Now showing items 1-14 of 14

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      Collision tumour involving a rectal gastrointestinal stromal tumour with invasion of the prostate and a prostatic adenocarcinoma 

      Macías García, Laura; De la Hoz Herazo, Haydee; Robles Frías, Antonio; Pareja Megía, María J.; López Garrido, Juan; López Fernández de Villaverde, José Ignacio (BioMed Central, 2012)
      Background: Gastrointestinal stromal tumours (GISTs) are the most common primary mesenchymal neoplasia in the gastrointestinal tract, although they represent only a small fraction of total gastrointestinal malignancies ...
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      Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal 

      Turajlic, Samra; Xu, Hang; Litchfield, Kevin; Rowan, Andrew; Horswell, Stuart; Chambers, Tim; O'Brien, Tim; López Fernández de Villaverde, José Ignacio; Watkins, Thomas B. K.; Nicol, David; Stares, Mark; Challacombe, Ben; Hazell, Steve; Chandra, Ashish; Mitchell, Thomas J.; Au, Lewis; Eichler-Jonsson, Claudia; Jabbar, Faiz; Soultati, Aspasia; Chowdhury, Simon; Rudman, Sarah; Lynch, Joanna; Archana Sinduri, Fernando; Stamp, Gordon; Nye, Emma; Stewart, Aengus; Xing, Wei; Smith, Jonathan C.; Escudero, Mickael; Huffman, Adam; Matthews, Nik; Elgar, Greg; Phillimore, Ben; Costa, Marta; Begum, Sharmin; Ward, Sophia; Salm, Max; Boeing, Stefan; Fisher, Rosalie; Spain, Lavinia; Navas, Carolina; Gronroos, Eva; Hobor, Sebastijan; Sharma, Sarkhara; Aurangzeb, Ismaeel; Lall, Sharanpreet; Polson, Alexander; Varia, Mary; Horsfield, Catherine; Fotiadis, Nicos; Pickering, Lisa; Schwarz, Roland F.; Silva, Bruno; Herrero, Javier; Luscombe, Nick M.; Jamal-Hanjani, Mariam; Rosenthal, Rachel; Birkbak, Nicolai J.; Wilson, Gareth A.; Pipek, Orsolya; Ribli, Dezso; Krzystanek, Marcin; Csabai, Istvan; Szállási, Zoltán; Gore, Martin E.; McGranahan, Nicholas; Van Loo, Peter; Campbell, Peter; Larkin, James; Swanton, Charles (Cell Press, 2018-04-19)
      The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients recruited into the multi-center prospective study, ...
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      Dipeptidyl-Peptidase IV Activity Is Correlated with Colorectal Cancer Prognosis 

      Larrinaga Embeita, Gorka; Pérez Urzelai, Itxaro; Sanz Echevarría, María Begoña; Beitia San Vicente, Maider; Errarte Yarza, Peio; Fernández Atucha, Ainhoa; Blanco Criado, Lorena; Etxezarraga Zuloaga, María Carmen; Gil Goicouría, Francisco Javier; López Fernández de Villaverde, José Ignacio (Public Library Science, 2015-03-19)
      Background Dipeptidyl-peptidase IV (EC 3.4.14.5) (DPPIV) is a serine peptidase involved in cell differentiation, adhesion, immune modulation and apoptosis, functions that control neoplastic transformation. Previous ...
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      Dual-Specificity Phosphatases in Neuroblastoma Cell Growth and Differentiation 

      Nunes Xavier, Caroline E.; Zaldumbide Dueñas, Laura; Aurtenetxe, Olaia; López Almaraz, Ricardo; López Fernández de Villaverde, José Ignacio; Pulido, Rafael (MDPI, 2019-03-01)
      Dual-specificity phosphatases (DUSPs) are important regulators of neuronal cell growth and differentiation by targeting proteins essential to neuronal survival in signaling pathways, among which the MAP kinases (MAPKs) ...
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      Estimation of preterm labor immediacy by nonlinear methods 

      Malaina Celada, Iker; Martínez Fernández, Luis; Matorras Weinig, José Roberto; Bringas Roldán, Carlos; Aranburu Laka, Larraitz; Fernández-Llebrez del Rey, Luis; González, Leire; Arana, Itziar; Pérez Pinilla, Martín Blas; Martínez de la Fuente Martínez, Ildefonso Abel (Public Library Science, 2017-06-01)
      Preterm delivery affects about one tenth of human births and is associated with an increased perinatal morbimortality as well as with remarkable costs. Even if there are a number of predictors and markers of preterm delivery, ...
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      Gene Expression Study and Pathway Analysis of Histological Subtypes of Intestinal Metaplasia that Progress to Gastric Cancer 

      Companioni, Osmel; Sanz Anquela, José Miguel; Pardo López, María Luisa; Puigdecanet Riubugent, Eulàlia; Nonell Mazelón, Lara; García, Nadia; Parra Blanco, Verónica; López, Consuelo; Andreu, Victoria; Cuatrecasas, Miriam; Garmendia Irizar, Maddi; Gisbert, Javier P.; González, Carlos A.; Sala, Núria (Public Library Science, 2017-04-25)
      Background Intestinal metaplasia (IM) is a precursor lesion that precedes gastric cancer (GC). There are two IM histological subtypes, complete (CIM) and incomplete (IIM), the latter having higher progression rates to ...
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      Human Papillomavirus (HPV) genotype 18 variants in patients with clinical manifestations of HPV related infections in Bilbao, Spain 

