in germline predisposition to familial ... -
Predictive Value of Carcinoembryonic Antigen in Symptomatic Patients without Colorectal Cancer: A Post-Hoc Analysis within the COLONPREDICT Cohort
Pin Vieito, Noel; Iglesias, María José; Remedios, David; Álvarez Sánchez, Victoria; Fernández Bañares, Fernando; Boadas, Jaume; Martínez Bauer, Eva; Campo, Rafael; Bujanda Fernández de Pierola, Luis; Ferrández, Ángel; Piñol, Virginia; Rodríguez Alcalde, Daniel; Menéndez Rodríguez, Martín; García Morales, Natalia; Pérez Mosquera, Cristina; Cubiella, Joaquín (MDPI, 2020-12-02)
We aimed to assess the risk of cancer in patients with abdominal symptoms after a complete colonoscopy without colorectal cancer (CRC), according to the carcinoembryonic antigen (CEA) concentration, as well as its diagnostic ... -
Risk of gastrointestinal cancer in a symptomatic cohort after a complete colonoscopy: role of faecal immunochemical test
Pin Vieito, Noel; Iglesias, María J; Remedios, David; Rodríguez Alonso, Lorena; Rodriguez Moranta, Francisco; Álvarez Sánchez, Victoria; Fernández Bañares, Fernando; Boadas, Jaume; Martínez Bauer, Eva; Campo, Rafael; Bujanda Fernández de Pierola, Luis; Ferrández, Ángel; Piñol, Virginia; Rodríguez Alcalde, Daniel; Guardiola, Jordi; Cubiella, Joaquín; COLONPREDICT study investigators (Baishideng Publishing, 2020-01-07)
BACKGROUND Faecal immunochemical test (FIT) has been recommended to assess symptomatic patients for colorectal cancer (CRC) detection. Nevertheless, some conditions could theoretically favour blood originating in proximal ... -
Symptom or faecal immunochemical test based referral criteria for colorectal cancer detection in symptomatic patients: a diagnostic tests study
Herrero, Jesús-Miguel; Vega, Pablo; Salve, María; Bujanda Fernández de Pierola, Luis; Cubiella, Joaquín (Biomed Central, 2018-10-25)
BackgroundSymptom based referral criteria for colorectal cancer (CRC) detection are the cornerstone of the strategy to improve prognosis in CRC. In 2017, the National Institute for Health and Care Excellence (NICE) updated ... -
Using linkage studies combined with whole-exome sequencing to identify novel candidate genes for familial colorectal cancer
Toma, Claudio; Díaz Gay, Marcos; Franch Expósito, Sebastià; Arnau Collell, Coral; Overs, Bronwyn; Muñoz, Jenifer; Bonjoch, Laia; Soares de Lima, Yasmin; Ocaña, Teresa; Cuatrecasas, Miriam; Castells, Antoni; Bujanda Fernández de Pierola, Luis; Balaguer, Francesc; Cubiella, Joaquín; Caldés, Trinidad; Fullerton, Janice M.; Castellví Bel, Sergi (Wiley, 2019-11)
Colorectal cancer (CRC) is a complex disorder for which the majority of the underlying germline predisposition factors remain still unidentified. Here, we combined whole-exome sequencing (WES) and linkage analysis in ...