Now showing items 1-15 of 15

    • Thumbnail

      Altered glutamyl-aminopeptidase activity and expression in renal neoplasms 

      Blanco Criado, Lorena; Sanz Echevarría, María Begoña; Pérez Urzelai, Itxaro; Sánchez Fernández, Clara Eugenia; Cándenas, María Luz; Pinto, Francisco M.; Gil Goicouría, Francisco Javier; Casis Sáenz, Luis; López Fernández de Villaverde, José Ignacio; Larrinaga Embeita, Gorka (Biomed Central, 2014-05-30)
      Background: Advances in the knowledge of renal neoplasms have demonstrated the implication of several proteases in their genesis, growth and dissemination. Glutamyl-aminopeptidase (GAP) (EC. 3.4.11.7) is a zinc metallopeptidase ...
    • Thumbnail

      Collision tumour involving a rectal gastrointestinal stromal tumour with invasion of the prostate and a prostatic adenocarcinoma 

      Macías García, Laura; De la Hoz Herazo, Haydee; Robles Frías, Antonio; Pareja Megía, María J.; López Garrido, Juan; López Fernández de Villaverde, José Ignacio (BioMed Central, 2012)
      Background: Gastrointestinal stromal tumours (GISTs) are the most common primary mesenchymal neoplasia in the gastrointestinal tract, although they represent only a small fraction of total gastrointestinal malignancies ...
    • Thumbnail

      Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal 

      Turajlic, Samra; Xu, Hang; Litchfield, Kevin; Rowan, Andrew; Horswell, Stuart; Chambers, Tim; O'Brien, Tim; López Fernández de Villaverde, José Ignacio; Watkins, Thomas B. K.; Nicol, David; Stares, Mark; Challacombe, Ben; Hazell, Steve; Chandra, Ashish; Mitchell, Thomas J.; Au, Lewis; Eichler-Jonsson, Claudia; Jabbar, Faiz; Soultati, Aspasia; Chowdhury, Simon; Rudman, Sarah; Lynch, Joanna; Archana Sinduri, Fernando; Stamp, Gordon; Nye, Emma; Stewart, Aengus; Xing, Wei; Smith, Jonathan C.; Escudero, Mickael; Huffman, Adam; Matthews, Nik; Elgar, Greg; Phillimore, Ben; Costa, Marta; Begum, Sharmin; Ward, Sophia; Salm, Max; Boeing, Stefan; Fisher, Rosalie; Spain, Lavinia; Navas, Carolina; Gronroos, Eva; Hobor, Sebastijan; Sharma, Sarkhara; Aurangzeb, Ismaeel; Lall, Sharanpreet; Polson, Alexander; Varia, Mary; Horsfield, Catherine; Fotiadis, Nicos; Pickering, Lisa; Schwarz, Roland F.; Silva, Bruno; Herrero, Javier; Luscombe, Nick M.; Jamal-Hanjani, Mariam; Rosenthal, Rachel; Birkbak, Nicolai J.; Wilson, Gareth A.; Pipek, Orsolya; Ribli, Dezso; Krzystanek, Marcin; Csabai, Istvan; Szállási, Zoltán; Gore, Martin E.; McGranahan, Nicholas; Van Loo, Peter; Campbell, Peter; Larkin, James; Swanton, Charles (Cell Press, 2018-04-19)
      The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients recruited into the multi-center prospective study, ...
    • Thumbnail

      Dipeptidyl-Peptidase IV Activity Is Correlated with Colorectal Cancer Prognosis 

      Larrinaga Embeita, Gorka; Pérez Urzelai, Itxaro; Sanz Echevarría, María Begoña; Beitia San Vicente, Maider; Errarte Yarza, Peio; Fernández Atucha, Ainhoa; Blanco Criado, Lorena; Etxezarraga Zuluaga, María Carmen; Gil Goicouría, Francisco Javier; López Fernández de Villaverde, José Ignacio (Public Library Science, 2015-03-19)
      Background Dipeptidyl-peptidase IV (EC 3.4.14.5) (DPPIV) is a serine peptidase involved in cell differentiation, adhesion, immune modulation and apoptosis, functions that control neoplastic transformation. Previous ...
    • Thumbnail

