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Computational and Experimental Evaluation of the Immune Response of Neoantigens for Personalized Vaccine Design
(MDPI, 2023-05-19)
In the last few years, the importance of neoantigens in the development of personalized antitumor vaccines has increased remarkably. In order to study whether bioinformatic tools are effective in detecting neoantigens that ...
Stem Cell Therapy and Rejuvenation, and Their Impact on Society
(MDPI, 2023-06-07)
n his worldwide best-seller Homo Deus [1], historian and philosopher Yuval Noah Harari discusses the future challenges facing humankind. In particular, he predicts that humanity will pursue three goals in the coming decades: ...
Self-assembled three-dimensional hydrogels based on graphene derivatives and cerium oxide nanoparticles: scaffolds for co-culture of oligodendrocytes and neurons derived from neural stem cells
(American Chemical Society, 2023-03)
Stem cell-based therapies have shown promising results for the regeneration of the nervous system. However, the survival and integration of the stem cells in the neural circuitry is suboptimal and might compromise the ...
The domestic dog that lived ∼17,000 years ago in the Lower Magdalenian of Erralla site (Basque Country): A radiometric and genetic analysis
(Elsevier, 2022-12)
Dogs are known to be the first species domesticated by humans, although the geographic and temporal origin of this process is still under debate in different fields of knowledge. In the present study, we examined a humerus ...
BRAF V600E mutational load as a prognosis biomarker in malignant melanoma
(Public Library Science, 2020-03-13)
Analyzing the mutational load of driver mutations in melanoma could provide valuable information regarding its progression. We aimed at analyzing the heterogeneity of mutational load of BRAF V600E in biopsies of melanoma ...
RKIP Regulates Differentiation-Related Features in Melanocytic Cells
(MDPI, 2020-06-03)
Raf Kinase Inhibitor Protein (RKIP) has been extensively reported as an inhibitor of keysignaling pathways involved in the aggressive tumor phenotype and shows decreased expressionin several types of cancers. However, ...
Serum markers improve current prediction of metastasis development in early-stage melanoma patients: a machine learning-based study
(Wiley, 2020-06)
Metastasis development represents an important threat for melanoma patients, even when diagnosed at early stages and upon removal of the primary tumor. In this scenario, determination of prognostic biomarkers would be of ...
Intermitochondrial cement (IMC) harbors piRNA biogenesis machinery and exonuclease domain-containing proteins EXD1 and EXD2 in mouse spermatocytes
(Wiley, 2023-05)
Background
Germ granules are large cytoplasmic ribonucleoprotein complexes that emerge in the germline to participate in RNA regulation. The two most prominent germ granules are the intermitochondrial cement (IMC) in ...
Effects of Cannabidiol, Hypothermia, and Their Combination in Newborn Rats with Hypoxic-Ischemic Encephalopathy
(Society for Neuroscience, 2023-04)
Therapeutic hypothermia is well established as a standard treatment for infants with hypoxic-ischemic (HI) encephalopathy but it is only partially effective. The potential for combination treatments to augment hypothermic ...
Ocoxin Increases the Antitumor Effect of BRAF Inhibition and Reduces Cancer Associated Fibroblast-Mediated Chemoresistance and Protumoral Activity in Metastatic Melanoma
(MDPI, 2021-02-21)
Whereas the prevalence of several cancer types is decreasing, skin malignancies are growing more common every year. Malignant melanoma is the most aggressive form of skin cancer with high metastatic capacity. In most cases, ...