Browsing Artículos by Author "Rodríguez Arellano, José Julio"
Now showing items 1-7 of 7
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Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model : mechanism for deficient glutamatergic transmission?
Olabarria, Markel; Noristani, Harun N.; Verkhratsky, Alexei; Rodríguez Arellano, José Julio (BioMed Central, 2011-07-30)Astrocytes are fundamental for brain homeostasis and the progression and outcome of many neuropathologies including Alzheimer's disease (AD). In the triple transgenic mouse model of AD (3xTg-AD) generalised hippocampal ... -
Disruption of Oligodendrocyte Progenitor Cells is an Early Sign of Pathology in the Triple Transgenic Mouse Model of Alzheimer's Disease
Vanzulli, Ilaria; Papanikolaou, Maria; Chacón de la Rocha, Irene; Pieropan, Francesca; Rivera, Andrea D.; Gómez Nicola, Diego; Verkhratsky, Alexei; Rodríguez Arellano, José Julio; Butt, Arthur M. (Elsevier, 2020-10)There is increasing evidence that myelin disruption is related to cognitive decline in Alzheimer's disease (AD). In the CNS, myelin is produced by oligodendrocytes, which are generated throughout life by adult oligodendrocyte ... -
Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer's disease
Yeh, Chia-Yu; Vadhwana, Bhamini; Verkhratsky, Alexei; Rodríguez Arellano, José Julio (Portland Press, 2011)The EC (entorhinal cortex) is fundamental for cognitive and mnesic functions. Thus damage to this area appears as a key element in the progression of AD (Alzheimer's disease), resulting in memory deficits arising from ... -
Effects of Cannabidiol, Hypothermia, and Their Combination in Newborn Rats with Hypoxic-Ischemic Encephalopathy
Álvarez Díaz, Francisco José; Álvarez Díaz, Antonia Ángeles; Rodríguez Arellano, José Julio; Lafuente, Héctor; Canduela Pérez, Miren Josune; Hind, William; Blanco Bruned, José Luis; Alonso Alconada, Daniel ; Hilario Rodríguez, Enrique (Society for Neuroscience, 2023-04)Therapeutic hypothermia is well established as a standard treatment for infants with hypoxic-ischemic (HI) encephalopathy but it is only partially effective. The potential for combination treatments to augment hypothermic ... -
GFAP Isoforms in Adult Mouse Brain with a Focus on Neurogenic Astrocytes and Reactive Astrogliosis in Mouse Models of Alzheimer Disease
Kamphuis, Willem; Mamber, Carlyn; Moeton, Martina; Kooijman, Lieneke; Sluijs, Jacqueline A.; Jansen, Anne H. P.; Verveer, Monique; De Groot, Lody R.; Smith, Vanessa D.; Rangarajan, Sindhoo; Rodríguez Arellano, José Julio; Orre, Marie; Hol, Elly M. (Public Library of Science, 2012-08-13)Glial fibrillary acidic protein (GFAP) is the main astrocytic intermediate filament (IF). GFAP splice isoforms show differential expression patterns in the human brain. GFAPδ is preferentially expressed by neurogenic ... -
Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer's disease
Rodríguez Arellano, José Julio; Witton, J.; Olabarria, M.; Noristani, H.N.; Verkhratsky, Alexei (Nature Publishing Group, 2010-01)The formation of cerebral senile plaques composed of amyloid beta peptide (A beta) is a fundamental feature of Alzheimer's disease (AD). Glial cells and more specifically microglia become reactive in the presence of A beta. ... -
Increased Calcium-Sensing Receptor Immunoreactivity in the Hippocampus of a Triple Transgenic Mouse Model of Alzheimer's Disease
Gardenal, Emanuela; Chiarini, Anna; Armato, Ubaldo; Dal Prà, Ilaria; Verkhratsky, Alexei; Rodríguez Arellano, José Julio (Frontiers Media, 2017-02-16)The Calcium-Sensing Receptor (CaSR) is a G-protein coupled, 7-transmembrane domain receptor ubiquitously expressed throughout the body, brain including. The role of CaSR in the CNS is not well understood; its expression ...