Browsing Artículos by Author "Overkleeft, Herman S."
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Synthetic Zwitterionic Streptococcus pneumoniae Type 1 Oligosaccharides Carrying Labile O-Acetyl Esters
Wang, Zhen; Gimeno, Ana; Gutiérrez Lete, Marta; Overkleeft, Herman S.; Van der Marel, Gijsbert A.; Chiodo, Fabrizio; Jiménez Barbero, Jesús ; Codee, Jeroen D. C. (Wiley, 2023-01)We herein report the first total synthesis of the Streptococcus pneumoniae serotype 1 (Sp1) oligosaccharide, a unique zwitterionic capsular polysaccharide carrying labile O-acetyl esters. The target oligosaccharides, ... -
Synthetic, Zwitterionic Sp1 Oligosaccharides Adopt a Helical Structure Crucial for Antibody Interaction
Zhang, Qingju; Gimeno, Ana; Santana, Darielys; Wang, Zhen; Valdés Balbín, Yury; Rodríguez Noda, Laura M.; Hansen, Thomas; Kong, Li; Shen, Mengjie; Overkleeft, Herman S.; Verez Bencomo, Vicente; Van der Marel, Gijsbert A.; Jiménez Barbero, Jesús ; Chiodo, Fabrizio; Codee, Jeroen D. C. (American Chemical Society, 2019-08-28)The zwitterionic Streptococcus pneumoniae serotype 1 polysaccharide (Sp1) is an important anchor point for our immune system to act against streptococcal infections. Antibodies can recognize Sp1 saccharides, and it has ...