      Dual-Specificity Phosphatases in Neuroblastoma Cell Growth and Differentiation 

      Nunes Xavier, Caroline E.; Zaldumbide Dueñas, Laura; Aurtenetxe, Olaia; López Almaraz, Ricardo; López Fernández de Villaverde, José Ignacio; Pulido, Rafael (MDPI, 2019-03-01)
      Dual-specificity phosphatases (DUSPs) are important regulators of neuronal cell growth and differentiation by targeting proteins essential to neuronal survival in signaling pathways, among which the MAP kinases (MAPKs) ...
    • Thumbnail

      Evidence of conditioned behavior in amoebae 

      Martínez de la Fuente Martínez, Ildefonso Abel; Bringas Roldán, Carlos; Malaina Celada, Iker; Fedetz, María; Carrasco Pujante, José; Morales, Miguel; Knafo Farhi, Dina Shira; Martínez Fernández, Luis; Pérez Samartín, Alberto Luis; López Fernández de Villaverde, José Ignacio; Pérez-Yarza Pérez-Irezabal, Gorka; Boyano López, María Dolores (Nature, 2019-08-15)
      Associative memory is the main type of learning by which complex organisms endowed with evolved nervous systems respond efficiently to certain environmental stimuli. It has been found in different multicellular species, ...
    • Thumbnail

      Expression and activity profiles of DPP IV/CD26 and NEP/CD10 glycoproteins in the human renal cancer are tumor-type dependent 

      Varona Gutiérrez, Adolfo; Blanco Criado, Lorena; Pérez Urcelai, Itxaro; Gil Goicouría, Francisco Javier; Irazusta Astiazaran, Jon; López Fernández de Villaverde, José Ignacio; Candenas, M. Luz; Pinto, Francisco M.; Larrinaga Embeita, Gorka (BioMed Central, 2010-05)
      Background: Cell-surface glycoproteins play critical roles in cell-to-cell recognition, signal transduction and regulation, thus being crucial in cell proliferation and cancer etiogenesis and development. DPP IV and NEP ...
    • Thumbnail

      Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness 

      Ruiz de Garibay, Gorka; Herranz, Carmen; Llorente, Alicia; Boni, Jacopo; Serra- Musach, Jordi; Mateo, Francesca; Aguilar, Helena; Gómez-Baldó, Laia; Petit, Anna; Vidal, August; Climent, Fina; Hernández-Losa, Javier; Cordero, Álex; González- Suárez, Eva; Sánchez-Mut, José Vicente; Esteller, Manel; Llatjós, Roger; Varela, Mar; López Fernández de Villaverde, José Ignacio; García, Nadia; Extremera, Ana I.; Gumà, Anna; Ortega, Raúl; Plà, María Jesús; Fernández, Adela; Pernas, Sònia; Falo, Catalina; Morilla, Idoia; Campos, Miriam; Gil, Miguel; Román, Antonio; Molina-Molina, María; Ussetti, Piedad; Laporta, Rosalía; Valenzuela, Claudia; Ancochea, Julio; Xaubet, Antoni; Casanova, Álvaro; Pujana, Miguel Angel (Public Library Science, 2015-07-07)
      Lymphangioleiomyomatosis (LAM) is a rare lung-metastasizing neoplasm caused by the proliferation of smooth muscle-like cells that commonly carry loss-of-function mutations in either the tuberous sclerosis complex 1 or 2 ...
    • Thumbnail

      Protein tyrosine phosphatase modulates cell growth and associates with poor outcome in human neuroblastoma 

      Nunes Xavier, Caroline E.; Aurtenetxe, Olaia; Zaldumbide Dueñas, Laura; López Almaraz, Ricardo; Erramuzpe Aliaga, Asier; Cortés Díaz, Jesús María; López Fernández de Villaverde, José Ignacio; Pulido, Rafael (BMC, 2019-12-14)
      Background Protein tyrosine phosphatases (PTPs) regulate neuronal differentiation and survival, but their expression patterns and functions in human neuroblastoma (NB) are scarcely known. Here, we have investigated the ...
    • Thumbnail

