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Targeting mTOR as a Therapeutic Approach in Medulloblastoma
(MDPI, 2018-07)
Mechanistic target of rapamycin (mTOR) is a master signaling pathway that regulates organismal growth and homeostasis, because of its implication in protein and lipid synthesis, and in the control of the cell cycle and the ...
Sensorized Tip for Monitoring People with Multiple Sclerosis that Require Assistive Devices for Walking
(MDPI, 2020-08-03)
Multiple Sclerosis (MS) is a neurological degenerative disease with high impact on our society. In order to mitigate its effects, proper rehabilitation therapy is mandatory, in which individualisation is a key factor. ...
Wnt-3a Induces Epigenetic Remodeling in Human Dental Pulp Stem Cells
(MDPI, 2020-03-07)
Dental pulp stem cells (DPSCs) from adult teeth show the expression of a very complete repertoire of stem pluripotency core factors and a high plasticity for cell reprogramming. Canonical Wnt and Notch signaling pathways ...
A preliminary analysis of gait performance of patients with multiple sclerosis using a sensorized crutch tip
(Elsevier, 2020-07-17)
The quality of life and functional mobility of patients with Multiple Sclerosis (MS) can significantly improve with exercise and a rehabilitation therapy adjusted to the needs of each patient. The assessment of gait and ...
Autocrine regulation of human sperm motility by tachykinins
(BioMed Central, 2010)
Background
We examined the presence and function of tachykinins and the tachykinin-degrading enzymes neprilysin (NEP) and neprilysin-2 (NEP2) in human spermatozoa.
Methods
Freshly ejaculated semen was collected from ...
The Voltage-Gated Sodium Channel Na(v)1.8 Is Expressed in Human Sperm
(Public Library of Science, 2013-09)
The role of Na+ fluxes through voltage-gated sodium channels in the regulation of sperm cell function remains poorly understood. Previously, we reported that several genes encoding voltage-gated Na+ channels were expressed ...
Morphine leads to global genome changes in H3K27me3 levels via a Polycomb Repressive Complex 2 (PRC2) self-regulatory mechanism in mESCs
(BioMed Central, 2020-11-09)
Background: Environmentally induced epigenetic changes can lead to health problems or disease, but the mechanisms involved remain unclear. Morphine can pass through the placental barrier leading to abnormal embryo development. ...
High Thyrotropin Is Critical for Cardiac Electrical Remodeling and Arrhythmia Vulnerability in Hypothyroidism
(Mary Ann Liebert, 2019-07-17)
Background: Hypothyroidism, the most common endocrine disease, induces cardiac electrical remodeling that creates a substrate for ventricular arrhythmias. Recent studies report that high thyrotropin (TSH) levels are related ...
Effects of Leucine-Enriched Whey Protein Supplementation on Physical Function in Post-Hospitalized Older Adults Participating in 12-Weeks of Resistance Training Program: A Randomized Controlled Trial
(MDPI, 2019-10-01)
Age-related strength and muscle mass loss is further increased after acute periods of inactivity. To avoid this, resistance training has been proposed as an effective countermeasure, but the additional effect of a protein ...
The Crossroad of Ion Channels and Calmodulin in Disease
(MDPI, 2019-01-02)
Calmodulin (CaM) is the principal Ca2+ sensor in eukaryotic cells, orchestrating the activity of hundreds of proteins. Disease causing mutations at any of the three genes that encode identical CaM proteins lead to major ...