Now showing items 1-20 of 24

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      Activation of Extracellular Signal-Regulated Kinases (ERK 1/2) in the Locus Coeruleus Contributes to Pain-Related Anxiety in Arthritic Male Rats 

      Borges, Gisela; Miguélez Palomo, Cristina; Neto, Fani; Mico, Juan Antonio; Ugedo Urruela, Luisa; Berrocoso, Esther (Oxford University Press, 2017-06)
      Background: There is increasing evidence suggesting that the Locus Coeruleus plays a role in pain-related anxiety. Indeed, we previously found that prolonged arthritis produces anxiety-like behavior in rats, along with ...
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      Alcohol-Related Brain Damage in Humans 

      Erdozain Fernández, Amaia Maite; Morentin, Benito; Bedford, Lynn; King, Emma; Tooth, David; Brewer, Charlotte; Wayne, Declan; Johnson, Laura; Gerdes, Henry K.; Wigmore, Peter; Callado Hernando, Luis Felipe; Carter, Wayne G. (Public Library Science, 2014-04-03)
      Chronic excessive alcohol intoxications evoke cumulative damage to tissues and organs. We examined prefrontal cortex (Brodmann's area (BA) 9) from 20 human alcoholics and 20 age, gender, and postmortem delay matched control ...
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      Behavioral, neurochemical and morphological changes induced by the overexpression of munc18-1a in brain of mice: relevance to schizophrenia 

      Urigüen Echeverría, Leyre; Gil Pisa, I.; Munarriz Cuezva, Eva; Berrocoso, E.; Pascau, J.; Soto Montenegro, M. L.; Gutiérrez Adán, A.; Pintado, B.; Madrigal, J. L. M.; Castro, E.; Sánchez Blázquez, P.; Ortega, J. E.; Guerrero, M. J.; Ferrer Alcon, M.; García Sevilla, J. A.; Mico, J. A.; Desco, M.; Leza, Juan Carlos; Pazos, A.; Garzon, J.; Meana Martínez, José Javier (Nature Publishing Group, 2013-01)
      Overexpression of the mammalian homolog of the unc-18 gene (munc18-1) has been described in the brain of subjects with schizophrenia. Munc18-1 protein is involved in membrane fusion processes, exocytosis and neurotransmitter ...
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      Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results 

      Fernández Fernández, Cristina; Callado Hernando, Luis Felipe; Girón, Rocío; Sánchez, Eva; Erdozain Fernández, Amaia Maite; López-Moreno, José Antonio; Morales, Paula; Rodríguez de Fonseca, Fernando; Fernández-Ruiz, Javier; Goya, Pilar; Meana Martínez, José Javier; Martín, Isabel; Jagerovic, Nadine (Dove Medical Press, 2014)
      Based on numerous pharmacological studies that have revealed an interaction between cannabinoid and opioid systems at the molecular, neurochemical, and behavioral levels, a new series of hybrid molecules has been prepared ...
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      Cytokine pathway disruption in a mouse model of schizophrenia induced by Munc18-1a overexpression in the brain 

      Gil de la Pisa, Itziar; Cebrián, Carolina; Ortega Calvo, Jorge; Meana Martínez, José Javier; Sulzer, David (Biomed Central, 2014-07-29)
      Background: An accumulating body of evidence points to the significance of neuroinflammation and immunogenetics in schizophrenia, and an imbalance of cytokines in the central nervous system (CNS) has been suggested to be ...
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      D5 dopamine receptors control glutamatergic AMPA transmission between the motor cortex and subthalamic nucleus 

      Froux, Lionel; Le Bon-Jego, Morgane; Miguelez Palomo, Cristina; Normand, Elisabeth; Morin, Stephanie; Fioramonti, Stéphanie; Barresi, Massimo; Frick, Andreas; Baufreton, Jerome; Taupignon, Anne (Nature Publishing, 2018-06-11)
      Corticofugal fibers target the subthalamic nucleus (STN), a component nucleus of the basal ganglia, in addition to the striatum, their main input. The cortico-subthalamic, or hyperdirect, pathway, is thought to supplement ...
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      Depression of Serotonin Synaptic Transmission by the Dopamine Precursor L-DOPA 

