BackBrowsing Artículos by Author "Rodríguez-Antigüedad Zarranz, Alfredo"
Now showing items 1-14 of 14
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A functional variant that affects exon-skipping and protein expression of SP140 as genetic mechanism predisposing to multiple sclerosis
(Oxford University Pres, 2015-10-01)Several variants in strong linkage disequilibrium (LD) at the SP140 locus have been associated with multiple sclerosis (MS), Crohn's disease (CD) and chronic lymphocytic leukemia (CLL). To determine the causal polymorphism, ... -
An Overground Robotic Gait Training Program for People With Multiple Sclerosis: A Protocol for a Randomized Clinical Trial
Berriozabalgoitia, Rakel
; ; ; ; Yeregui Prieto, Izaskun ; ; Duñabeitia Usategui, Iratxe ; ; Domercq García, María ; Irazusta Astiazaran, Jon ; (Frontiers Media, 2020)
Maintaining the ability to walk is one of the significant challenges in people with multiple sclerosis (MS) for keeping a good quality of life as the disease and the aging process progresses. Overground robotic (OR) wearable ... -
Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients
(Genetics Society of America, 2016-07-01)Multiple sclerosis (MS) is a prevalent neurological disease of complex etiology. Here, we describe the characterization of a multi-incident MS family that nominated a rare missense variant (p.G420D) in plasminogen (PLG) ... -
Assessing care-related regret among nurses specialized in multiple sclerosis: A psychometric analysis of a new assessment battery
Ballesteros Rodríguez, Francisco Javier; ; ; ; ; ; ; ; (SAGE, 2022-10)
Experiences of regret associated with caring for patients with multiple sclerosis (MS) can affect medical decisions. A non-interventional study was conducted to assess the dimensionality and item characteristics of a battery ... -
Autoimmune inflammation triggers aberrant astrocytic calcium signaling to impair synaptic plasticity
; ; ; ; ; ; ; Soria Gómez, Edgar; ; ; ; ; Mato Santos, Susana (Elsevier, 2024-10)
Cortical pathology involving inflammatory and neurodegenerative mechanisms is a hallmark of multiple sclerosis and a correlate of disease progression and cognitive decline. Astrocytes play a pivotal role in multiple sclerosis ... -
Autophagic Marker MAP1LC3B Expression Levels Are Associated with Carotid Atherosclerosis Symptomatology
(Public Library Science, 2014-12-12)Objectives: The mechanism by which atheroma plaque becomes unstable is not completely understood to date but analysis of differentially expressed genes in stable versus unstable plaques may provide clues. This will be ... -
Effects of FTY720 on brain neurogenic niches in vitro and after kainic acid-induced injury
Cipriani, Raffaela; ; ; (Biomed Central, 2017-07-24)
Background: FTY720 (fingolimod, Gilenya (TM)) is an oral, blood-brain barrier (BBB)-passing drug approved as immunomodulatory treatment for relapsing-remitting form of the multiple sclerosis (MS). In addition, FTY720 exerts ... -
Exome sequencing in multiple sclerosis families identifies 12 candidate genes and nominates biological pathways for the genesis of disease
(Public Library Science 15(6) : (2019) // Article ID e1008180, 2019-06-06)Multiple sclerosis (MS) is an inflammatory disease of the central nervous system characterized by myelin loss and neuronal dysfunction. Although the majority of patients do not present familial aggregation, Mendelian forms ... -
Fine mapping and functional analysis of the multiple sclerosis risk gene CD6
(Public Library of Science, 2013)CD6 has recently been identified and validated as risk gene for multiple sclerosis (MS), based on the association of a single nucleotide polymorphism (SNP), rs17824933, located in intron 1. CD6 is a cell surface scavenger ... -
FTY720 attenuates excitotoxicity and neuroinflammation
Cipriani, Raffaela; Chara Ventura, Juan Carlos; Rodríguez-Antigüedad Zarranz, Alfredo; (BioMed Central, 2015-05-08)
Background: FTY720 (fingolimod, Gilenya(TM)), a structural analog of sphingosine-1-phosphate (S1P), is the first oral drug approved for treatment the relapsing-remitting form of multiple sclerosis (MS), and its efficacy ... -
Gene Expression Analysis of Astrocyte and Microglia Endocannabinoid Signaling during Autoimmune Demyelination
Moreno García, Álvaro; ; Colomer, Teresa; Rodríguez-Antigüedad Zarranz, Alfredo; ; Mato Santos, Susana (MDPI, 2020-08-24)
The endocannabinoid system is associated with protective effects in multiple sclerosis (MS) that involve attenuated innate immune cell responses. Astrocytes and microglia are modulated by endocannabinoids and participate ... -
Human Endogenous Retrovirus HERV-Fc1 Association with Multiple Sclerosis Susceptibility: A Meta-Analysis
(Public Library Science, 2014-03-03)Background: Human endogenous retroviruses (HERVs) are repetitive sequences derived from ancestral germ-line infections by exogenous retroviruses and different HERV families have been integrated in the genome. HERV-Fc1 in ... -
Increased expression of cystine/glutamate antiporter in multiple sclerosis
Pampliega Ormaetxea, Olatz; Domercq García, María ; Soria Lannes, Federico Nicolás ; ; ; (BioMed Central, 2011-06-03)
Background: Glutamate excitotoxicity contributes to oligodendrocyte and tissue damage in multiple sclerosis (MS). Intriguingly, glutamate level in plasma and cerebrospinal fluid of MS patients is elevated, a feature which ... -
Regret and therapeutic decisions in multiple sclerosis care: literature review and research protocol
; ; ; ; ; ; ; Ballesteros Rodríguez, Francisco Javier; (Frontiers Media, 2021-06-21)
[EN] Background: Decisions based on erroneous assessments may result in unrealistic patient and family expectations, suboptimal advice, incorrect treatment, or costlymedical errors. Regret is a common emotion in daily ...