BackBrowsing Artículos by Author "Rodríguez Arrondo, José Luis"
Now showing items 1-6 of 6
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Cholesterol Constrains the Antigenic Configuration of the Membrane-Proximal Neutralizing HIV-1 Epitope
Torralba Iturbe, Johana
; De la Arada Echevarría, Igor ; ; ; ; ; ; ; Apellaniz Unzalu, Beatriz ; (ACS, 2020-06-25)
The envelope glycoprotein (Env) enables HIV-1 cell entry through fusion of host-cell and viral membranes induced by the transmembrane subunit gp41. Antibodies targeting the C-terminal sequence of the membrane-proximal ... -
Conformational Plasticity Underlies Membrane Fusion Induced by an HIV Sequence Juxtaposed to the Lipid Envelope
De la Arada Echevarría, Igor; Torralba Iturbe, Johana ; ; ; Ubarrechena Belandia, Iván ; ; Apellaniz Unzalu, Beatriz ; (Springer Nature, 2021-01-14)
Envelope glycoproteins from genetically-divergent virus families comprise fusion peptides (FPs) that have been posited to insert and perturb the membranes of target cells upon activation of the virus-cell fusion reaction. ... -
Exploring Polar Headgroup Interactions Between Sphingomyelin and Ceramide with Infrared Spectroscopy
De la Arada Echevarría, Igor; ; Alonso Izquierdo, Alicia ; Goñi Urcelay, Félix María ; Rodríguez Arrondo, José Luis (Nature, 2020-10-19)
Ceramide is a major actor in the sphingolipid signaling pathway elicited by various kinds of cell stress. Under those conditions ceramide (Cer) is produced in the plasma membrane as a product of sphingomyelin (SM) hydrolysis, ... -
Human LDL Structural Diversity Studied by IR Spectroscopy
(Public Library Science, 2014-03-18)Lipoproteins are responsible for cholesterol traffic in humans. Low density lipoprotein (LDL) delivers cholesterol from liver to peripheral tissues. A misleading delivery can lead to the formation of atherosclerotic plaques. ... -
Phosphorylation of the carboxy-terminal domain of histone H1: effects on secondary structure and DNA condensation
(Oxford University Press, 2008-08)Linker histone H1 plays an important role in chromatin folding. Phosphorylation by cyclin-dependent kinases is the main post-translational modification of histone H1. We studied the effects of phosphorylation on the secondary ... -
The Binding of Aβ42 Peptide Monomers to Sphingomyelin/Cholesterol/Ganglioside Bilayers Assayed by Density Gradient Ultracentrifugation
; De la Arada Echevarría, Igor; Masserini, Massimo E.; Rodríguez Arrondo, José Luis; Goñi Urcelay, Félix María ; Alonso Izquierdo, Alicia (MDPI, 2020-02-29)
The binding of Aβ42 peptide monomers to sphingomyelin/cholesterol (1:1 mol ratio) bilayers containing 5 mol% gangliosides (either GM1, or GT1b, or a mixture of brain gangliosides) has been assayed by density gradient ...