BackBrowsing Artículos by Author "Lutz, Beat"
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Cannabinoid CB1 receptor gene inactivation in oligodendrocyte precursors disrupts oligodendrogenesis and myelination in mice
; ; ; ; ; ; ; ; Mato Santos, Susana
; ; ; ; (SpringerNature, 2022)
[EN] Cannabinoids are known to modulate oligodendrogenesis and developmental CNS myelination. However, the cell-autonomous action of these compounds on oligodendroglial cells in vivo, and the molecular mechanisms underlying ... -
Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior
Bilbao, Ainhoa; Neuhofer, Daniela; Sepers, Marja; Wei, Shou-peng; Eisenhardt, Manuela; Hertle, Sarah; Lassalle, Olivier; Ramos Uriarte, Almudena; Puente Bustinza, Nagore ; Lerner, Raissa; Thomazeau, Aurore; Grandes Moreno, Pedro Rolando ; Lutz, Beat; Manzoni, Olivier J.; Spanagel, Rainer (Cell Press, 2020-03-27)
The nucleus accumbens (NAc) plays a key role in drug-related behavior and natural reward learning. Synaptic plasticity in dopamine D1 and D2 receptor medium spiny neurons (MSNs) of the NAc and the endogenous cannabinoid ... -
Long-term hippocampal interneuronopathy drives sex-dimorphic spatial memory impairment induced by prenatal THC exposure
De Salas Quiroga, Adán; García Rincón, Daniel; Gómez Domínguez, Daniel; Valero, Manuel; Simón Sánchez, Samuel; Paraíso Luna, Juan; Aguareles, José; Pujadas, Mitona; Muguruza Millán, Carolina; Callado Hernando, Luis Felipe ; Lutz, Beat; Guzmán, Manuel; Menéndez de la Prida, Liset; Galve Roperh, Ismael (Nature, 2020-04)
Prenatal exposure to Delta(9)-tetrahydrocannabinol (THC), the most prominent active constituent of cannabis, alters neurodevelopmental plasticity with a long-term functional impact on adult offspring. Specifically, THC ... -
Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum
Moreno, Estefanía; Chiarlone, Anna; Medrano, Mireia; Puigdellivol, Mar; Bibic, Lucka; Howell, Lesley A.; Resel, Eva; Puente Bustinza, Nagore; Casarejos, Maria J.; Perucho, Juan; Botta, Joaquin; Suelves, Nuria; Ciruela, Francisco; Gines, Silvia; Galve Roperh, Ismael; Casado, Vicent; Grandes Moreno, Pedro Rolando ; Lutz, Beat; Monory, Krisztina; Canela, Enric I.; Lluis, Carmen; McCormick, Peter J.; Guzmán, Manuel (Nature Publishing Group, 2018-04)
The dorsal striatum is a key node for many neurobiological processes such as motor activity, cognitive functions, and affective processes. The proper functioning of striatal neurons relies critically on metabotropic ... -
Subsynaptic Distribution, Lipid Raft Targeting and G Protein-Dependent Signalling of the Type 1 Cannabinoid Receptor in Synaptosomes from the Mouse Hippocampus and Frontal Cortex
Saumell Esnaola, Miquel; Barrondo Lacarra, Sergio; ; Goicolea Altuna, María Aranzazu ; ; Lutz, Beat; Monory, Krisztina (MDPI, 2021-11-16)
Numerous studies have investigated the roles of the type 1 cannabinoid receptor (CB1) in glutamatergic and GABAergic neurons. Here, we used the cell-type-specific CB1 rescue model in mice to gain insight into the organizational ...