      Gantz, Stephanie C.; Levitt, Erica S.; Llamosas Muñozguren, Nerea; Neve, Kim A.; Williams, John T. (Cell Press, 2015-08-11)
      Imbalance between the dopamine and serotonin (5-HT) neurotransmitter systems has been implicated in the comorbidity of Parkinson's disease (PD) and psychiatric disorders. L-DOPA, the leading treatment of PD, facilitates ...
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      Evaluation of Fentanyl Disposition and Effects in Newborn Piglets as an Experimental Model for Human Neonates 

      Rey Santano, María Carmen; Mielgo, Victoria; Valls Soler, Adolfo; Encinas Pérez, Esther; Lukas, John; Vozmediano, Valvanera; Suárez González, María Elena (Public Library Science, 2014-03-04)
      Background: Fentanyl is widely used off-label in NICU. Our aim was to investigate its cerebral, cardiovascular and pulmonary effects as well as pharmacokinetics in an experimental model for neonates. Methods: Fentanyl ...
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      Fast and Efficient Neural Conversion of Human Hematopoietic Cells 

      Castaño, Julio; Menéndez, Pablo; Bruzos Cidon, Cristina; Straccia, Marco; Sousa, Amaia; Zabaleta, Lorea; Vázquez, Nerea; Zubiarrain, Amaia; Sonntag, Kai-Christian; Ugedo Urruela, Luisa; Carvajal-Vergara, Xonia; Canals, Josep Maria; Torrecilla Sesma, Maria; Sánchez-Pernaute, Rosario; Giorgetti, Alessandra (Cell Press, 2014-12-09)
      Neurons obtained directly from human somatic cells hold great promise for disease modeling and drug screening. Available protocols rely on overexpression of transcription factors using integrative vectors and are often ...
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      GAT-3 Dysfunction Generates Tonic Inhibition in Exter nal Globus Pallidus Neurons in Parkinsonian Rodents 

      Chazalon, Marine; Paredes Rodríguez, Elena; Morin, Stéphanie; Martinez, Audrey; Cristóvão-Ferreira, Sofia; Vaz, Sandra; Sebastiao, Ana; Panatier, Aude; Boué-Grabot, Eric; Miguélez Palomo, Cristina; Baufreton, Jérôme (Cell Press, 2018-05-08)
      The external globus pallidus (GP) is a key GABAergic hub in the basal ganglia (BG) circuitry, a neuronal network involved in motor control. In Parkinson's disease (PD), the rate and pattern of activity of GP neurons are ...
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      Impairment of Serotonergic Transmission by the Antiparkinsonian Drug L-DOPA: Mechanisms and Clinical Implications 

      Miguélez Palomo, Cristina; Benazzouz, Abdelhamid; Ugedo Urruela, Luisa; De Deurwaerdère, Philippe (Frontiers Media, 2017-09-12)
      The link between the anti-Parkinsonian drug L-3,4-dihydroxyphenylalanine (L-DOPA) and the serotonergic (5-HT) system has been long established and has received increased attention during the last decade. Most studies have ...
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      Increased antiparkinson efficacy of the combined administration of VEGF- and GDNF-loaded nanospheres in a partial lesion model of Parkinson's disease 

      Herrán Martínez, Enara; Requejo Rodríguez, Catalina; Ruiz Ortega, José Ángel; Aristieta Arbelaiz, Asier; Igartua Olaechea, Manuela; Bengoetxea Odriozola, Harkaitz; Ugedo Urruela, Luisa; Pedraz Muñoz, José Luis; Lafuente Sánchez, José Vicente; Hernández Martín, Rosa María (Dove Medical Press, 2014)
      Current research efforts are focused on the application of growth factors, such as glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), as neuroregenerative approaches that will ...
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      Increased opioid dependence in a mouse model of panic disorder 

      Gallego, Xabier; Murtra, Patricia; Zamalloa Echevarría, Teresa; Canals, Josep Maria; Pineda Ortíz, Joseba Gotzon; Amador Arjona, Alejandro; Maldonado, Rafael; Dierssen, Mara (Frontiers Research Fundation, 2010-02-22)
      [EN] Panic disorder is a highly prevalent neuropsychiatric disorder that shows co-occurrence with substance abuse. Here, we demonstrate that TrkC, the high-affinity receptor for neurotrophin-3, is a key molecule involved ...
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      Interaction between the 5-HT system and the basal ganglia: functional implication and therapeutic perspective in Parkinson's disease 