      Arroyo, Sara L.; Basaras Ibarzabal, Miren; Arrese Arratibel, Miren Elixabete; Hernáez, Silvia; Andia Ortiz, Daniel; Esteban, Valetín; García Etxebarria, Koldo; Jugo Orrantia, Begoña Marina; Cisterna Cáncer, Ramón (BioMed Central, 2012)
      Background:Human papillomavirus (HPV) variants differ in their biological and chemical properties, and therefore, may present differences in pathogenicity. Most authors classified variants based on the phylogenetic analysis ...
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      Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness 

      Ruiz de Garibay, Gorka; Herranz, Carmen; Llorente, Alicia; Boni, Jacopo; Serra- Musach, Jordi; Mateo, Francesca; Aguilar, Helena; Gómez-Baldó, Laia; Petit, Anna; Vidal, August; Climent, Fina; Hernández-Losa, Javier; Cordero, Álex; González- Suárez, Eva; Sánchez-Mut, José Vicente; Esteller, Manel; Llatjós, Roger; Varela, Mar; López Fernández de Villaverde, José Ignacio; García, Nadia; Extremera, Ana I.; Gumà, Anna; Ortega, Raúl; Plà, María Jesús; Fernández, Adela; Pernas, Sònia; Falo, Catalina; Morilla, Idoia; Campos, Miriam; Gil, Miguel; Román, Antonio; Molina-Molina, María; Ussetti, Piedad; Laporta, Rosalía; Valenzuela, Claudia; Ancochea, Julio; Xaubet, Antoni; Casanova, Álvaro; Pujana, Miguel Angel (Public Library Science, 2015-07-07)
      Lymphangioleiomyomatosis (LAM) is a rare lung-metastasizing neoplasm caused by the proliferation of smooth muscle-like cells that commonly carry loss-of-function mutations in either the tuberous sclerosis complex 1 or 2 ...
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      Micrornas Expression Profile in Solid and Unicystic Ameloblastomas 

      Setién Olarra, Amaia; Marichalar Mendia, Xabier; García Bediaga, Naiara; Aguirre Echebarria, Pablo; Aguirre Urizar, José Manuel; Mosqueda Taylor, Adalberto (Public Library Science, 2017-10-20)
      Objectives Odontogenic tumors (OT) represent a specific pathological category that includes some lesions with unpredictable biological behavior. Although most of these lesions are benign, some, such as the ameloblastoma, ...
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      Study of the Genetic Etiology of Primary Ovarian Insufficiency: FMR1 Gene 

      Barasoain Hernandez, Maitane; Barrenetxea Ziarrusta, Gorka; Huerta, Iratxe; Télez, Mercedes; Criado, Begoña; Arrieta Saez, María Isabel (MDPI, 2016-12-13)
      Menopause is a period of women's life characterized by the cessation of menses in a definitive way. The mean age for menopause is approximately 51 years. Primary ovarian insufficiency (POI) refers to ovarian dysfunction ...
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      The Impact of Tumor Eco-Evolution in Renal Cell Carcinoma Sampling 

      López Fernández, Estíbaliz; López Fernández de Villaverde, José Ignacio (MDPI, 2018-12-04)
      Malignant tumors behave dynamically as cell communities governed by ecological principles. Massive sequencing tools are unveiling the true dimension of the heterogeneity of these communities along their evolution in most ...
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      Time resolved amplified FRET identifies protein kinase B activation state as a marker for poor prognosis in clear cell renal cell carcinoma 

      Miles, James; Applebee, Christopher J.; Leboucher, Pierre; López Fernández, Sonia; Lee, Dae-Jin; Guarch, Rosa; Ward, Stephen; Parker, Peter J.; López Fernández de Villaverde, José Ignacio; Larijani, Banafshé (Elsevier, 2017-12)
      Purpose: Clear cell Renal Cell Carcinomas (ccRCC), the largest group of renal tumours, are resistant to classical therapies. The determination of the functional state of actionable biomarkers for the assessment of these ...
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      Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal 

      TRACERx Renal Consortium; López Fernández de Villaverde, José Ignacio (Cell Press, 2018-04-19)
      Clear cell renal cell carcinoma (ccRCC) is characterized by near-universal loss of the short arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole genomes from 95 biopsies across 33 patients with ...
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      Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal 

      Turajlic, Samra; Xu, Hang; Litchfield, Kevin; Rowan, Andrew; Chambers, Tim; López Fernández de Villaverde, José Ignacio; Nicol, David; O'Brien, Tim; Larkin, James; Horswell, Stuart; Stares, Mark; Au, Lewis; Jamal-Hanjani, Mariam; Challacombe, Ben; Chandra, Ashish; Hazell, Steve; Eichler-Jonsson, Claudia; Soultati, Aspasia; Chowdhury, Simon; Rudman, Sarah; Lynch, Joanna; Archana Sinduri, Fernando; Stamp, Gordon; Nye, Emma; Jabbar, Faiz; Spain, Lavinia; Lall, Sharanpreet; Guarch, Rosa; Falzon, Mary; Proctor, Ian; Pickering, Lisa; Gore, Martin E.; Watkins, Thomas B. K.; Ward, Sophia; Stewart, Aengus; DiNatale, Renzo; Becerra, Maria F.; Reznik, Ed; Hsieh, James J.; Richmond, Todd A.; Mayhew, George F.; Hill, Samantha M.; McNally, Catherine D.; Jones, Carol; Rosenbaum, Heidi; Stanislaw, Stacey; Burgess, Daniel L.; Alexander, Nelson R.; Swanton, Charles (Cell Press, 2018-04-19)
      Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date. Here, we analyzed 575 primary and 335 metastatic biopsies across 100 patients with ...