Browsing Artículos by Author "Martín Suárez, Soraya"

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      Alterations of the Hippocampal Neurogenic Niche in a Mouse Model of Dravet Syndrome 

      Martín Suárez, Soraya; Abiega Etxabe, Oihane; Ricobaraza, Ana; Hernández Alcoceba, Rubén; Encinas Pérez, Juan Manuel (Frontiers Media, 2020-07-21)
      Hippocampal neurogenesis, the process by which neural stem cells (NSCs) continuously generate new neurons in the dentate gyrus (DG) of most mammals including humans, is chiefly regulated by neuronal activity. Thus, severe ...
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      Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain 

      Schouten, Marijn; Bielefeld, Pascal; García Corzo, L.; Passchier, E. M. J.; Gradari, S.; Jungenitz, T.; Pons Espinal, M.; Gebara, E.; Martín Suárez, Soraya; Lucassen, Paul J.; De Vries, H. E.; Trejo Pérez, Jose Luis; Schwarzacher, S. W.; De Pietri Tonelli, D.; Toni, N.; Mira, H.; Encinas Pérez, Juan Manuel; Fitzsimons, Carlos P. (Springer, 2019-06-20)
      A decrease in adult hippocampal neurogenesis has been linked to age-related cognitive impairment. However, the mechanisms involved in this age-related reduction remain elusive. Glucocorticoid hormones (GC) are important ...
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      Lysophosphatidic Acid Receptor 1 Specifically Labels Seizure-Induced Hippocampal Reactive Neural Stem Cells and Regulates Their Division 

      Valcárcel Martín, Roberto ORCID; Martín Suárez, Soraya; Muro García, Teresa; Pastor Alonso, Oier; Rodríguez de Fonseca, Fernando; Estivill Torrús, Guillermo; Encinas Pérez, Juan Manuel (Frontiers Media, 2020-08-14)
      A population of neural stem cells (NSCs) dwelling in the dentate gyrus (DG) is able to generate neurons throughout adult life in the hippocampus of most mammals. These NSCs generate also astrocytes naturally and are capable ...
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      Neuropathological Characterization of a Dravet Syndrome Knock-In Mouse Model Useful for Investigating Cannabinoid Treatments 

      Satta, Valentina; Alonso, Cristina; Díez, Paula; Martín Suárez, Soraya; Rubio, Marta; Encinas Pérez, Juan Manuel; Fernández Ruiz, Javier; Sagredo Ezkioga, Onintza (Frontiers Media, 2021-01-29)
      Dravet syndrome (DS) is an epileptic syndrome caused by mutations in the Scn1a gene encoding the alpha 1 subunit of the sodium channel Nav1.1, which is associated with febrile seizures that progress to severe tonic-clonic ...
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      Phenotypical and functional heterogeneity of neural stem cells in the aged hippocampus 

      Martín Suárez, Soraya; Valero Gómez-Lobo, Jorge; Muro García, Teresa; Encinas Pérez, Juan Manuel (Wiley, 2019-08)
      Adult neurogenesis persists in the hippocampus of most mammal species during postnatal and adult life, including humans, although it declines markedly with age. The mechanisms driving the age-dependent decline of hippocampal ...
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      Reactive Disruption of the Hippocampal Neurogenic Niche After Induction of Seizures by Injection of Kainic Acid in the Amygdala 

      Muro García, Teresa; Martín Suárez, Soraya; Espinosa, Nelson; Valcárcel Martín, Roberto ORCID; Marinas, Ainhoa; Zaldumbide Dueñas, Laura; Galbarriatu, Lara; Sierra Saavedra, Amanda; Fuentealba, Pablo; Encinas Pérez, Juan Manuel (Frontiers Media, 2019-08-20)
      Adult neurogenesis persists in the adult hippocampus due to the presence of multipotent neural stem cells (NSCs). Hippocampal neurogenesis is involved in a range of cognitive functions and is tightly regulated by neuronal ...