      Miguélez Palomo, Cristina; Morera Herreras, Teresa; Torrecilla Sesma, María; Ruiz-Ortega, José Ángel; Ugedo Urruela, Luisa (Frontiers Research Foundation, 2014-03-17)
      The neurotransmitter serotonin (5-HT) has a multifaceted function in the modulation of information processing through the activation of multiple receptor families, including G-protein-coupled receptor subtypes (5-HT1, ...
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      Intracellular inflammatory and antioxidant pathways in postmortem frontal cortex of subjects with major depression: effect of antidepressants 

      Martín-Hernández, David; Caso, Javier R.; Meana Martínez, José Javier; Callado Hernando, Luis Felipe; Madrigal, José L. M.; García-Bueno, Borja; Leza, Juan Carlos (Biomed Central, 2018-09-04)
      Background: Studies show that Toll-like receptors (TLRs), members of the innate immune system, might participate in the pathogenesis of the major depressive disorder (MDD). However, evidence of this participation in the ...
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      Kv7 Channels Can Function without Constitutive Calmodulin Tethering 

      Gómez Posada, Juan Camilo; Aivar, Paloma; Alberdi González, Araitz; Alaimo Campi, Alessandro; Etxeberria, Ainhoa; Fernández-Orth, Juncal; Zamalloa Echevarría, Teresa; Roura-Ferrer, Meritxell; Villace Lozano, Patricia; Areso Goiricelaya, María Pilar; Casis Sáenz, Oscar; Villarroel Muñoz, Álvaro (Public Library of Science, 2011-09-28)
      M-channels are voltage-gated potassium channels composed of Kv7.2-7.5 subunits that serve as important regulators of neuronal excitability. Calmodulin binding is required for Kv7 channel function and mutations in Kv7.2 ...
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      Pivoting between Calmodulin Lobes Triggered by Calcium in the Kv7.2/Calmodulin Complex 

      Alaimo Campi, Alessandro; Alberdi González, Araitz; Gomis Pérez, Carolina; Fernández Orth, Juncal; Bernardo Seisdedos, Ganeko; Malo de la Fuente, Covadonga; Millet, Oscar; Areso Goiricelaya, María Pilar; Villarroel Muñoz, Álvaro (Public Library Science, 2014-01-28)
      Kv7.2 (KCNQ2) is the principal molecular component of the slow voltage gated M-channel, which strongly influences neuronal excitability. Calmodulin (CaM) binds to two intracellular C-terminal segments of Kv7.2 channels, ...
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      Postantifungal Effect of Micafungin against the Species Complexes of Candida albicans and Candida parapsilosis 

      Gil Alonso, Sandra; Jauregizar Albonigamayor, Nerea; Eraso Barrio, María Elena; Quindós Andrés, Guillermo (Public Library Science, 2015-07-13)
      Micafungin is an effective antifungal agent useful for the therapy of invasive candidiasis. Candida albicans is the most common cause of invasive candidiasis; however, infections due to non-C. albicans species, such as ...
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      Pretreatment with Resveratrol Prevents Neuronal Injury and Cognitive Deficits Induced by Perinatal Hypoxia-Ischemia in Rats 

      Arteaga Cabeza, Olatz; Revuelta Aramberri, Miren; Urigüen Echeverría, Leyre; Álvarez Díaz, Antonia Ángeles; Montalvo, Haizea; Hilario Rodríguez, Enrique (Public Library Science, 2015-11-06)
      Despite advances in neonatal care, hypoxic-ischemic brain injury is still a serious clinical problem, which is responsible for many cases of perinatal mortality, cerebral palsy, motor impairment and cognitive deficits. ...
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      Surface Expression and Subunit Specific Control of Steady Protein Levels by the Kv7.2 Helix A-B Linker 

      Aivar, Paloma; Fernández-Orth, Juncal; Gomis-Pérez, Carolina; Alberdi González, Araitz; Alaimo Campi, Alessandro; Rodríguez, Manuel S.; Giraldez, Teresa; Miranda, Pablo; Areso Goiricelaya, María Pilar; Villarroel Muñoz, Álvaro (Public Library of Science, 2013-10-24)
      Kv7.2 and Kv7.3 are the main components of the neuronal voltage-dependent M-current, which is a subthreshold potassium conductance that exerts an important control on neuronal excitability. Despite their predominantly ...