      The Expression of Fibroblast Activation Protein in Clear Cell Renal Cell Carcinomas Is Associated with Synchronous Lymph Node Metastases 

      Errarte Yarza, Peio; Guarch, Rosa; Pulido, Rafael; Blanco Criado, Lorena; Nunes Xavier, Caroline E.; Beitia San Vicente, Maider; Gil Goicuría, Francisco Javier; Angulo, Javier C.; López Fernández de Villaverde, José Ignacio (Public Library Science, 2016-12-29)
      Clear cell renal cell carcinoma (CCRCC) is a heterogeneous and complex disease that frequently develops distant metastases. Fibroblast activation protein (FAP) is a serine peptidase the expression of which in cancer-associated ...
    • Thumbnail

      The Impact of Tumor Eco-Evolution in Renal Cell Carcinoma Sampling 

      López Fernández, Estíbaliz; López Fernández de Villaverde, José Ignacio (MDPI, 2018-12-04)
      Malignant tumors behave dynamically as cell communities governed by ecological principles. Massive sequencing tools are unveiling the true dimension of the heterogeneity of these communities along their evolution in most ...
    • Thumbnail

      The Labyrinth of Renal Cell Carcinoma 

      Manini, Claudia; López Fernández de Villaverde, José Ignacio (MDPI, 2020-02-24)
      Renal cell carcinoma (RCC) ranks in the top-ten list of malignancies both in males and females [...]
    • Thumbnail

      Time resolved amplified FRET identifies protein kinase B activation state as a marker for poor prognosis in clear cell renal cell carcinoma 

      Miles, James; Applebee, Christopher J.; Leboucher, Pierre; López Fernández, Sonia; Lee, Dae-Jin; Guarch, Rosa; Ward, Stephen; Parker, Peter J.; López Fernández de Villaverde, José Ignacio; Larijani, Banafshé (Elsevier, 2017-12)
      Purpose: Clear cell Renal Cell Carcinomas (ccRCC), the largest group of renal tumours, are resistant to classical therapies. The determination of the functional state of actionable biomarkers for the assessment of these ...
    • Thumbnail

      Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal 

      TRACERx Renal Consortium; López Fernández de Villaverde, José Ignacio (Cell Press, 2018-04-19)
      Clear cell renal cell carcinoma (ccRCC) is characterized by near-universal loss of the short arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole genomes from 95 biopsies across 33 patients with ...
    • Thumbnail

      Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal 

      Turajlic, Samra; Xu, Hang; Litchfield, Kevin; Rowan, Andrew; Chambers, Tim; López Fernández de Villaverde, José Ignacio; Nicol, David; O'Brien, Tim; Larkin, James; Horswell, Stuart; Stares, Mark; Au, Lewis; Jamal-Hanjani, Mariam; Challacombe, Ben; Chandra, Ashish; Hazell, Steve; Eichler-Jonsson, Claudia; Soultati, Aspasia; Chowdhury, Simon; Rudman, Sarah; Lynch, Joanna; Archana Sinduri, Fernando; Stamp, Gordon; Nye, Emma; Jabbar, Faiz; Spain, Lavinia; Lall, Sharanpreet; Guarch, Rosa; Falzon, Mary; Proctor, Ian; Pickering, Lisa; Gore, Martin E.; Watkins, Thomas B. K.; Ward, Sophia; Stewart, Aengus; DiNatale, Renzo; Becerra, Maria F.; Reznik, Ed; Hsieh, James J.; Richmond, Todd A.; Mayhew, George F.; Hill, Samantha M.; McNally, Catherine D.; Jones, Carol; Rosenbaum, Heidi; Stanislaw, Stacey; Burgess, Daniel L.; Alexander, Nelson R.; Swanton, Charles (Cell Press, 2018-04-19)
      Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date. Here, we analyzed 575 primary and 335 metastatic biopsies across 100 patients with ...